Immune microenvironment as a factor of breast cancer progression

Романюк, Анатолій Миколайович; Lуndіn, Mykola

doi:10.1186/s13000-015-0316-y

Cited by 25 publications

(20 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are also some studies showing that increased B-cell density is associated with higher recurrence frequencies in meningioma and prostate cancer, as well as with higher tumor grade and reduced OS in ovarian cancer or disease progression in breast cancer (16)(17)(18)(19). Single studies state no prognostic effect of TIL-Bs (20).…”

mentioning

confidence: 99%

High Density of Tumor-infiltrating B-Lymphocytes and Plasma Cells Signifies Prolonged Overall Survival in Adenocarcinoma of the Esophagogastric Junction

Knief

Reddemann

Petrova

et al. 2016

View full text Add to dashboard Cite

Abstract. Background: Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic significance in a variety of tumors. Not only T-cell, but also B-cell In recent years, studies concerning the microenvironment of tumors, especially tumor-infiltrating lymphocytes (TILs), have been abundant. This microenvironment has been shown to influence overall survival (OS), as well as relapse times, and probability of tumor recurrence (1, 2). However, most studies have focused on the relationship between T-cell infiltration and patients' outcome, while the role of tumor infiltrating B-lymphocytes (TIL-Bs), as well as plasma cells in this setting, is still poorly understood and less commonly investigated.Not only the presence, but also the distribution pattern has been described as being crucial to prognosis: In carcinomas, immune cells are predominantly found in the stroma (3) and the formation of dense, follicle-like lymphocyte infiltrates (so-called tertiary lymphatic structures (TLSs), which arise in non-lymphoid tissues, often in the context of chronic inflammation) has been reported to have the strongest impact on prognosis and survival (2, 4, 5).T-lymphocytes (especially cytotoxic T-cells), as well as Blymphocytes, increase and establish the activation of antitumoral immunity (as an adaptive mechanism), leading to increased cell death in tumors and resulting in improved prognosis in patients with high levels of TILs (2, 6). Tumorassociated plasma cells have been described to have a significant impact on prognosis through modulation of the humoral immune response (7).Up to date, most reports in the literature state a positive effect of TILs in respect to OS, relapse-free survival and association with favorable prognostic factors, as well as lower T-stage (8). High B-cell density is said to be associated with improved outcome in gastric, breast and colorectal cancer (9-11), as well as squamous cell carcinoma of the tongue (12), melanoma and hepatocellular carcinoma (5, 13). The same correlation has been shown for pancreatic adenocarcinomas, though here the impact was only measurable if cells were arranged in the pattern of TLSs (4,14). High proportions of TILs have also been shown to be predictive of response to neoadjuvant therapy in breast cancer patients (15). 5339

show abstract

mentioning

confidence: 99%

High Density of Tumor-infiltrating B-Lymphocytes and Plasma Cells Signifies Prolonged Overall Survival in Adenocarcinoma of the Esophagogastric Junction

Knief

Reddemann

Petrova

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The results of this project do indicate that a basic, high lymphocyte infiltration, without any other information regarding the characteristics of the lymphocytes other than their presences, as established by an H & E stain, is associated with a worse prognosis. There are many instances, and a large amount of data (Cai et al, ; Demaria et al, ; Dennis et al, ; Dulai, Sandborn, & Gupta, ; Fornaro et al, ; Grivennikov, Greten, & Karin, ; McLean et al, ; Pal et al, ; Romaniuk & Lуndіn, ; Viac, Bustamante, & Thivolet, ; Westbrook, Szakmary, & Schiestl, ), supporting the conclusion that inflammation is associated with cancer development, including in the case of endometrial carcinoma (Berstein, ; Trabert et al, ). However, given the association of a good prognosis with the above recovery of TRB recombination reads, as well as with other immune receptor recombination reads, the question becomes, which type of lymphocytes is associated with a poor prognosis?…”

Section: Discussionmentioning

confidence: 91%

TRB‐J1 usage, in combination with the HLA‐A*01:01 allele, represents an apparent survival advantage for uterine corpus endometrial carcinoma: Comparisons with microscopic assessments of lymphocyte infiltrates

