Immune Response to <i>Babesia bigemina</i> Infection in Pregnant Cows

García, Tamara; Figueroa, Mariela; Ramos, Alfonso Peña; Rojas, M. C.; Canto, Armando; Falcón, Néstor; Alvarez, Mauricio

doi:10.1196/annals.1307.055

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Similar observations were noticed by Garcia et al (12), who showed that in cattle infected with Babesia bigemina, in contrast to in vitro conditions (7,8), no differences were observed in the levels of CD4+ and CD8+ lymphocytes in comparison with the healthy animals.…”

Section: Discussionsupporting

confidence: 90%

Quantitative Changes in Selected Lymphocyte Subpopulations after Administration of a Soluble Parasitic Antigen of Babesia Canis to Dogs

Adaszek

Lisiecka²,

Carbonero

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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Changes in selected blood lymphocyte subpopulations in dogs administered with a soluble parasitic antigen (SPA) derived from a supernatant of 18S RNA-A and 18S RNA-B Babesia canis cell culture were investigated. The studies included 20 dogs divided into three groups: group I (n=8) -comprised of dogs receiving SPA twice, at 3 week intervals; group II (n=5) -nonvaccinated control dogs, and group III (n=7) -dogs vaccinated twice with a commercial B. canis vaccine. Cytometric analysis revealed that vaccination with SPA derived from B. canis culture had similar effects to the vaccination with a commercial vaccine. The vaccination lowered the percentage of T lymphocytes (CD3+), T helper cells (CD4+), cytotoxic/supressor T cells (CD8+), B lymphocytes (CD21+), and MHC II lymphocytes in the blood in comparison to non-vaccinated dogs. Statistical analysis of the results demonstrated that mean values of the tested parameters at each stage of the study were similar in groups I and III and significantly higher in group II. The lowered level of the lymphocyte subpopulations in groups I and III persisted during the whole period of the study. The results presented that SPA has immunosuppressive effect in the first period after being administrated.

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Section: Discussionsupporting

confidence: 90%

Quantitative Changes in Selected Lymphocyte Subpopulations after Administration of a Soluble Parasitic Antigen of Babesia Canis to Dogs

Adaszek

Lisiecka²,

Carbonero

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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“…(16) showed that induction of the IL10 message in the spleen was followed by reduced levels of IL12, IFNγ and TNFα expression and that IL10 production was associated with the higher susceptibility to B. bovis of adult cattle compared with calves. The immune responses of cattle, during infection by B. bigemina , predominantly involved a Th1 response associated with the detection of IFNγ, TNFα and iNOS and no or weak detection of IL4 and IL10 (25). In our study, IFNγ production was not detected in PBMC supernatant from Babesia sp.…”

Section: Discussionmentioning

confidence: 99%

Course of infection byBabesiasp. BQ1 (Lintan) andB. divergensin sheep depends on the production of IFNγ and IL10

Guan

Chauvin

Yin

et al. 2010

Parasite Immunology

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Ovine babesiosis is an important disease in China and responsible for economic losses. Several Babesia strains are involved, but Babesia sp. BQ1 (Lintan) and Babesia sp. BQ1 (Ningxian) are particularly prevalent in the Guansu region. Babesia divergens, in contrast, can experimentally infect spleen-intact sheep, but does not induce clinical signs. The immune response of spleen-intact sheep to Babesia sp. BQ1 (Lintan) and to B. divergens was therefore compared to identify the immune mechanisms involved in pathogenicity. The greater pathogenicity of Babesia sp. BQ1 (Lintan) than that of B. divergens was confirmed: sheep infected with Babesia sp. BQ1 (Lintan), but not with B. divergens, developed hyperthermia and showed patent parasitaemia in Giemsa-stained blood smears from the ear vein. Furthermore, more parasites were also detected in the blood from the jugular vein of Babesia sp. BQ1 (Lintan)-infected sheep. Pathogenicity of Babesia spp. involved cellular responses, but not humoral responses. Interferon-gamma was produced only by specifically activated PBMC from B. divergens-infected sheep and interleukin-10 only by specifically activated PBMC from Babesia sp. BQ1 (Lintan)-infected sheep. The role of these cytokines in the course of infection by Babesia spp. is discussed.

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“…Anaplasma, Babesia, Ehrlichia and Theileria species are the most important tick-borne haemoparasites to livestock and wildlife worldwide (Kettle 1995;Sparagano et al 1999;Grootenhuis 2000;Steyl et al 2003;Nijhof et al 2003;Penzhorn 2006). The pathogenesis, immunology and pathological effects to susceptible animals have been extensively described (Morzaria 1989;Kettle 1995;Chansiri et al 1999;Grootenhuis 2000;Homer et al 2000;Nijhof et al 2003Nijhof et al , 2005Garcia et al 2004;Kocan et al 2004). …”

Section: Introductionmentioning

confidence: 96%

Molecular Detection ofAnaplasma, BabesiaandTheileriaSpecies in a Diversity of Tick Species from Ngorongoro Crater, Tanzania

Fyumagwa

Simmler

Meli

et al. 2011

South African Journal of Wildlife Research

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Immune Response to Babesia bigemina Infection in Pregnant Cows

Cited by 3 publications

References 12 publications

Quantitative Changes in Selected Lymphocyte Subpopulations after Administration of a Soluble Parasitic Antigen of Babesia Canis to Dogs

Quantitative Changes in Selected Lymphocyte Subpopulations after Administration of a Soluble Parasitic Antigen of Babesia Canis to Dogs

Course of infection byBabesiasp. BQ1 (Lintan) andB. divergensin sheep depends on the production of IFNγ and IL10

Molecular Detection ofAnaplasma, BabesiaandTheileriaSpecies in a Diversity of Tick Species from Ngorongoro Crater, Tanzania

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