Immune Regulation of Human Embryo Implantation by Circulating Blood Cells

Fujiwara, Hiroshi; Sato, Yukiyasu; Ideta, Atsushi; Aoyagi, Yoshito; Araki, Yoshihiko; Imakawa, Kazuhiko

doi:10.5772/32365

Cited by 2 publications

(3 citation statements)

References 41 publications

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“…Several mechanisms relevant to this procedure can be proposed as follows . Firstly, PBMC may induce endometrial differentiation that facilitates embryo attachment.…”

Section: Clinical Approach To Infertile Patients Applying Positive Immentioning

confidence: 99%

Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems – Step‐by‐Step Maternal Recognition of the Developing Embryo

Fujiwara

Araki

Imakawa

et al. 2016

American J Rep Immunol

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In humans, HCG secreted from the implanting embryo stimulates progesterone production of the corpus luteum to maintain embryo implantation. Along with this endocrine system, current evidence suggests that the maternal immune system positively contributes to the embryo implantation. In mice, immune cells that have been sensitized with seminal fluid and then the developing embryo induce endometrial differentiation and promote embryo implantation. After hatching, HCG activates regulatory T and B cells through LH/HCG receptors and then stimulates uterine NK cells and monocytes through sugar chain receptors, to promote and maintain pregnancy. In accordance with the above, the intrauterine administration of HCG-treated PBMC was demonstrated to improve implantation rates in women with repeated implantation failures. These findings suggest that the maternal immune system undergoes functional changes by recognizing the developing embryos in a stepwise manner even from a pre-fertilization stage and facilitates embryo implantation in cooperation with the endocrine system.

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“…Several mechanisms relevant to this procedure can be proposed as follows . Firstly, PBMC may induce endometrial differentiation that facilitates embryo attachment.…”

Section: Clinical Approach To Infertile Patients Applying Positive Immentioning

confidence: 99%

Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems – Step‐by‐Step Maternal Recognition of the Developing Embryo

Fujiwara

Araki

Imakawa

et al. 2016

American J Rep Immunol

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“…A large number of published studies have strongly suggested that various physiological changes in the immune‐ (and/or unknown‐) systems occur systemically in pregnant women (for review, see Fujiwara et al . 2012) . This presumably occurs under specific homeostasis conditions within biological ‘fluctuation’, including dynamic equilibrium between proteases and their inhibitors.…”

Section: Potential Utility Of the One‐step Direct Transfer Technologymentioning

confidence: 99%

“…A large number of published studies have strongly suggested that various physiological changes in the immune-(and/or unknown-) systems occur systemically in pregnant women (for review, see Fujiwara et al 2012). 53 This presumably occurs under specific homeostasis conditions within biological 'fluctuation', including dynamic equilibrium between proteases and their inhibitors. Therefore, comprehensive peptidomic analyses likely reflect the physiological/pathophysiological status of pregnant women, and this approach will lead to a new clinical direction for obstetricians in general.…”

Section: Potential Utility Of the One-step Direct Transfer Technologymentioning

confidence: 99%

Clinical peptidomic analysis by a one‐step direct transfer technology: Its potential utility for monitoring of pathophysiological status in female reproductive system disorders

Araki

Nonaka²,

Hamamura

et al. 2013

J of Obstet and Gynaecol

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To date, numerous studies have searched for candidate molecules or clinical examination methods as potential biomarkers for monitoring intractable diseases, such as carcinomas. Evidence accumulated over the past decade shows that many proteolytic peptides appear in human humoral fluids, including peripheral blood, in association with an individual's health condition. Although an analysis of the whole peptide (the 'peptidome') using mass spectrometry is thought to be one of the most powerful and promising experimental approaches, it has failed to identify biomarkers in the clinical blood samples, presumably due to the methodological limitations. In general, commonly used techniques for proteomic analysis of blood require the removal of large amounts of serum/plasma proteins prior to mass spectrometry analysis, and this step seems to have resulted in the overlooking of important biomarkers during the analytical process. Here, we provide a brief overview of a new quantitative peptidomic analysis by a one-step direct transfer technology without depletion of major blood proteins. Using this technology, we herein report experimental data on serum peptidomic analysis for patients with pregnancy-induced hypertension as a clinical model. In addition, we refer to the potential utility of this approach for the monitoring of pathophysiological status in female reproductive system disorders in general.

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Immune Regulation of Human Embryo Implantation by Circulating Blood Cells

Cited by 2 publications

References 41 publications

Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems – Step‐by‐Step Maternal Recognition of the Developing Embryo

Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems – Step‐by‐Step Maternal Recognition of the Developing Embryo

Clinical peptidomic analysis by a one‐step direct transfer technology: Its potential utility for monitoring of pathophysiological status in female reproductive system disorders

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