Immune‐mediated diseases: what can be found in the oral cavity?

Bascones-Martínez, A.; García-García, Virginia; Meurman, Jukka H.; Requena-Caballero, Luís

doi:10.1111/ijd.12681

Cited by 38 publications

(63 citation statements)

References 80 publications

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“…EM was previously thought to be part of the spectrum of SJS and TEN, but today it is recognized as a distinct entity with different clinical and epidemiological characteristics. 29,30 EM is manifested by characteristically raised, bullous skin lesions that are palpable. Epidermal detachment occurs in less than 10% of the body surface area and there is minimal mucous membrane involvement.…”

Section: Discussion Erythema Multiformementioning

confidence: 99%

See 1 more Smart Citation

Stevens-Johnson Syndrome without Skin Lesions: A Rare and Clinically Challenging Disease in the Urgent Setting

Anders¹,

Taylor²,

Kravchuk³

et al. 2015

Emerg Med Open J

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Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme are life threatening diseases causing mucocutaneous eruptions and can be difficult to manage medically. When oral tissues are involved, airway management can be of critical importance. Fluid and electrolyte imbalance are common and protocols to prevent secondary infection are initiated. All three conditions are rapidly evolving. Stevens-Johnson syndrome is more commonly associated with Mycoplasma pneumoniae in the pediatric population and drug hypersensitivity in adults, whereas erythema multiforme is mostly associated with herpes simplex virus in the adult population. These diseases are T-cell-mediated immune reactions, thought to represent a spectrum of the same disease. Clinical and immunohistochemical techniques are capable of differentiating Stevens-Johnson syndrome from erythema multiforme and provide insight into the possible underlying pathology creating the disease. Rare cases of Stevens-Johnson syndrome without skin manifestations have been associated with Mycoplasma pneumoniae and predominantly occur in males. In-hospital management is recommended to provide airway support, maintain fluid intake, electrolyte balance, obtain multi-speciality consultation, and to perform diagnostic testing. We describe a case of a 14 year old male with atypical Stevens-Johnson syndrome and a review of the literature.

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Section: Discussion Erythema Multiformementioning

confidence: 99%

“…Oral lesions are described as polymorphic, erosive, ampullary, and erythematosus. 29 EM occurs mostly in adults between 20 to 40 years old 31 and is most often caused by HSV.…”

Section: Discussion Erythema Multiformementioning

confidence: 99%

Stevens-Johnson Syndrome without Skin Lesions: A Rare and Clinically Challenging Disease in the Urgent Setting

Anders¹,

Taylor²,

Kravchuk³

et al. 2015

Emerg Med Open J

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“…Immune-mediated diseases frequently affected oral mucosa, which may be the first site of their clinical manifestation. Although etiology of these diseases still remains unknown, but recently have been found that some of them share common genes [45].…”

Section: Discussionmentioning

confidence: 99%

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

Čanković¹

2016

J. Dent. Sci. Ther

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Oral lichen planus (OLP) is a still poorly understood and relatively common chronic inflammatory disease of oral mucosa. A connection between OLP and certain diseases have been reported in the past, such as diabetes, hypertension, hepatitis C infection (HCV), thyroid disease, and malignant diseases. There is some controversial about mentioned link with OLP. The study objective was to investigate association between autoimmune diseases and OLP in Northern Serbian province. A total of 48 patients (33 females and 15 males, ranged 29-84 years, mean age 59.8 ± 13.0) with clinical and histopathological proven OLP, along with 71 matched controls without oral mucosa lesions were included in the study. This was a retrospective case-control study conducted in patients who were treated at the Dental Clinic, Faculty of Medicine, University of Novi Sad, between January 2010 and Jun 2016. Clinical characteristics of OLP lesions, other oral mucosal diseases, presence of cutaneous LP, medical and family history with special regard to their autoimmune diseases with medication intake were recorded. Association regarding total of autoimmune diseases was found significant especially in prevalence of thyroid gland diseases. This study indicates connection between thyroid gland disorders (Hashimoto thyroiditis) and OLP. There is a need for further investigations such a screening for asymptomatic OLP in woman over the 40 years old suffering from thyroid gland disorders, particularly hypothyroidism.

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“…A forma vulgar pode ter um prognósti-co grave, devido à possibilidade de seguir um curso clínico preocupante quando não diagnosticada e tratada inicialmente 3 . A patologia acomete com maior frequência indivíduos na idade adulta, entre a quinta e sexta décadas de vida, é particularmente rara em crianças e idosos, não foi observada nenhuma predileção por gênero, embora alguns estudos mostrem prevalência no gênero feminino 4 . A etiologia do pênfigo vulgar não é totalmente definida, mas pode ter a possibilidade da predisposição genética com forte associação dos alelos HLA (DRBI*0402 e DQBI*0503), além dos fatores endó-genos (alterações imunológicas), fatores exógenos (drogas, infecções, neoplasias e agentes físicos) e grupos raciais (judeus e descendentes da região mediterrânea) 5 .…”

Section: Introductionunclassified

Pênfigo vulgar na cavidade bucal: relato de caso clínico

Leite

Macedo

Simas

et al. 2016

Rev. da Fac. de Odontologia, UPF

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IntroduçãoAs doenças dermatológicas autoimunes são condições patológicas decorrentes da ativação do sistema imunológico contra elementos teciduais, particularmente da pele ou de superfícies das mucosas 1 . Dentre as dermatoses mais estudadas, podemos enfatizar o pênfigo, que é uma patologia imunologicamente mediada e caracterizada pela formação de bolhas intraepiteliais na pele e em mucosas 2 . O pênfigo vulgar é o tipo de pênfigo mais comum, mesmo assim ele não é observado com muita frequência. A forma vulgar pode ter um prognósti-co grave, devido à possibilidade de seguir um curso clínico preocupante quando não diagnosticada e tratada inicialmente 3 . A patologia acomete com maior frequência indivíduos na idade adulta, entre a quinta e sexta décadas de vida, é particularmente rara em crianças e idosos, não foi observada nenhuma predileção por gênero, embora alguns estudos mostrem prevalência no gênero feminino

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Immune‐mediated diseases: what can be found in the oral cavity?

Cited by 38 publications

References 80 publications

Stevens-Johnson Syndrome without Skin Lesions: A Rare and Clinically Challenging Disease in the Urgent Setting

Stevens-Johnson Syndrome without Skin Lesions: A Rare and Clinically Challenging Disease in the Urgent Setting

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

Pênfigo vulgar na cavidade bucal: relato de caso clínico

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