Immune thrombocytopenia associated with malaria: a case report

Miloudi, Mouhcine; Sbaai, Mohammed; Fatihi, J.

doi:10.1684/abc.2017.1280

Cited by 2 publications

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“…Possible causes of thrombocytopenia during malaria include reduced platelet survival from peripheral destruction, enhanced sequestration, and decreased platelet production [25,26]. It has been described that thrombocytopenia could lead to increased replication of parasites by either decreased parasite killing or decreasing activation of the immune response, as shown by the negative correlation between parasitemia and platelet count [27,28].…”

Section: Discussionmentioning

confidence: 99%

Effects of Gymnema inodorum Leaf Extract on the Alteration of Blood Coagulation Parameters and Platelet Count in Plasmodium berghei-Infected Mice

Boonyapranai

Sarakul

Somsak

et al. 2022

Journal of Parasitology Research

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Malaria remains highly prevalent and one of the major causes of morbidity and mortality in tropical and subtropical regions. Alteration of blood coagulation and platelets has played an important role and attributed to increased morbidity in malaria. Hence, this study was performed to investigate the efficacy of Gymnema inodorum leaf extract on Plasmodium berghei-induced alteration of blood coagulation parameters and platelet numbers in mice. Groups of ICR mice were inoculated with 1 × 10 7 parasitized red blood cells of P. berghei ANKA (PbANKA) and given orally by gavage with 100, 250, and 500 mg/kg of G. inodorum leaf extract (GIE). Chloroquine (10 mg/kg) was used as a positive control. Platelet count and blood coagulation parameters were measured. The results showed that PbANKA induced thrombocytopenia in mice as indicated by markedly decreased platelet count. Decreased platelet count had a negative correlation with the degree of parasitemia with R 2 value of 0.6668. Moreover, significantly ( p < 0.05 ) shortened activated partial thromboplastin time was found in PbANKA-infected group, while prothrombin time and thrombin time were still normal. GIE gave significantly ( p < 0.05 ) good results with respect to platelet count, compared with the results obtained from positive and healthy controls. Additionally, GIE reversed the alteration of blood coagulation parameters when compared to untreated mice. The highest efficacy of GIE was observed at a dose of 500 mg/kg. It was concluded that GIE exerted a protective effect on thrombocytopenia and altered blood coagulation parameters induced by PbANKA infection in mice. This plant may be a future candidate for alternative antimalarial development.

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Section: Discussionmentioning

confidence: 99%

Effects of Gymnema inodorum Leaf Extract on the Alteration of Blood Coagulation Parameters and Platelet Count in Plasmodium berghei-Infected Mice

Boonyapranai

Sarakul

Somsak

et al. 2022

Journal of Parasitology Research

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Divergent Roles of Antiself Antibodies during Infection

Rivera-Correa

Rodrı́guez

2018

Trends in Immunology

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Antiself antibodies are most commonly associated with autoimmune disorders, but a large body of evidence indicates that they are also present in numerous infectious diseases. These autoimmune antibodies appear transiently during infection with a number of viruses, bacteria, and parasites and in some cases have been associated with the development of autoimmune disorders that develop after infection has been cleared. Traditionally these infection-associated autoantibodies are considered an erroneous byproduct of a legitimate immune response, but their possible role in the clearance of microbes and infected cells or inhibition of host-cell invasion suggests that they may be present because of their beneficial protective role against various infections.

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Immune thrombocytopenia associated with malaria: a case report

Cited by 2 publications

References 0 publications

Effects of Gymnema inodorum Leaf Extract on the Alteration of Blood Coagulation Parameters and Platelet Count in Plasmodium berghei-Infected Mice

Effects of Gymnema inodorum Leaf Extract on the Alteration of Blood Coagulation Parameters and Platelet Count in Plasmodium berghei-Infected Mice

Divergent Roles of Antiself Antibodies during Infection

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