Clark

Wei

Callahan

et al. 2018

Int J Immunogenetics

View full text Add to dashboard Cite

Summary The opportunity for the highly efficient recovery of immune receptor recombination data from cancer specimens, including the ready assessment of immune receptor V and J usage, raises the issue of establishing precise values of assessing the immune receptor status as opposed to obtaining basic information regarding lymphocyte infiltration, in the cancer setting. In this report, we obtained the lymphocyte infiltration percentages from the cancer digital slide archive representing uterine corpus endometrial carcinoma (UCEC) and correlated these data with recovery of the immune receptor recombination reads from corresponding UCEC exome files. Results indicated a basic correlation of the recovery of productive T‐cell receptor beta (TRB) recombination reads with lymphocyte infiltration percentages. However, the recovery of specific immune receptor recombination reads did not indicate the same survival outcomes as microscope detection of lymphocyte infiltrate percentages. To further exploit the value of recovery of the TRB recombination reads from the UCEC exome files, we determined the survival outcomes for combinations of TRB gene segment usage and HLA class I alleles, with the most important result being that the combination of HLA‐A*01:01 and TRB‐J1 segment usage reflected a strikingly high survival rate. Overall, this report emphasized the increased value of the knowledge of the immune receptor recombinations, in comparison with basic lymphocyte infiltration percentages, in assessing cancer survival rates.

show abstract

“…Various gene mutations arise in cells under the influence of diversified factors namely p53 gene mutation, which has expressed carcinogenic effect [18]. Perhaps this happened to woman's ancestors and was transmitted to her hereditarily.…”

Section: Discussionmentioning

confidence: 99%

Primary multiple tumor with affection of the thyroid gland, uterus, urinary bladder, mammary gland and other organs

Романюк

Lyndin

Smiyanov

et al. 2017

Pathology - Research and Practice

View full text Add to dashboard Cite

a b s t r a c tBackground: Nowadays multiple primary tumor is characterized by growth and development of two or more tumors in one patient. The total world sickness rate ranges from 1% to 37%. The presence of four or more tumors in one patient is rare case and presented as casuistry. Case presentation: We showed a case of multiple primary tumor with metahronic lesion of the thyroid, uterus and breast, followed by synchronous benign tumors of the subcutaneous fat, urinary bladder and gallbladder were considered. The development of all malignant tumors in all cases was accompanied by the presence of benign precancerous processes. Analysis of neoplasia histology shows the predominance of poorly differentiated forms of cancers in women with increased aggressiveness of cancerous tissue in each subsequent case and the growth of metastatic ability. The influence of heredity on the tumors progress is confirmed by immunohistochemical characteristics of cancer cells. Steroid-sensitive tissue of the uterus and breast in both cases didn't express ER and PR, in all cases the tissue had overexpression of Ki-67, p53, bax and bcl-2 receptors. The results of DNA testing for determination the Lynch syndrome revealed the presence of microsatellite instability in genetic material. The results of studies revealed the absence of mutations in these genes (MLH1, MSH2 and MSH6). Despite the negative results of the study, it doesn't exclude the possibility of Lynch syndrome for 100%, and its presence may be caused by the mutations of other genes (PMS1, PMS2 and MLH3), responsible for DNA repair. Unfortunately there wasn't any opportunity to study their mutations. Conclusions: While studying the anamnesis of life and disease of women it was revealed that she had multiple primary tumor with lesions of the breast, urinary bladder, thyroid, uterus and other organs. This study shows that neoplastic tissue in all cases had high rates of cell proliferation, their antiapoptotic stability, expression of prognostically unfavorable-receptors, and absence of favorable prognostic markers. Histological study revealed high rates of malignant neoplastic tissue. It indicates to the existence of common mechanisms of malignant tumors and their genetic predisposition that can be clearly observed in many generations of patient.

show abstract

Immune microenvironment as a factor of breast cancer progression

Cited by 25 publications

References 31 publications

High Density of Tumor-infiltrating B-Lymphocytes and Plasma Cells Signifies Prolonged Overall Survival in Adenocarcinoma of the Esophagogastric Junction

High Density of Tumor-infiltrating B-Lymphocytes and Plasma Cells Signifies Prolonged Overall Survival in Adenocarcinoma of the Esophagogastric Junction

TRB‐J1 usage, in combination with the HLA‐A*01:01 allele, represents an apparent survival advantage for uterine corpus endometrial carcinoma: Comparisons with microscopic assessments of lymphocyte infiltrates

Primary multiple tumor with affection of the thyroid gland, uterus, urinary bladder, mammary gland and other organs

Contact Info

Product

Resources

About