Immune‐modified Glasgow prognostic score: A new prognostic marker for head and neck cancer

Terazawa, Kosuke; Ohashi, Toshimitsu; Shibata, Hirofumi; Ishihara, Takuma; Ogawa, Takenori

doi:10.1002/hed.27170

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…Terazawa et al studied head and neck cancer patients and found a significant relationship between survival, low albumin, and high CRP. However, mGPS failed to predict poor prognosis in this patient group [10]. Siyu et al reported that GPS and mGPS could act as poor prognostic indicators in patients with ovarian cancer [11].…”

Section: Discussionmentioning

confidence: 74%

“…Like CAR, GPS and mGPS have been assessed as inflammation markers, especially in patients with malignancies [10][11][12]. Terazawa et al studied head and neck cancer patients and found a significant relationship between survival, low albumin, and high CRP.…”

Section: Discussionmentioning

confidence: 99%

“…CAR has been studied in patients with malignancies [4,5], Crohn's disease [6], sepsis [7], pneumonia [8], and coronavirus disease 2019 (COVID-19) [9]. In addition, recent studies on patients with inflammatory diseases [10][11][12] and acute cholecystitis [13][14][15] suggest that the CAR, Glasgow prognostic score (GPS), and modified GPS (mGPS) are effective in evaluating acute cholecystitis prognosis in patients. It has also been reported that GPS and mGPS are effective in predicting prognosis in colorectal cancers [16,17].…”

Section: Introductionmentioning

confidence: 99%

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The Role of C-Reactive Protein and Albumin Combined Indexes in Acute Cholecystitis

Akça

GÜRLEVİK²,

AKÇA

et al. 2022

International Journal of Health Services Research and Policy

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Aim This study aimed to determine and compare the abilities of the CAR, GPS, and mGPS to predict short-term mortality in patients with acute cholecystitis. Materials and Methods This retrospective study used the examinations and data of patients who attended the Emergency Department were used. The Statistical Package for Social Sciences (SPSS) software (v.20; Chicago, IL, USA) was used for all statistical analyses. All results with p < 0.05 were considered statistically significant. Results This study included 269 patients aged 58.3±17.4 years, of which 51% were women. The abilities of CAR, GPS, and mGPS to predict mortality were found to be statistically significant. Their AUC values were 0.73 (0.09–0.98) for CAR with a cut-off value of 3.9 (p = 0.003), 0.72 (0.10–0.97) for GPS with a cut-off value of 2 (p = 0.006), and 0.73 (0.10–0.97) for mGPS with a cut-off value of 2. Conclusions Inflammatory markers, including CRP and albumin, can predict the prognosis of patients with acute cholecystitis, as in many other diseases.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of C-Reactive Protein and Albumin Combined Indexes in Acute Cholecystitis

Akça

GÜRLEVİK²,

AKÇA

et al. 2022

International Journal of Health Services Research and Policy

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“…The study demonstrated that imGPS offers better accuracy than mGPS in predicting the evolution of patients with HNSCC. mGPS is considered a precise predictor of OS for patients with HNC and after analyzing the data of the study carried out at the University of Tsukuba Hospital including 210 cases of HNC, values of 1 and 2 of the score are associated with worst outcomes (23).…”

Section: Discussionmentioning

confidence: 99%

Implications of diabetes in head and neck cancer – A single center real-world data

Mireștean¹,

Stan²,

Bădulescu³

2023

BLL

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Diabetes mellitus (DM) and altered glucose metabolism have been associated with carcinogenesis, but also with prognosis and tolerance to treatment in different types of cancer. Head and neck cancers (HNC), the sixth most common malignancy worldwide, require a multimodal approach, especially in advanced stages and cancer specifi c treatment is often associated with therapeutic failure and severe toxicities even if it is delivered according to current standards. The aim of the study was to evaluate the clinical, biological and outcomes implications of DM in patients with HNC. The cases diagnosed with HNC associated with DM between January 2008 and December 2016 were selected from the database of the oncology clinic and the oncology outpatient clinic of the Craiova County Hospital. Under the limits of a relatively reduced patient lot of 23 cases, certain particular aspects of these cases are highlighted possibly due to the association of DM with HNC. This category of patients should not be treated differently even if a precaution is necessary due to the increased risk of complications related to treatment. The use of Metformin could bring outcome benefi t and the treatment of DM with insulin could be associated with a worst prognostic. The use of poly-chemotherapy regimens (platinum double or triple combination including platinum salts) demonstrates the feasibility of using chemotherapy for these subtypes of patients. A tendency to de-escalate the treatment by omitting radiotherapy for this category of patients should also be noted. Neutrophil to lymphocyte ratio (NLR), a less specifi c biomarker could be less useful than the Glasgow Prognostic Score (GPS) which can be considered an accessible biomarker. A large percent of sinonasal cancers compared to the data reported in the literature could be also related to DM. Both this possible association and the benefi t of Metformin and 5-Flurouracil must be reevaluated in studies in larger groups of patients (Ref. 25).

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“…a useful prognostic tool for malignant tumors. [6,7] The mGPS correlates with clinical outcomes in patients with head and neck cancers [27]. High CAR predicts early recurrence and poor prognosis in patients with gastric cancer with curative intent.…”

mentioning

confidence: 99%

CT-assessed sarcopenia and prognostic nutritional index are associated with poor prognosis in oral squamous cell carcinoma

Ohyama,

Inaba,

Kubota

et al. 2023

Oral Maxillofac Surg

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Recently, it has been reported that sarcopenia and nutritional evaluation are associated with the prognosis of patients with cancer; however, there are only a few detailed reports on oral cancer. This single center retrospective study aimed to analyze the relationship between computed tomography (CT)de ned sarcopenia, immunocompetence, nutritional status, and the prognosis of patients with oral squamous cell carcinoma (OSCC). MethodsWe included 146 patients who underwent initial radical surgery as rst-line treatment for OSCC. Skeletal muscle in the third cervical vertebra (C3) was measured using preoperative cervical CT, and the skeletal muscle index (SMI) was calculated. Sarcopenia and nutritional status were investigated using blood tests. The correlation between each parameter and prognosis was analyzed. Survival rates were calculated using the Kaplan-Meier method. Log-rank and chi-square tests were used to compare survival rates between groups, and multivariate analysis was performed using the Cox proportional hazards model. ResultsPatients included 67 men and 79 women, from 20 to 94 years. The number of patients with sarcopenia de ned using preoperative CT (CT-SP) was 76 (52%). In univariate analysis, CT-SP, prognostic nutritional index (PNI), and lymphocyte-monocyte ratio (LMR) were associated with poor prognosis, with statistically signi cant differences in disease-speci c survival (DSS) and overall survival. In multivariate analysis, only CT-SP was identi ed as an independent prognostic factor for DSS. A statistically signi cant correlation between CT-SP and PNI was found. ConclusionCT-SP is associated with a signi cant decrease in survival rate in patients with OSCC. Furthermore, CT-SP is correlated with PNI.

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Immune‐modified Glasgow prognostic score: A new prognostic marker for head and neck cancer

Cited by 8 publications

References 33 publications

The Role of C-Reactive Protein and Albumin Combined Indexes in Acute Cholecystitis

The Role of C-Reactive Protein and Albumin Combined Indexes in Acute Cholecystitis

Implications of diabetes in head and neck cancer – A single center real-world data

CT-assessed sarcopenia and prognostic nutritional index are associated with poor prognosis in oral squamous cell carcinoma

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