Immune responses induced in individuals with dual infection Tuberculosis (TB) and HIV during antiretroviral and TB therapy

Nosik, Marina; Rymanova, I.; Lobach, Olga; Sevostyanihin, S.; Киселева, И. А.; Adamovich, N.; Sobkin, Alexandr

doi:10.1016/j.ijid.2016.11.216

Cited by 2 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The circulating plasma levels of TNF-α cytokine were found to be significantly lower in the TB-HIV group compared to the TB group, as has been reported in other studies 4 , 20 . The decreased levels of TNF-α cytokine in the TB-HIV group may be due to a more pronounced reduction of CD4+, CD8+ and macrophages, which will in turn decrease the production of TNF-α cytokine.…”

Section: Discussionsupporting

confidence: 87%

“…Although the study found higher levels of TNF-α in the TB-infected group than among the HC, levels of significant difference were not found. Several previous studies have found increased plasma levels of TNF-α in TB disease compared to control groups 4 , 12 - 14 . It is important to note that participants in the control group in this study were much older than those in the TB group.…”

Section: Discussionmentioning

confidence: 79%

“…There was no difference in the plasma levels of TNF-α cytokine between the TB-HIV group and HIV groups in this study. Studies have noted the influence of ART usage in reducing the expression of pro-inflammatory cytokines in HIV-infected patients, and it has also been reported that the influence of ART dominates in dually infected participants 4,14,22 . This may possibly be the reason why there were no differences in the TNF-α expression between the HIV and TB-HIV infection groups in this study.…”

Section: Discussionmentioning

confidence: 99%

“…South Africa is one of only six countries which account for two-thirds of all active TB cases 3 . Studies also indicate that TB-infected preg-nant women may have a 32-fold increased risk of death if co-infected with HIV 4 . To reduce the burden of TB and the progression of HIV infections, it is necessary to identify individuals at high risk 5 .…”

Section: Introductionmentioning

confidence: 99%

“…South Africa is one of only six countries which account for two-thirds of all active TB cases 3 . Studies also indicate that TB-infected pregnant women may have a 32-fold increased risk of death if co-infected with HIV 4 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effects of SNPs on TNF-α and IL-10 cytokine expression in TB and HIV patients in the Capricorn district, Limpopo Province, South Africa

A Manabile,

C Maguga-Phasha,

E Makgatho

2024

Afr H. Sci.

View full text Add to dashboard Cite

Background: The impact of Tuberculosis (TB) places an immense burden on the health care system. Infection with HumanImmunodeficiency Virus (HIV) is a significant risk factor in the development and progression of TB disease. Single NucleotidePolymorphisms (SNPs) in the promoter region of Interleukin-10 (IL-10) and Tumour Necrotic Factor-Alpha (TNF-α) may playa major role in the disease mechanism and understanding these mechanisms might prove to be a useful diagnostic tool in evaluatingthe immune regulation and progression of the disease. Objective: This study aimed to determine the relationship between cytokine levels and gene variants of Interleukin-10 and TumourNecrotic Factor Alpha in TB and HIV-infected participants. Methods: Cytokine levels were determined by ELISA, and SNPs were determined by MassArray®. Results: The levels of TNF-α were higher in the TB group than the HIV (p < 0.001) and TB-HIV (p = 0.011) groups, but similar to the TNF-α levels in the control group. In the HIV group, IL-10 levels were higher than those of the TB (p < 0.001) and control groups (p = 0.039), whereas there was no difference between the IL-10 levels in the HIV and the TB-HIV infection groups. The ratio was determined and there were no differences between the four infection groups. In this study, no associations were detected between the circulating plasma levels of TNF-α and IL-10 and their genotypes. Conclusion: Our data showed that the gene variants were not associated with circulating plasma levels of TNF-α and IL-10 in our study population. A pro-inflammatory environment was found in the TB and TB-HIV groups, which is suggesting of bacterial clearance, while an anti-inflammatory environment was found in the HIV group, which suggests the suppression ofviral replication. Keywords: Tuberculosis; Human immunodeficiency virus; interleukin-10.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of SNPs on TNF-α and IL-10 cytokine expression in TB and HIV patients in the Capricorn district, Limpopo Province, South Africa

A Manabile,

C Maguga-Phasha,

E Makgatho

2024

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

Dynamics of Plasmatic Levels of Pro- and Anti-Inflammatory Cytokines in HIV-Infected Individuals with M. tuberculosis Co-Infection

Nosik

Ryzhov

Rymanova³

et al. 2021

Microorganisms

View full text Add to dashboard Cite

Tuberculosis (TB) and HIV have profound effects on the immune system, which can lead to the activation of viral replication and negatively regulate the activation of T cells. Dysregulation in the production of cytokines necessary to fight HIV and M. tuberculosis may ultimately affect the results of the treatment and be important in the pathogenesis of HIV infection and TB. This work presents the results of a study of the expression of pro- and anti-inflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-1RA) in drug-naïve patients with dual infection of HIV/TB at the late stages of HIV-infection, with newly diagnosed HIV and TB, and previously untreated HIV in the process of receiving antiretroviral (ART) and TB treatment vs. a cohort of patients with HIV monoinfection and TB monoinfection. The study revealed that during a double HIV/TB infection, both Th1 and Th2 immune responses are suppressed, and a prolonged dysregulation of the immune response and an increased severity of the disease in pulmonary/extrapulmonary tuberculosis is observed in HIV/TB co-infection. Moreover, it was revealed that a double HIV/TB infection is characterized by delayed and incomplete recovery of immune activity. High levels of IL-6 were detected in patients with HIV/TB co-infection before initiation of dual therapy (2.1-fold increase vs. HIV), which persisted even after 6 months of treatment (8.96-fold increase vs. HIV), unlike other cytokines. The persistent enhanced expression of IL-6 in patients with dual HIV/TB co-infection allows the consideration of it as a potential marker of early detection of M. tuberculosis infection in HIV-infected individuals. The results of multivariate regression analysis showed a statistical trend towards an increase in the incidence of IRIS in patients with high IL-1Ra levels (in the range of 1550–2500 pg/mL): OR = 4.3 (95%CI 3.7–14.12, p = 0.53), which also allows IL-1Ra to be considered as a potential predictive biomarker of the development of TB-IRIS and treatment outcomes.

show abstract

Immune responses induced in individuals with dual infection Tuberculosis (TB) and HIV during antiretroviral and TB therapy

Cited by 2 publications

References 0 publications

Effects of SNPs on TNF-α and IL-10 cytokine expression in TB and HIV patients in the Capricorn district, Limpopo Province, South Africa

Effects of SNPs on TNF-α and IL-10 cytokine expression in TB and HIV patients in the Capricorn district, Limpopo Province, South Africa

Dynamics of Plasmatic Levels of Pro- and Anti-Inflammatory Cytokines in HIV-Infected Individuals with M. tuberculosis Co-Infection

Contact Info

Product

Resources

About