Immune reconstitution inflammatory syndrome following allo-SCT in a patient with Dipodascus capitatus spondylodiscitis

Lapusan, Simona; Dimicoli, Sophie; Marjanovic, Zora; Lefebvre, Aline; Bordonné, Corinne; Lacroix, Claire; Me, Bougnoux; B, Rio; Lortholary, Olivier; Cornet, Muriel

doi:10.1038/bmt.2010.267

Cited by 7 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the haemato‐oncology setting, 60–80% of patients present with deep organ involvement . Indeed, it has been recognized as a cause of skin lesions similar to those observed during disseminated candidiasis, hepatosplenic abscesses , pancreatic infections , brain abscesses , funguria , acute renal failure due to fungal occlusion of glomeruli and osteomyelitis, mostly with vertebral involvement . Central venous catheters have been recognized as a potential portal of entry .…”

Section: Saprochaetementioning

confidence: 99%

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections

Arendrup

Boekhout

Akova

et al. 2014

Clinical Microbiology and Infection

432

396

View full text Add to dashboard Cite

The mortality associated with invasive fungal infections remains high with that involving rare yeast pathogens other than Candida being no exception. This is in part due to the severe underlying conditions typically predisposing patients to these healthcare-related infections (most often severe neutropenia in patients with haematological malignancies), and in part due to the often challenging intrinsic susceptibility pattern of the pathogens that potentially leads to delayed appropriate antifungal treatment. A panel of experts of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) and the European Confederation of Medical Mycology (ECMM) undertook a data review and compiled guidelines for the diagnostic tests and procedures for detection and management of rare invasive yeast infections. The rare yeast pathogens were defined and limited to the following genera/species: Cryptococcus adeliensis, Cryptococcus albidus, Cryptococcus curvatus, Cryptococcus flavescens, Cryptococcus laurentii and Cryptococcus uniguttulatus (often published under the name Filobasidium uniguttulatum), Malassezia furfur, Malassezia globosa, Malassezia pachydermatis and Malassezia restricta, Pseudozyma spp., Rhodotorula glutinis, Rhodotorula minuta and Rhodotorula mucilaginosa, Sporobolomyces spp., Trichosporon asahii, Trichosporon asteroides, Trichosporon dermatis, Trichosporon inkin, Trichosporon jirovecii, Trichosporon loubieri, Trichosporon mucoides and Trichosporon mycotoxinivorans and ascomycetous ones: Geotrichum candidum, Kodamaea ohmeri, Saccharomyces cerevisiae (incl. S. boulardii) and Saprochaete capitatae (Magnusiomyces (Blastoschizomyces) capitatus formerly named Trichosporon capitatum or Geotrichum (Dipodascus) capitatum) and Saprochaete clavata. Recommendations about the microbiological investigation and detection of invasive infection were made and current knowledge on the most appropriate antifungal and supportive treatment was reviewed. In addition, remarks about antifungal susceptibility testing were made.

show abstract

Section: Saprochaetementioning

confidence: 99%

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections

Arendrup

Boekhout

Akova

et al. 2014

Clinical Microbiology and Infection

432

396

View full text Add to dashboard Cite

show abstract

“…Tos, expectoración, dolor torácico, neumotórax espontáneo e infiltrados pulmonares son hallazgos reportados 14 . Otras manifestaciones incluyen infecciones pancreáticas; compromiso del SNC que cirugía en el manejo de la infección por Saprochaete capitata -J. Radich et al puede presentarse en forma de una lesión localizada (absceso), meningitis o encefalitis; funguria y falla renal aguda; osteomielitis y espondilodiscitis; y endocarditis 7,5,[16][17][18][19][20][21] . La infección diseminada y multifocal es la forma de presentación más observada.…”

