Immune response, phagocytosis, and detoxication ability under the unfluence of peptide and amino acid preparations

Abstract

Dipeptides Glu-Trp and Lys-Asp and peptide mixtures of the 5th thymosine fraction, as well as thymaline, stimulate the immune response when applied subcutaneously during 5 days and intensify the activity of neutrophils and protect splenocytes from the toxic effect of benzene and aflatoxin B~ in vitro. Amino acids (Glu, Trp, Lys, Asp, and Arg) and amino acid mixtures (levamine-70, cerebrolysine, and aviamine) differently affect the indexes of specific and nonspecific resistance under the same conditions and at the same dose. Key Words: peptides; amino acids; immune response; phagocytosis; detoxicationChronic microbic and nonmicrobic intoxications are known to inhibit the factors of specific and nonspecific resistance, which promotes intercurrent infections [2,7]. For this reason the immunocorrection of such pathological states should include drugs with combined action of specific and nonspecific parameters of immune defense. Some peptides [3,9], amino acids, and their mixtures [1,4,8,9] are able to act upon certain chains of specific and nonspecific resistance, but the combination of these effects has not been studied.The aim of the present investigation was to examine the combined effects of some peptide and amino acid preparations on such indexes of specific and nonspecific resistance as the immune response, phagocytosis, and detoxication in vitro and in vivo.

Detoxication of benzene and aflatoxin B1 with amino acid and peptide preparations in mice and chicken

“…The data on antitoxic activity of natural immunomodulators, in particular amino acids and peptides. against benzene or AFB1 are scanty and obtained primarily in in vitro experiment [1,2,5].…”

Effect of syngeneic and xenogeneic apolipoprotein B-containing lipoproteins on immune response and phagocytosis in mice

“…On day 4 after intravenous immunization with sheep erythrocytes, antierythrocyte IgM-producing cells were counted in the spleen of each animal [6]. Phagocytic activity of peritoneal neutrophils in vitro [1] was expressed as phagocytic index, i.e., the percentage of phagocytizing neutrophils. One-day-old culture of St. aureus was used as the test microorganism.…”

Effect of Amino Acid on the Development Skin Tissue Organotypic Culture

“…Так, при исследовании показателей специфической и неспецифической резистентности установлено, что лизин, аргинин, глютаминовая и аспарагиновая кислоты, триптофан обладают разными иммуно-и фагоцитозстимулирующими и детоксицирующими свойствами. После их подкожного введения мышам лизин и аргинин только стимулировали фагоцитоз, но не защищали от токсических веществ, причем лизин не изменял иммунный ответ, а аргинин подавлял его [8].…”