Immune status of children on continuous ambulatory peritoneal dialysis

Hisano, Satoshi; Miyazaki, Chiaki; Hatae, Ken; Kaku, Yoshitsugu; Yamane, Ichiroh; Ueda, Kohji; Okamua, Seiichi

doi:10.1007/bf00866308

Cited by 23 publications

(16 citation statements)

References 10 publications

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“…In our CAPD patients, the levels of IgG, IgA, and IgM were decreased as compared with those of the controls. In accordance with the literature [8, 15], the fall in IgG was more significant.…”

Section: Discussionsupporting

confidence: 80%

“…The results of the present study together with those of others reported so far [6, 7, 8, 9, 10, 11, 12, 14]suggest that children with CRF are not immunocompromised, though the effects of uraemia may change various components of their immune system.…”

Section: Discussionsupporting

confidence: 63%

“…Measurement of serum immunoglobulins in uraemic patients revealed normal levels [3], in parallel with our results in haemodialysis and predialysis groups. However, studies have shown that the serum immunoglobulin levels may be low due to the loss of immunoglobulins by the peritoneal route in uraemic children on CAPD [8, 15]. In our CAPD patients, the levels of IgG, IgA, and IgM were decreased as compared with those of the controls.…”

Section: Discussionmentioning

confidence: 69%

“…According to these studies, adults with chronic renal failure (CRF) showed an impaired immune status and a poor immunological response to vaccination [1, 2, 3, 4, 5]. However, in uraemic children, these findings appear to be different from those of adults [2, 6, 7, 8, 9, 10, 11, 12]. …”

Section: Introductionmentioning

confidence: 92%

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Are Uraemic Children Immunologically Compromised?

Ensari¹,

Ekı̇m²,

İkincioğulları³

et al. 2001

Nephron

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Background: Various immunological abnormalities leading to impaired immune status have been described in uraemic adults; however, few data are available for uraemic children. Methods: In this study, peripheral blood total lymphocyte count and lymphocyte subsets (CD3+, CD4+, CD8+, CD16+, CD20+) were evaluated, skin tests with PPD and Candida antigens were performed, and serum immunoglobulin (IgG, IgA, IgM) and complement (C3, C4) levels were measured in 30 children with end-stage renal failure (10 before dialysis, 10 on continuous ambulatory peritoneal dialysis, and 10 on haemodialysis) and the results compared with those of 15 healthy controls. Results: The data showed significant lymphopenia in predialysis and haemodialysis groups. No significant change was observed in the CD4+/CD8+ ratio or in the percentages of lymphocyte subsets in either group studied, while the absolute values of some lymphocyte subsets were significantly lower in all groups as compared with controls. In skin test evaluation, only the patients in the predialysis group showed a significantly decreased response to Candida antigen. The serum immunoglobulin levels were significantly decreased in the continuous ambulatory peritoneal dialysis group as compared with the control group. Conclusion: Our results, together with those of other paediatric studies, reported in the literature, suggest that uraemic children are not immunocompromised, though the effects of uraemia may cause some variation in their immune status.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 92%

See 2 more Smart Citations

Are Uraemic Children Immunologically Compromised?

Ensari¹,

Ekı̇m²,

İkincioğulları³

et al. 2001

Nephron

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“…Ancak IgG düzeyinin total olarak eksikliğinin mi yoksa subgruplarının eksikliğinin mi peritonite yatkınlık yarattığı tam olarak bilinmemektedir. IgG'nin 4 ayrı subgrubu mevcuttur ve subgrup eksikliği olanlarda total IgG düzeyleri normal olabilir (7). IgG subgruplarının eksikliğinde antikor yanıtları bozulmakta ve enfeksiyona eğilim ortaya çıkmakta, sık ve ciddi piyojenik enfeksiyonlar gözlenmektedir (8).…”

Section: Sarıkaya M Ve Ark: Sapd Hastalarında Peritonitunclassified

Sürekli Ayaktan Periton Diyaliz Hastalarında Peritonit ve Serum-Diyalizat İmmünglobulin-G Subgrup Düzeyleri İlişkisi

