Immune status during postpartum, peri-implantation and early pregnancy in cattle: An updated view

Velázquez, Melisa María del Luján; Peralta, María Belén; Angeli, Emmanuel; Stassi, Antonela Florencia; Gareis, Natalia Carolina; Durante, Leandro Iván; Cainelli, S.; Salvetti, Natalia Raquel; Rey, Florencia; Ortega, Hugo Héctor

doi:10.1016/j.anireprosci.2019.05.010

Cited by 29 publications

(25 citation statements)

References 116 publications

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“…Therefore, have those cells in the uterine environment could be helpful to the pregnancy establishment. In front all evidence presented here, is clear that, the maternal immune system during pregnancy is not suppressed, but its immune functions in the uterus are strongly modulated (Velázquez et al, 2019).…”

Section: Immune System and Early Pregnancymentioning

confidence: 56%

“…When IFN-τ binds IFNAR in the endometrial tissue, beyond the classic ISG, monocyte chemoattractant protein 1 (MCP1) and MCP2 are up regulated (Mansouri-Attia et al, 2012). Both proteins are potent chemotactic factors for monocytes, which is one of the most important cell types during the immune maternal response to the embryo in cattle (Kamat et al, 2016;Velázquez et al, 2019). The maternal innate immune response is also regulated by the embryo as indicated by a down regulation of interleukin 1β (IL1β) and nuclear factor-ҡβ (NF-ҡβ) system (Muñoz et al, 2012).…”

Section: Immune System and Early Pregnancymentioning

confidence: 99%

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Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

et al. 2021

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This review focuses on the innate immune events modulated by conceptus signaling during early pregnancy in ruminants. Interferon-tau (IFN-τ) plays a role in the recognition of pregnancy in ruminants, which involves more than the inhibition of luteolytic pulses of PGF2α to maintain corpus luteum function. For successful pregnancy establishment, the allogenic conceptus needs to prevent rejection by the female. Therefore, IFN-τ exerts paracrine and endocrine actions to regulate the innate immune system and prevent conceptus rejection. Additionally, other immune regulators work in parallel with IFN-τ, such as the pattern recognition receptors (PRR). These receptors are activated during viral and bacterial infections and in early pregnancy, but it remains unknown whether PPR expression and function are controlled by IFN-τ. Therefore, this review focuses on the main components of the innate immune response that are involved with early pregnancy and their importance to avoid conceptus rejection.

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Section: Immune System and Early Pregnancymentioning

confidence: 56%

Section: Immune System and Early Pregnancymentioning

confidence: 99%

Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

et al. 2021

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“…Significant advances have been made over the last 30 years with respect to efficiencies of production in dairy cattle. However, there are several problems in dairy production that require a solution; these include immunity (poor udder health [44], poor reproduction (low conception rate, retained placenta, metritis, cystic ovaries [45,46,47] and reduced calf viability in early postnatal life [48].…”

Section: Oxidative Stress In Dairy Cattlementioning

confidence: 99%

Revisiting Oxidative Stress and the Use of Organic Selenium in Dairy Cow Nutrition

Surai

Kochish

Фисинин

et al. 2019

Animals

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In commercial animals production, productive stress can negatively impact health status and subsequent productive and reproductive performance. A great body of evidence has demonstrated that as a consequence of productive stress, an overproduction of free radicals, disturbance of redox balance/signaling, and oxidative stress were observed. There is a range of antioxidants that can be supplied with animal feed to help build and maintain the antioxidant defense system of the body responsible for prevention of the damaging effects of free radicals and the toxic products of their metabolism. Among feed-derived antioxidants, selenium (Se) was shown to have a special place as an essential part of 25 selenoproteins identified in animals. There is a comprehensive body of research in monogastric species that clearly shows that Se bioavailability within the diet is very much dependent on the form of the element used. Organic Se, in the form of selenomethionine (SeMet), has been reported to be a much more effective Se source when compared with mineral forms such as sodium selenite or selenate. It has been proposed that one of the main advantages of organic Se in pig and poultry nutrition is the non-specific incorporation of SeMet into general body proteins, thus forming an endogenous Se reserve that can be utilized during periods of stress for additional synthesis of selenoproteins. Responses in ruminant species to supplementary Se tend to be much more variable than those reported in monogastric species, and much of this variability may be a consequence of the different fates of Se forms in the rumen following ingestion. It is likely that the reducing conditions found in the rumen are responsible for the markedly lower assimilation of inorganic forms of Se, thus predisposing selenite-fed animals to potential Se inadequacy that may in turn compromise animal health and production. A growing body of evidence demonstrates that organic Se has a number of benefits, particularly in dairy and beef animals; these include improved Se and antioxidant status and better Se transfer via the placenta, colostrum, and milk to the newborn. However, there is a paucity in the data concerning molecular mechanisms of SeMet assimilation, metabolism and selenoprotein synthesis regulation in ruminant animals, and as such, further investigation is required.

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“…Among the 18 mares, three mares, F, J and M, were maidens and did not show clinical signs of ECE. In general, mucosal immune defenses, including innate immunity, are thought to be depressed during the postpartum period [9,19]. One possibility is that the three maidens were relatively resistant against microbial infections, including EHV-3 infection, compared with postpartum mares in the breeding season.…”

Section: Some Cases Of Ece Have Recently Been Observed In Thoroughbrementioning

confidence: 99%

Period of excretion of equine herpesvirus 3 (EHV-3) from a stallion before showing clinical signs of equine coital exanthema and the effect of acyclovir treatment on the duration of EHV-3 excretion

Toishi¹,

Tsunoda²,

Kirisawa

2020

The Journal of Veterinary Medical Science

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In 2017, two Thoroughbred stallions, A and B in Farms A and B, respectively, in Hokkaido in Japan showed clinical signs of equine coital exanthema (ECE). In 2020, stallion C in Farm B showed clinical signs of ECE. Eighteen mares were mated within five days before stallion A developed ECE. Ten mares that mated within 3 days before onset showed clinical signs of ECE on the external genitalia. Equine herpesvirus 3 (EHV-3) was isolated from vaginal swabs from three mares that mated within 2 days before onset. Swabs from 12 mares that mated within 4 days before onset were real-time PCR (rPCR)-positive and nine of those mares had an increased EHV-3 antibody titer. The three stallions were administered valaciclovir orally and topical acyclovir ointment was applied. Treatment started on the next day after onset in stallion A and on the day of onset in stallions B and C. EHV-3 was firstly isolated from penis swabs of stallions A and B before treatment and from penis swabs of stallion C 2 days after treatment. EHV-3 was not isolated after 8, 5 and 8 days from onset in stallions A, B and C, respectively. However, swabs were rPCRpositive for at least 12, 9 and 15 days after onset of stallions A, B and C, respectively. EHV-3 was excreted from the stallions at least within 4 days before the onset of ECE, and acyclovir treatment resulted in the termination of excretion within 8 days after onset.

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Immune status during postpartum, peri-implantation and early pregnancy in cattle: An updated view

Cited by 29 publications

References 116 publications

Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

Revisiting Oxidative Stress and the Use of Organic Selenium in Dairy Cow Nutrition

Period of excretion of equine herpesvirus 3 (EHV-3) from a stallion before showing clinical signs of equine coital exanthema and the effect of acyclovir treatment on the duration of EHV-3 excretion

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