Immune mechanisms leading to atopic dermatitis

Resolution of atopic dermatitis following allogeneic bone marrow transplantation for chronic myelogenous leukemia

“…7 Atopic dermatitis is thought to be an autoimmune or allergic disease, as indicated by increasing evidence for the role of a cellular immune reaction in the pathogenesis. 1,2 In the present case, the immunosuppressive treatment used to prevent GVHD may have also influenced the clinical course of the atopic dermatitis. However, it is unlikely that the long-lasting remission could be attributed to the tacrolimus given for 4 months after BMT, because recurrence of atopic dermatitis after discontinuation of tacrolimus is common.…”

“…1 A wide range of cellmediated immune defects associated with T-lymphocytes have been reported in atopic dermatitis. 2 Recently, some patients with coincidental autoimmune disease who underwent allogeneic bone marrow transplantation (BMT) for a malignancy have been cured of their autoimmune disease.…”

Atopic Dermatitis: an Update and Review of the Literature

“…A relative imbalance between Th1 and Th2 subsets of CD4+ T cells producing cytokines are indicative of prominent immune disorders in AD (22). AD is product of an interaction between various susceptibility genes, host and environmental factors, infectious agents, defects in skin barrier function and immunological responses (27). Activation of T lymphocytes, DCs, macrophages, keratinocytes, mast cells and eosinophiles are characteristic of AD skin inflammatory responses (10).…”

Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells

“…DNFB did not influence CD83 expression in peritoneal CD11b + cells from NC/Nga mice (Fig. 4F) (24). NC/Nga mice were developed as an AD model animal and originated from Japanese fancy mice at Nagoya University (Japan).…”