Immune Response on Mice Infected with Schistosoma mansoni and Treated with Myrrh

The potent effect of silymarin combination with Praziquantel or mirazid for Schistosoma mansoni treatment in infected male swiss albino mice

“…While, the infected groups treated with MZ alone or combined with silymarin also showed decreasing of IgG detection compared to untreated infected group, but more than infected groups treated with PZQ. These findings were the opposite of Abdel-Aziz et al results who stated that infected groups treated with PZQ or MZ decreased significantly the IgG levels in an almost equal way (Aziz et al, 2006). Photomicrograph of control liver showing normal structure without depositions of collagenous fibers (2A), untreated infected mice liver displaying worm burden in the dilated portal vein (green arrow) and intense depositions of collagenous fibers in the fibro-celluar granuloma with eggs and complete formed miracidia (2B), infected mice liver treated with 600 mg/kg PZQ showing complete and partial destruction of eggs with less depositions of collagenous fibers in the granuloma (2C), infected mice liver treated with combined doses of PZQ and 150 mg/kg silymarin revealing minimized granuloma with complete destruction of eggs and a very small amount of collagenous fibers (2D), infected mice liver treated with 600 mg/kg MZ displaying granulomatous lesions with eggs and full complete miracidia with high content of collagenous fibers (black arrows), T.S.…”