Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction

Chandrasekaran, Chinampudur V; Sundarajan, K.; Edwin, Jothie Richard; Gururaja, Giligar M; Mundkinajeddu, Deepak; Agarwal, Amit

doi:10.4103/0974-8490.110527

Cited by 95 publications

(68 citation statements)

References 33 publications

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“…Support for the later explanation can be found in our previous studies examining the effects of turmeric extracts in this same model of RA; only turmeric extracts containing polar compounds were capable of inhibiting granulomatous inflammation [7,10]. Immunomodulatory effects of polysaccharide moieties have previously been reported in other settings [31-33]. In the context of RA, where reactivation of tuberculosis has been reported in response to certain anti-inflammatory treatments [16], inhibition of the protective granulomatous response by ginger- (or turmeric-) derived polysaccharides could similarly result in untoward clinical effects, making polysaccharide-containing ginger extracts less desirable.…”

Section: Discussionsupporting

confidence: 61%

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

et al. 2016

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Ginger and its extracts have been used traditionally as anti-inflammatory remedies, with a particular focus on the medicinal properties of its phenolic secondary metabolites, the gingerols. Consistent with these uses, potent anti-arthritic effects of gingerol-containing extracts were previously demonstrated by our laboratory using an experimental model of rheumatoid arthritis, streptococcal cell wall (SCW)-induced arthritis. In this study, anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), which contain terpenes with reported phytoestrogenic activity, were assessed in female Lewis rats with SCW-induced arthritis. GEO (28 mg/kg/d ip) prevented chronic joint inflammation, but altered neither the initial acute phase of joint swelling nor granuloma formation at sites of SCW deposition in liver. Pharmacologic doses of 17-β estradiol (200 or 600 μg/kg/d sc) elicited the same pattern of anti-inflammatory activity, suggesting that GEO could be acting as a phytoestrogen. However, contrary to this hypothesis, GEO had no in vivo effect on classic estrogen target organs, such as uterus or bone. En toto, these results suggest that ginger's anti-inflammatory properties are not limited to the frequently studied phenolics, but may be attributable to the combined effects of both secondary metabolites, the pungent-tasting gingerols and as well as its aromatic essential oils.

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Section: Discussionsupporting

confidence: 61%

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

et al. 2016

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“…Curcuminoids have a series of biological activities, including immunomodulation and anti-inflammatory activity (28). Recently, curcuminoids were reported to show in vitro antileishmanial activity against L. major (19), making them suitable candidates as antileishmanial agents.…”

Section: Discussionmentioning

confidence: 99%

Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis

Tiwari

Pahuja

Kumar

et al. 2017

Antimicrob Agents Chemother

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Leishmaniasis chemotherapy remains very challenging due to high cost of the drug and its associated toxicity and drug resistance, which develops over a period of time. Combination therapies (CT) are now in use to treat many diseases, such as cancer and malaria, since it is more effective and affordable than monotherapy. CT are believed to represent a new explorable strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite Leishmania. In the present study, we investigated the effect of a combination of a traditional Indian medicine (ayurveda), a natural product curcumin and miltefosine, the only oral drug for visceral leishmaniasis (VL) using a Leishmania donovani-hamster model. We developed an oral nanoparticle-based formulation of curcumin. Nanoformulation of curcumin alone exhibited significant leishmanicidal activity both in vitro and in vivo. In combination with miltefosine, it exhibited a synergistic effect on both promastigotes and amastigotes under in vitro conditions. The combination of these two agents also demonstrated increased in vivo leishmanicidal activity accompanied by increased production of toxic reactive oxygen/nitrogen metabolites and enhanced phagocytic activity. The combination also exhibited increased lymphocyte proliferation. The present study thus establishes the possible use of nanocurcumin as an adjunct to antileishmanial chemotherapy.

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“…The pouch fluid volume was also significantly reduced by CF-AECal. This reduction in transudate and granuloma formation may correlate with the ability of the plant extract to inhibit collagen and mucopolysaccharides synthesis and reduce the number of fibroblasts involved in the formation of granuloma tissue (Mallat et al, 1995;Chandrasekaran et al, 2013). The migration of leukocytes at the site of inflammation is an important parameter in the inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Acute and Subacute Anti-Inflammatory Activities of Dichloromethane Extract of Cassia Alata (Linn.) Leaves in Wistar Rats

F.L¹,

A.B²,

G.R³

et al. 2017

AJTCAM

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Background: In Burkina Faso, leaves of Cassia alata are used in the treatment of several diseases, including inflammation. This study evaluated the anti-inflammatory effects of the dichloromethane extract of Cassia alata leaves (CF-AECal) on different models of inflammation in wistar rats in order to enhance its use in traditional medicine. Materials and Methods: Acute inflammation was induced among rats with 0.1 ml of carrageenan, serotonin, histamine and dextrane 1%. The effects of the CF-AECal 50 mg/kg and 100 mg/kg were compared to the effects of diclofenal 5 mg/kg, prednisone 5 mg/kg, promethazine 1 mg/kg, cyproheptadin 2 mg/kg. Cotton pellet and air pouchinduced granuloma permitted to study CF-AECal effects on the subacute inflammation. The ways of administrations were intra peritoneal for the substances of inductions and oral for the molecules of references and CF-AECal. Result: Carrageenan-induced paw edema has been inhibited to 52.39% by CF-AECal 50 mg/kg and 50.17% by CFAECal 100 mg/kg. Wet granulomas formation has been inhibited by CF-AECal 50 and 100 mg/kg to 20.94 and 57.82%. The dry granulomas were inhibited at 24.32 and 59.04% by CF-AECal 50 and 100 mg/kg. Air pouch fluid was significantly reduced by CF-AECal in comparison to the control group. There was a massive recruitment of leukocytes in the pocket granuloma of the control group. CF-AECal caused strong inhibition of this infiltration of leukocytes (p< 0.001). Conclusion: Dichloromethane extract of Cassia alata showed anti-inflammatory effects.

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Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction

Cited by 95 publications

References 33 publications

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis

Acute and Subacute Anti-Inflammatory Activities of Dichloromethane Extract of Cassia Alata (Linn.) Leaves in Wistar Rats

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