2006
DOI: 10.1182/blood-2006-03-010405
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Immune thrombocytopenic purpura does not exhibit a disparity in prevalence between African American and white veterans

Abstract: expression of CXCL13 and CXCR5 in neoplastic T cells, again pointing to a T FH phenotype. [3][4][5][6][7][8] Coexpression of the CXCR5 chemokine receptor and its ligand CXCL13 suggests an autocrine loop, possibly contributing to the survival of neoplastic T cells. All cases demonstrated coexpression of CD154 in the majority of the neoplastic T cells. This antigen plays a crucial role in GC formation 9 and provides survival signals to follicular B cells. 6 Each case showed significant but variable numbers (10%-… Show more

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Cited by 26 publications
(15 citation statements)
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“…This was expected, given the female preponderance in ITP incidence. 17,28 In GPRD, the difference in prevalence between elderly female patients ≥65 years of age administrative data, [19][20][21] whereas cases within the present study were defined by electronic medical records. In addition, earlier data were from the US, whilst these were from the UK.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…This was expected, given the female preponderance in ITP incidence. 17,28 In GPRD, the difference in prevalence between elderly female patients ≥65 years of age administrative data, [19][20][21] whereas cases within the present study were defined by electronic medical records. In addition, earlier data were from the US, whilst these were from the UK.…”
Section: Resultsmentioning
confidence: 99%
“…In published ITP incidence reports, estimates of adult ITP ranged from 1.6-3.9 per 100,000 adults per year in the United States (US), the United Kingdom (UK), and Japan. [13][14][15][16][17][18] Due to the chronic nature of adult ITP 12 and the consequent accumulation of cases in the population, available prevalence estimates are appreciably higher, 12,[19][20][21] ranging from a 1-year prevalence of 9.5 per 100,000 persons 21 to a high of 189.3 per 100,000 persons in a hospital-based study conducted in a US Veterans Administration patient population. 20 …”
Section: Introductionmentioning
confidence: 99%
“…As had been previously reported, the female predominance was largely seen only in middle-aged adults. The prevalence of ITP in African-Americans and white veterans is comparable, suggesting no racial variation [16].…”
Section: Epidemiology In Adult Immune Thrombocytopenic Purpuramentioning
confidence: 96%
“…It is unclear whether it is related to a different genetic background, to protective environmental factors, or to In 2006, a retrospective age-adjusted prevalence study carried out in US nationwide Veteran Affairs hospitals did not found any difference between whites and African Americans. 10 Secondary ITP accounted for 18% of adult cases. This is very close to the experience-based 20% estimate by Cines et al 8 Nevertheless, malignancies (except B-cell chronic lymphocytic leukemia, 2%) were excluded from this latter assessment, whereas they are associated with 10.9% of ITPs in our cohort.…”
Section: Discussionmentioning
confidence: 99%
“…9,10 Apart from ethnic particularities, geographical factors may affect the incidence of autoimmune diseases. 11 The geographical variations of ITP incidence across a wide area has not yet been assessed.…”
Section: Introductionmentioning
confidence: 99%