Immune response to rabies vaccine in Thai dogs: A preliminary report

Tepsumethanon, Weera; Polsuwan, Chaiyaporn; Lumlertdaecha, Boonlert; Khawplod, Phakamatz; Hemachudha, Thiravat; Chutivongse, Supawat; Wilde, Henry; Chiewbamrungkiat, Montri; Phanuphak, Praphan

doi:10.1016/0264-410x(91)90186-a

Cited by 51 publications

(30 citation statements)

References 4 publications

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“…7 Data from owned dogs in Thailand and Java have shown that neutralizing antibody titers decrease very rapidly 60-120 days after vaccination to levels 5-25-fold less than the highest level reached. 18,19 Our study confirms the benefit of yearly booster vaccinations: the oldest dogs (group D), who had the benefit of several vaccinations before the survey, showed the highest titers, which lasted 1 year after vaccination. The higher level of neutralising antibodies obtained after several vaccinations has also been described by Sasaki and Gooch.…”

Section: Discussionsupporting

confidence: 75%

Rabies mass vaccination campaigns in Tunisia: are vaccinated dogs correctly immunized?

Seghaier¹,

Cliquet²,

Hammami³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. Among the 301 dogs vaccinated against rabies in a suburban area of Tunis, 165 were sero-surveyed for 13 months. One month after vaccination, 65% of the dogs less than 1 year of age and 76-84% of the older dogs had significant antibody titers. One month after annual revaccination, these percentages ranged between 92% and 100%. Puppies (less than 3 months old) responded to vaccination with no significant interference by passive maternal immunity. Based on these percentages, a 93% rate of protection may be expected for vaccinated dogs. This study confirms that all dogs (even those less than 3 months of age) must be vaccinated during mass campaigns. The expected protection conferred by locally produced potent vaccines reaches 79-99% based on the age of the dogs. The alleged relative inability of local dogs to respond to vaccination cannot explain the partial success of rabies control in Tunisia.

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Section: Discussionsupporting

confidence: 75%

Rabies mass vaccination campaigns in Tunisia: are vaccinated dogs correctly immunized?

Seghaier¹,

Cliquet²,

Hammami³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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“…In contrast, a study conducted in Thailand concluded that the administration of a single dose of tissue culture-derived rabies vaccine was not able to maintain significant rabies antibody titres over 1 year. Moreover, levels of vaccine-induced rabies antibodies were already very low as early as 60 days post-vaccination [7]. In Tunisia, the immunogenicity in dogs of lamb brain-derived rabies vaccine produced locally, was evaluated in field conditions [8].…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of specific ELISA and RFFIT antibody assays in the assessment of dog immunity against rabies

et al. 2005

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Two techniques are currently used to evaluate the humoral immune responses to rabies vaccination: ELISA, which detects binding antibodies to viral antigens and the WHO reference rapid fluorescent focus inhibition test (RFFIT), which assays in vitro virus-neutralizing antibodies. In this study, we have comparatively evaluated antibody responses of dogs reared either in an experimental kennel or living in field conditions after vaccination with a cell culture-derived rabies vaccine. In experimental conditions, both ELISA and RFFIT techniques were well correlated. However, in field conditions, they yielded discrepant results particularly in evaluating the residual rabies immunity before vaccine administration and in identifying seroconverted dogs. After rabies vaccination in field conditions, while similar antibody titres and seroconversion rates were obtained using either technique, the discrimination of a given dog according to the seroconversion threshold depended on the assay. We concluded, that whereas in experimental conditions, ELISA and RFFIT were well correlated, in field conditions ELISA yielded upper estimates. Consequently, RFFIT, although a cumbersome test, should continue to be considered as the reference rabies antibody assay technique. A seroconversion threshold of 0.5 IU/ml should be cautiously considered and a higher threshold (1 IU/ml) could be more appropriate in the evaluation of rabies immunity in the field in order to marginalize the interfering factors.

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“…Many countries have currently accepted the tests to replace or alleviate a long‐term quarantine. The tests are also used for the serological survey for mass vaccination of dogs (Seghaier et al., 1999; Tepsumethanon et al., 1991). In Japan, the VNT‐IIP has been used for field researches or quality controls of veterinary vaccine (Hirayama et al., 1990; Shimazaki et al., 2003).…”

Section: Resultsmentioning

confidence: 99%

Validation and Standardization of Virus Neutralizing Test Using Indirect Immunoperoxidase Technique for the Quantification of Antibodies to Rabies Virus

Ogawa

Gamoh

Aoki

et al. 2008

Zoonoses and Public Health

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A virus neutralizing test using an indirect immunoperoxidase technique (VNT-IIP) for rabies has been developed for the titration of dog and cat serum samples in Japan. The VNT-IIP has the advantage that results obtained can be viewed by the naked eye. The purpose of this study was to validate the VNT-IIP and compare it with one of the international standard methods, the fluorescent antibody virus neutralization test (FAVNT). The VNT-IIP showed satisfactory repeatability, high analytical specificity and good accuracy. Regarding the comparison between the VNT-IIP and the FAVNT, the VNT-IIP showed good agreement (91.9%), high sensitivity (92.8%) as well as specificity (87.0%) and good correlation (r = 0.92). As described above, the validation of the VNT-IIP was satisfactory and the performances of the test proved to be equivalent to those of an international standard method.

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Immune response to rabies vaccine in Thai dogs: A preliminary report

Cited by 51 publications

References 4 publications

Rabies mass vaccination campaigns in Tunisia: are vaccinated dogs correctly immunized?

Rabies mass vaccination campaigns in Tunisia: are vaccinated dogs correctly immunized?

Comparative evaluation of specific ELISA and RFFIT antibody assays in the assessment of dog immunity against rabies

Validation and Standardization of Virus Neutralizing Test Using Indirect Immunoperoxidase Technique for the Quantification of Antibodies to Rabies Virus

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