Immune signature atlas of vaccines: learning from the good responders

An Overview of Current Accomplishments and Gaps of COVID-19 Vaccine Platforms and Considerations for Next Generation Vaccines

“…The mechanisms involved in enhanced immune responses are dependent on the nature of booster doses using homologous vectors (and antigens) versus heterologous vectors. The correlations between the two could be elucidated using methods of design of experiment (DOE), and neural network of systems immunology 23 28 . As stated above, induction of the diverse immune responses that confer long-term immune memory against different strains of the virus can be studied by investigation of different prime boost regimens.…”

Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

“…Of the 13 vaccines, these spanned several vaccine platforms including live attenuated virus, inactivated virus, recombinant viral vector, recombinant protein, and bacterial glycoconjugate vaccines. 69 , 70 …”

“…These metabolic genes regulated by NF-κB are critical for innate and adaptive immune responses such as antiviral responses, antigen presentation, and B cell activation. 69 , 70 Individuals in the high inflammatory endotype upregulated expression of transcriptomic markers of classical monocytes and DCs, which are associated with greater serum antibody responses. Contrary to the aforementioned studies, 74 , 75 this suggests that baseline heightened innate immune activation mediated by monocytes and DCs favors vaccine-specific antibody production likely by aiding in germinal center reactions necessary for high-affinity antibodies.…”

“…Contrary to the aforementioned studies, 74 , 75 this suggests that baseline heightened innate immune activation mediated by monocytes and DCs favors vaccine-specific antibody production likely by aiding in germinal center reactions necessary for high-affinity antibodies. 69 , 70 It is possible that pre-vaccination inflammation is a delicate balance where some can be beneficial to driving vaccine responses and excess can be detrimental. Nonetheless, these studies demonstrate that the innate immune landscape prior to vaccination affects vaccine induced immune responses.…”

Impfen 2023

“…Sie gelten bis zum Beweis des Gegenteils als Ausdruck einer Immundefizienz und sollten daher immer genetisch-immunologisch abgeklärt werden. Unser zunehmendes Verständnis der "spezifischen Impfimmunität" (Impfimmunsignatur: differenzielle Expression von für die Impfimmunreaktion relevanter Gene) wird hoffentlich dazu beitragen, in der Zukunft noch wirksamere, aber gleichzeitig nebenwirkungsärmere Impfstoffe zu entwickeln [2].…”