Sarıkaya¹,

Şahintürk²,

İnci³

2017

Turk Neph Dial Transpl

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ÖzAMAÇ: Peritonit, Sürekli Ayaktan Periton Diyaliz (SAPD) tedavisinin en önemli komplikasyonudur. Peritoneal savunma sisteminin önemli elementi IgG ve subgruplarıdır. IgG subgrupları eksikliği tekrarlayan infeksiyonlara eğilimle sonuçlanması nedeniyle serum ve diyalizatta IgG subgruplarının düzeylerinin peritonit sıklığı ile ilişkisinin araştırılması amaçlandı. GErEÇ ve yÖntEMLEr:Çalışmaya 30 SAPD hastası alındı. Hastalar yıllık peritonit sıklığına göre iki gruba ayrıldı. Yılda iki veya daha fazla sayıda peritonit atağı geçiren hastalar high peritonitis index (HPI), yılda bir veya hiç peritonit geçirmeyenler ise low peritonitis index (LPI) olarak gruplandırıldı. 17 (%56,67) hasta LPI, 13 (%43,33) hasta HPI grubuna dahil edildi. İki grup IgG subgrup düzeyi açısından karşılaştırıldı.BULGULAr: Her iki grupta serum IgG subgrupları karşılaştırıldığında anlamlı fark saptanmadı (p IgG1:0,86, IgG2:0,93, IgG3:0,4, IgG4:0,67, total IgG:0,80 mg/ml). Diyalizat IgG subgruplarının HPI grubunda anlamlı düzeyde yüksek olduğu görüldü (p IgG1:0,006, IgG2:0,01, IgG3:0,007, IgG4:0,01, total IgG:0,003 mg/ml). HPI grubunda diyalizat total protein, globulin ve albumin kayıp düzeyleri LPI grubuna göre belirgin olarak yüksek bulundu (sırasıyla p=0,39, 0,26, 0,01).SOnUÇ: HPI olgularında IgG subgrupları düzeylerinin LPI olgularına göre yüksek olmasının nedeni, tekrarlayan peritonitler sonucunda periton membranındaki yapısal değişikliklere bağlı artmış makro molekül kaybı ve gelişen inflamatuvar bir yanıt olabilir. Sonuçlarımız IgG subgrup düzeyleri eksikliğinin peritonit gelişiminde önemli bir rol oynamadığını düşündürmektedir.AnAhtAr SÖzcükLEr: Sürekli ayaktan periton diyalizi, Peritonit, IgG subgrupları ABStrAct OBJEctIVE: Peritonitis is the most important complication of Continuous Ambulatory Peritoneal Dialysis (CAPD) treatment. The most powerful defending elements of peritoneal fluid are IgG and the IgG subclasses. Low levels of IgG subclasses result in recurrent infections. We therefore aimed to investigate the peritonitis frequency and serum-dialysate IgG subclass level relationship. MAtErIAL and MEthODS:A total of 30 CAPD patients were included in this study. The patients were divided into two groups according to their peritonitis frequency. Patients with two or more peritonitis attack were grouped as High Peritonitis Index (HPI) and those with one or less peritonitis attack as Low Peritonitis Index (LPI). 17 (56.67%) patients were in the LPI and 13 (43.33%) patients in the HPI group. These two groups were compared for their IgG subclass levels.rESULtS: There was no significant difference for serum IgG and subclass levels (p IgG1:0.86, IgG2:0.93, IgG3:0.4, IgG4:0.67, total IgG:0.80 mg/ml). Dialysate IgG and subclass levels were significantly higher in the HPI group (p IgG1:0.006, IgG2:0.01, IgG3:0.007, IgG4:0.01, total IgG:0.003 mg/ml). The loss of total protein, albumin and globulin in the dialysate was significantly higher in the HPI group (respectively p=0.39, 0.26, 0.01).cOncLUSIOn: Structural changes in the peritoneal membra...

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Immune Function and Immunizations in Dialyzed Children

Chua

Neu

2011

Pediatric Dialysis

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Immune status of children on continuous ambulatory peritoneal dialysis

Cited by 23 publications

References 10 publications

Are Uraemic Children Immunologically Compromised?

Are Uraemic Children Immunologically Compromised?

Sürekli Ayaktan Periton Diyaliz Hastalarında Peritonit ve Serum-Diyalizat İmmünglobulin-G Subgrup Düzeyleri İlişkisi

Immune Function and Immunizations in Dialyzed Children

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