Immune response‐mediated pathology in human intestinal parasitic infection

Farthing, M. J. G.

doi:10.1046/j.1365-3024.2003.00633.x

Cited by 23 publications

(12 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Symptoms of giardiasis include malabsorptive diarrhea, cramps, and nausea and are similar to those noted in food allergies, celiac disease, and other intestinal disorders. In several of these diseases and in several animal models, mast cells have been implicated in contributing to this pathology (Farthing, 2003). Additionally, the reported increase in serum MCP-1 and histamine levels observed after infection of C57BL/6 mice suggest that symptoms of giardiasis may be related to allergic processes (Di Prisco et al , 1998).…”

Section: Discussionmentioning

confidence: 99%

Histamine and TNF-α release by rat peritoneal mast cells stimulated withTrichomonas vaginalis

Ahn

Han

et al. 2011

Parasite

View full text Add to dashboard Cite

Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-α and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-α. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.

show abstract

Section: Discussionmentioning

confidence: 99%

Histamine and TNF-α release by rat peritoneal mast cells stimulated withTrichomonas vaginalis

Ahn

Han

et al. 2011

Parasite

View full text Add to dashboard Cite

show abstract

“…Serum IgE is a polyclonal response that has been associated with antigen-specific and nonspecific immune stimulation (36). In developed countries, elevated IgE is most commonly associated with allergies (37), and in developing tropical areas, such as Tumaco, elevated IgE is most commonly associated with parasitism (23).…”

Section: Discussionmentioning

confidence: 99%

Intestinal Helminthiasis in Colombian Children Promotes a Th2 Response to Helicobacter pylori: Possible Implications for Gastric Carcinogenesis

Whary

Sundina

Bravo

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Colombians living in coastal Tumaco have a lower incidence of Helicobacter pylori -associated gastric cancer compared with residents of Pasto in the high Andes. Considering the risk for H. pylori disease seems affected by features of bacterial virulence and host polymorphisms, other poorly understood influences, such as concurrent helminthiasis, may also be important. Methods: Fecal samples from 211 children were tested for parasites and sera from another cohort of 159 children and 92 adults were tested for IgE and H. pylori -specific IgG. Results: Most individuals (95%) from both areas were H. pylori seropositive, with a predominant response of IgG1 followed by IgG2 and low IgG3 and IgG4 antibodies. Compared with Pasto children, Tumaco children were more

show abstract

“…Intestinal anaphylaxis, with IgE-induced mast cells degranulation, is responsible for changes in the intestine physiology as well as architecture and chemistry of the gut epithelium, including stimulation of fluid, electrolyte and mucus secretion, smooth muscle contractility, increased vascular and epithelial permeability, and recruitment of immune cells such as eosinophil or mast cells [24] (Figure 3). This can lead to rapid elimination of the gastrointestinal larvae, before they reach their tissue niche, and to expulsion of the adult [25].…”

Section: Effector Immune Mechanisms Against Helminths and Their Rementioning

confidence: 99%

Immunity against Helminths: Interactions with the Host and the Intercurrent Infections

Moreau¹,

Chauvin²

2010

Journal of Biomedicine and Biotechnology

163

136

View full text Add to dashboard Cite

Helminth parasites are of considerable medical and economic importance. Studies of the immune response against helminths are of great interest in understanding interactions between the host immune system and parasites. Effector immune mechanisms against tissue-dwelling helminths and helminths localized in the lumen of organs, and their regulation, are reviewed. Helminth infections are characterized by an association of Th2-like and Treg responses. Worms are able to persist in the host and are mainly responsible for chronic infection despite a strong immune response developed by the parasitized host. Two types of protection against the parasite, namely, premune and partial immunities, have been described. Immune responses against helminths can also participate in pathogenesis. Th2/Treg-like immunomodulation allows the survival of both host and parasite by controlling immunopathologic disorders and parasite persistence. Consequences of the modified Th2-like responses on co-infection, vaccination, and inflammatory diseases are discussed.

show abstract

Immune response‐mediated pathology in human intestinal parasitic infection

Cited by 23 publications

References 95 publications

Histamine and TNF-α release by rat peritoneal mast cells stimulated withTrichomonas vaginalis

Histamine and TNF-α release by rat peritoneal mast cells stimulated withTrichomonas vaginalis

Intestinal Helminthiasis in Colombian Children Promotes a Th2 Response to Helicobacter pylori: Possible Implications for Gastric Carcinogenesis

Immunity against Helminths: Interactions with the Host and the Intercurrent Infections

Contact Info

Product

Resources

About