Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation

Chang, Ying‐Jun; Zhao, Xiaosu; Huang, Xiao‐Jun

doi:10.1016/j.bbmt.2013.11.028

Cited by 89 publications

(82 citation statements)

References 108 publications

(201 reference statements)

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“…36 Ciurea et al 37 compared TCR and TCD haploidentical HSCT and found that TCR protocol had a fast immune recovery. This result is in accordance with our data, 7,38 suggesting that a rapid immune reconstitution may contribute to a superior outcome as reported by Ciurea et al 37 Interestingly, healthrelated quality of life in unmanipulated HBMT at our centre is comparable to that in patients receiving HLA-identical sibling allo-HSCT. 39 Furthermore, other factors such as donor age can also be a useful predictive factor.…”

Section: Discussionsupporting

confidence: 93%

EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation

et al. 2014

Bone Marrow Transplant

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Systematic, standardised pretransplant risk assessment is an important tool for predicting patient outcomes following allogeneic haematopoietic SCT (HSCT). To assess the European Group for Blood and Marrow Transplantation (EBMT) risk score capacities for predicting patient outcomes following unmanipulated haploidentical blood and marrow transplantation (HBMT), we analysed 502 leukaemia patients who received transplants at our centre between 2008 and 2010. The cohort OS and leukaemia-free survival (LFS) were 72.1% and 68.1%, whereas the cumulative non-relapse mortality (NRM) and relapse incidences were 16.5% and 16.1%. According to univariate analysis, the values for OS, LFS and NRM were worse for an EBMT risk score of 6 (40.0, 40.0, 50.0%) than a score of 1 (83.1, 78.3, 8.4%). Hazard ratios steadily increased for each additional score point. Likewise, a higher EBMT risk score was associated with an increased relapse incidence. Importantly, the EBMT risk score prognostic value regarding OS, LFS, NRM and relapse was maintained in the multivariate analysis. Moreover, we also made a haploidentical EBMT (haplo-EBMT) risk score, which used number of HLA disparity instead of donor type, and the haplo-EBMT risk scores can also be used to predict patient outcomes following unmanipulated HBMT.

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Section: Discussionsupporting

confidence: 93%

EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation

et al. 2014

Bone Marrow Transplant

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“…B-cell recovery was superimposable in TBI and TLI patients. In contrast with what was observed for T-cell subsets, na€ ve B-cell counts recovered before memory B cells as previously reported by other groups of investigators (7,(45)(46)(47), including after HLA-haploidentical stem cell transplantation (48). Specifically, median na€ ve B-cell counts were already within the normal ranges 180 days after transplantation while unswitched memory B cells remained below normal ranges the first year after transplantation in both arms, and switched B cells reached the lower limit of normal values 2 years after transplantation.…”

Section: C-h Recovery Of Cd8supporting

confidence: 78%

Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning

Hannon

Béguin

Ehx

et al. 2015

Clinical Cancer Research

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Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been developed to induce graft-versus-tumor effects without graft-versus-host disease (GVHD).Experimental Design: We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n ¼ 28) or 8 Gy TLI plus ATG (TLI arm, n ¼ 25).Results: In comparison with TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P ¼ 0.02), a higher incidence of CMV reactivation (P < 0.001), and a higher incidence of relapse (P ¼ 0.01). While recovery of total CD8þ T cells was similar in the two groups, with median CD8 þ Tcell counts reaching the normal values 40 to 60 days after allo-HCT, TLI patients had lower percentages of na€ ve CD8 T cells. Median CD4 þ T-cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Furthermore, CD4 þ T-cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, while median absolute regulatory T-cell (Treg) counts were comparable in TBI and TLI patients, Treg/na€ ve CD4 þ T-cell ratios were significantly higher in TLI than in TBI patients the 2 first years after transplantation. Conclusions: Immune recovery differs substantially between these two conditioning regimens, possibly explaining the different clinical outcomes observed (NCT00603954).

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“…Considering the effects of recovered immune cells on transplant outcomes reported by others 29 and us, 30,31 our results provide a reasonable explanation for the similarities in clinical outcomes after NIMA-mismatched and NIPA-mismatched unmanipulated HBMT.…”

Section: Cd25supporting

confidence: 82%

Lower incidence of acute GVHD is associated with the rapid recovery of CD4⁺CD25⁺CD45RA⁺ regulatory T cells in patients who received haploidentical allografts from NIMA-mismatched donors: A retrospective (development) and prospective (validation) cohort-based study

Wang

Zhao

et al. 2016

OncoImmunology

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To investigate the effects of non-inherited maternal antigen (NIMA) on clinical outcomes and immune recovery, especially of regulatory T cells (Tregs), in patients who underwent unmanipulated haploidentical transplantation. A retrospective cohort (n D 57) and a prospective cohort (n D 88) were included. All patients received haploidentical allografts from sibling donors. Reconstitution of immune subsets, including Tregs, was determined using multicolor flow cytometry. In the retrospective cohort, the cumulative incidence of grades II-IV acute GVHD in patients with NIMA-mismatched donors was significantly lower than that of cases with NIPA-mismatched donors (14.8% vs. 43.30%, p D 0.018). Patients with higher percentages of CD4 C CD25 C CD45RA C T cells (naive Tregs) within CD4 C T cells recovered on day 30 (1.55%) experienced a significantly lower incidence of grades II-IV acute GVHD than that of cases with lower percentages of naive Tregs (<1.55%) (13.

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Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation

Cited by 89 publications

References 108 publications

EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation

EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation

Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning

Lower incidence of acute GVHD is associated with the rapid recovery of CD4⁺CD25⁺CD45RA⁺ regulatory T cells in patients who received haploidentical allografts from NIMA-mismatched donors: A retrospective (development) and prospective (validation) cohort-based study

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Immune Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation

Cited by 89 publications

References 108 publications

EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation

EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation

Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning

Lower incidence of acute GVHD is associated with the rapid recovery of CD4+CD25+CD45RA+ regulatory T cells in patients who received haploidentical allografts from NIMA-mismatched donors: A retrospective (development) and prospective (validation) cohort-based study

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Lower incidence of acute GVHD is associated with the rapid recovery of CD4⁺CD25⁺CD45RA⁺ regulatory T cells in patients who received haploidentical allografts from NIMA-mismatched donors: A retrospective (development) and prospective (validation) cohort-based study