Immune Function in Healthy Adolescents

Bartlett, Jacqueline A.; Schleifer, Steven J.; Demetrikopoulos, Melissa K.; Delaney, Beverly R.; Shiflett, Samuel C.; Keller, Steven E.

doi:10.1128/cdli.5.1.105-113.1998

Cited by 47 publications

(26 citation statements)

References 35 publications

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“…In agreement with other studies that evaluated the role of ageing in the lymphocyte phenotypes of apparently healthy subjects [26–29], our results showed a fall in the number of T cells expressing co‐stimulatory molecules CD28 + according to age in the group of H. pylori ‐negative adults. However, this correlation was lost in the group of H. pylori ‐positive patients, indicating that the infection leads to a persistent T‐cell activation.…”

Section: Discussionsupporting

confidence: 92%

Phenotypic Study of Peripheral Blood Lymphocytes and Humoral Immune Response in Helicobacter pylori Infection According to Age

Soares

Rocha

et al. 2005

Scand J Immunol

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Section: Discussionsupporting

confidence: 92%

Phenotypic Study of Peripheral Blood Lymphocytes and Humoral Immune Response in Helicobacter pylori Infection According to Age

Soares

Rocha

et al. 2005

Scand J Immunol

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“…It may be that NK cell sensitivity to catecholamines during exercise is greater in females given their greater lymphocyte ␤ 2 -adrenergic receptor density (50) and post-receptor activity (17,30) compared with men. From a functional perspective, NK cell cytotoxicity, as determined in whole blood, is less in women than in men (4,51), although this same difference was not confirmed in adolescents (3). It remains possible, however, that to compensate for relatively low NK cell cytotoxicity, females respond to physiological stress (i.e., acute exercise) with an overall greater influx of NK cells to the peripheral circulation, in particular the CD56 dim subset, which is the more cytotoxic population (11).…”

Section: Discussionmentioning

confidence: 94%

Sex-based effects on the distribution of NK cell subsets in response to exercise and carbohydrate intake in adolescents

Timmons

Tarnopolsky²,

Bar‐Or³

2006

Journal of Applied Physiology

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Carbohydrate (CHO) supplementation and female sex independently influence the natural killer (NK) cell response to acute exercise. Consequently, this study sought to elucidate sex-based differences in the distribution of NK cell subsets (i.e., CD56dim and CD56bright) in response to exercise and CHO intake. Twenty-two healthy 14-yr-old girls (n = 11) and boys (n = 11) cycled for 60 min at 70% maximal oxygen consumption while drinking 6% CHO (CT) or flavored water (WT). Blood was collected at rest, during exercise (30 and 60 min), and during recovery (30 and 60 min) to identify CD3- CD56dim and CD3- CD56bright NK cells. The activation marker CD69 was also determined on CD3- CD56+ cells. CD56dim responses, expressed as proportions or cell counts, were greater (P < or = 0.01) in girls by 67 and 105%, respectively. CD56bright cell counts (P = 0.006), but not CD56bright proportions (P = 0.89), were greater in girls by 82%. Both CD56dim and CD56bright subset responses, expressed as proportions or cell counts, were lower (P < or = 0.01) in CT vs. WT by 33-36%. The CD56bright-to-CD56dim ratio decreased at 30 min of exercise but increased during recovery (P < 0.001), with no effect of sex or CHO. Regardless of trial, CD3- CD56+ cells expressed approximately 18% higher levels of CD69 during recovery in girls but not boys (P = 0.03), despite similar proportions and counts of CD69+ cells. These results demonstrate sex-based differences in the distribution of NK cell subsets and activation status in response to exercise, but not CHO intake, and further support the need to control for sex in exercise immunology studies.

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“…As reported in other series from different countries (4-7), we have found a male predominance for this entity. It has been hypothesized that gender may confer a different risk to immune-related diseases (31). However, differences between both genders were not observed in an analysis of the gene expression profile in EE (32).…”

Section: Discussionmentioning

confidence: 95%

Eosinophilic esophagitis: an Italian experience

Vindigni

Villanacci

Marini

et al. 2010

Rev. esp. enferm. dig.

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Background: eosinophilic esophagitis is an esophageal disorder characterized by esophageal and/or upper gastrointestinal tract symptoms, and by dense esophageal eosinophilia associated with a normal gastric and duodenal mucosa. Prevalently reported in children, eosinophilic esophagitis has recently been reported with increased frequency also in adults. Aims: the purpose of this study was to report our experience with eosinophilic esophagitis in Italy, since there are only very few series of such patients in our country. Patients and methods: we retrospectively reviewed the histological data of consecutive patients with a diagnosis of esophagitis or reflux disease in the period September 2004-September 2008. Eosinophils were counted where they appeared most numerous in the biopsy, with a cutoff > 15 eosinophils in more than one high-power field as diagnostic of eosinophilic esophagitis. Patients were excluded if gastric or duodenal biopsies showed a prominent eosinophilic infiltrate. Results: twenty two patients (14 adults, 8 children, age range 2-59 years) were identified according to the above criteria. The average eosinophil count was 86/ high-power field (range 31-150), associated with other pathologic features (eosinophilic microabscesses eosinophil degranulation, basal zone hyperplasia, papillary elongation). The main clinical complaints were dysphagia, food impaction, and heartburn, and endoscopic findings consisted of mucosal thickening and inelasticity, longitudinal shearing, rings, and white specks, without difference between adults and children for both clinical and endoscopic variables. Conclusions: eosinophilic esophagitis is not rare in Italy, and displays clinical, endoscopic, and pathologic features similar to those described in other countries.

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Immune Function in Healthy Adolescents

Cited by 47 publications

References 35 publications

Phenotypic Study of Peripheral Blood Lymphocytes and Humoral Immune Response in Helicobacter pylori Infection According to Age

Phenotypic Study of Peripheral Blood Lymphocytes and Humoral Immune Response in Helicobacter pylori Infection According to Age

Sex-based effects on the distribution of NK cell subsets in response to exercise and carbohydrate intake in adolescents

Eosinophilic esophagitis: an Italian experience

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