Immune reconstitution inflammatory syndrome of tuberculosis among HIV-infected patients receiving antituberculous and antiretroviral therapy

Manosuthi, Weerawat; Kiertiburanakul, Sasisopin; Phoorisri, Thanongsri; Sungkanuparph, Somnuek

doi:10.1016/j.jinf.2006.01.002

Cited by 115 publications

(96 citation statements)

References 24 publications

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“…Having extrapulmonary or disseminated TB as a risk factor for TB-IRIS has been reported in the medical literature. 24,[26][27][28] This may be explained by a greater mycobacterial burden present in those with extrapulmonary or disseminated TB and a greater immunologic response to the dead or dying mycobacteria with ART during TB-IRIS.…”

mentioning

confidence: 99%

Immunologic Markers as Predictors of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in HIV and Tuberculosis Coinfected Persons in Thailand

Tieu

Ananworanich

Avihingsanon

et al. 2009

AIDS Research and Human Retroviruses

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This study analyzes immunologic markers to predict and diagnose tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in HIV and TB coinfected adults who initiated antiretroviral therapy (ART) in Thailand. T helper 1 cytokines interleukin (IL)-2, IL-12, and interferon-gamma (IFN-g) levels in response to PPD and RD1 antigens were assessed prior to ART, at weeks 6, 12, and 24 of treatment, and at time of TB-IRIS. Of 126 subjects, 22 (17.5%) developed TB-IRIS; 14 (64%) subjects received steroid treatment and 3 (14%) received NSAIDs; none of the subjects died. Median interval between ART initiation and TB-IRIS development was 14 days. IFN-g, IL-2, and IL-12 responses did not differ between TB-IRIS and no TB-IRIS subjects ( p > 0.05). More research into the immunopathogenesis of TB-IRIS and diagnostic potential of cytokine markers is warranted.

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mentioning

confidence: 99%

Immunologic Markers as Predictors of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in HIV and Tuberculosis Coinfected Persons in Thailand

Tieu

Ananworanich

Avihingsanon

et al. 2009

AIDS Research and Human Retroviruses

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show abstract

“…36 Patients with HIV and tuberculosis being treated with HAART should be carefully observed with respect to sequencing of treatment, the value of directly observed therapy, and the possibility of pharmacokinetic drug interactions that could result in toxicities, particularly hepatotoxicity and neuropathy. 37,38 Despite effective drug therapy, surgery in the form of ablation (e.g. nephrectomy) or reconstruction (e.g.…”

Section: Tuberculosismentioning

confidence: 99%

Urologic complications of HIV and AIDS

2009

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“…Interestingly, extrapulmonary TB is a prominent risk factor for IRIS. (Manosuthi et al, 2006) E. The stage between LTBI and active TB infection. It features opacities in the lungs, but sputum and IGRAs test are negative.…”

Section: Network Among Ltbi and Hivmentioning

confidence: 99%