Section: Discussionunclassified

Rol de la cirugía en el manejo de la infección invasora por Saprochaete capitata

et al. 2017

View full text Add to dashboard Cite

show abstract

“…S.capitata'ya bağlı osteoartiküler enfeksiyonlar genellikle vertebra tutulumu ile kendini göstermektedir 2 . Bu patojenin etken olduğu ve paravertebral apsenin de eşlik edebildiği spondilodiskit olguları bildirilmiştir 4,7,9,16,17 . Yoshihara ve arkadaşları, 14 yaşındaki akut lenfoblastik lösemili erkek hastada itrakonazol profilaksisine rağmen kostal kartilajlar ve lumbar vertebralarda çoklu lezyonlar izlenmesi üzerine alınan biyopsi örneğinde S.capitata üremesi tespit edildiğini ve amfoterisin B ve flukonazol ile tedavi başarısı sağlandığını bildirmiştir 16 .…”

Section: Resim 1 (A) Saprochaete Capitata'nın Kuru Buruşuk Maya Benunclassified

Fungemia and Septic Arthritis Caused by Saprochaete capitata in a Patient with Fanconi Aplastic Anemia: A Case Report

Parkan

Atalay²,

Koç³

et al. 2017

Mikrobiyol Bul

View full text Add to dashboard Cite

Saprochaete capitata (formerly known as Blastoschizomyces capitatus, Trichosporon capitatum, Geotrichum capitatum) is a rare but emerging yeast-like fungus. It is commonly found in environmental sources and can be isolated from skin, gastrointestinal system and respiratory tract of healthy individuals as well. It mainly infects patients with hematological malignancies such as acute myeloid leukemia (AML), especially in the presence of neutropenia; and mortality rates are high in those patients. Although the data about the in vitro antifungal susceptibility are limited, it is being reported that amphotericin B and voriconazole are more effective on S.capitata isolates whereas caspofungin had no activity. Here, we report a case of fungemia and septic arthritis due to S.capitata in a patient with Fanconi aplastic anemia. A 22-year-old male patient with Fanconi aplastic anemia was hospitalized in our hematology department for bone marrow transplantation. Two days after the hospitalization, neutropenic fever developed and multiple nodules similar to candidiasis were detected in his liver with the whole abdomen magnetic resonance imaging (MRI). Caspofungin treatment (single 70 mg/kg loading dose, followed by 1 x 50 mg/kg/day) was started. The patient remained febrile, and his blood culture yielded S.capitata. The treatment regimen was changed to a combination of liposomal amphotericin B (3 mg/kg/day) and voriconazole (2 x 4 mg/kg/day). A few days later, pain and swelling came out on patient's left knee and he underwent a surgical process with the prediagnosis of septic arthritis. Culture of synovial fluid was also positive for S.capitata. On the 26th day of the hospitalization, the patient died due to sepsis and multiple organ failure. Patient's blood and synovial fluid samples were incubated in BacT/Alert automated blood culture system (bioMérieux, France). After receiving the growth signal, yeast cells were seen in Gram staining and cream-coloured, wrinkled, yeast-like colonies that were able to grow at 45oC and resistant to cycloheximide were detected on Sabouraud dextrose agar (SDA). Urease test was negative, and according to API 20C AUX (bioMérieux, France) system, none of the carbonhydrates were utilized except glucose. The isolates that were able to produce annelloconidia in corn meal-Tween 80 agar slide culture were identified as S.capitata. The identification was further confirmed by DNA sequence analysis. Minimal inhibitory concentrations (MICs) of amphotericin B, fluconazole, voriconazole, and caspofungin were found to be 0.5 µg/ml, 1.5 µg/ml, 0.032 µg/ml, and > 16 µg/ml respectively. Repetitive sequence based PCR (rep-PCR) (DiversiLab system, bioMérieux, France) was used to determine clonal relatedness of the isolates from blood and synovial fluid samples. The isolates were indistinguishable (similarity coefficient > 97%) according to rep-PCR. In conclusion, S.capitata infections should be taken into consideration in the presence of fungemia and septic arthritis in hematological patients who receive caspofu...

show abstract

Immune reconstitution inflammatory syndrome following allo-SCT in a patient with Dipodascus capitatus spondylodiscitis

Cited by 7 publications

References 8 publications

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections

ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections

Rol de la cirugía en el manejo de la infección invasora por Saprochaete capitata

Fungemia and Septic Arthritis Caused by Saprochaete capitata in a Patient with Fanconi Aplastic Anemia: A Case Report

Contact Info

Product

Resources

About