2013
DOI: 10.1016/j.transproceed.2012.07.161
|View full text |Cite
|
Sign up to set email alerts
|

Immune Tolerance of Skin Allograft Transplantation Induced by Immature Dendritic Cells of a Third Party Carrying Donor Antigens in Mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2015
2015
2021
2021

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 15 publications
0
3
0
Order By: Relevance
“…Emerging evidence suggests that the imDCs usually reside in different tissues and play an important role in transplantation tolerance by inhibiting immune response [10,11]. After skin allograft transplantation, imDCs carrying donor antigens trigger antigen-specific immune tolerance and promote the survival of allogeneic skin grafts [25]. Rapa has recently been confirmed as an immunosuppressant for antirejection due to its suppressive role in T cell activation [14].…”
Section: Discussionmentioning
confidence: 99%
“…Emerging evidence suggests that the imDCs usually reside in different tissues and play an important role in transplantation tolerance by inhibiting immune response [10,11]. After skin allograft transplantation, imDCs carrying donor antigens trigger antigen-specific immune tolerance and promote the survival of allogeneic skin grafts [25]. Rapa has recently been confirmed as an immunosuppressant for antirejection due to its suppressive role in T cell activation [14].…”
Section: Discussionmentioning
confidence: 99%
“…The establishment of donor antigen‐specific tolerance has been shown to enhance skin allograft survival, such as pre‐transplant donor B lymphocytes, induced immature dendritic cells, and bioengineering thymus organoids to restore thymus function . Previous studies have showed that ECDI‐SP treatment holds great potential in inducing graft tolerance and prolonging graft survival, including islet, heart, and kidney in mice or rats .…”
Section: Discussionmentioning
confidence: 99%
“…It is generally believed that immature DCs (imDCs) modulate tolerance, whereas mature DCs facilitate T cell activity and inflammation [5, 6]. Significantly, recent studies have found that imDCs can induce immune tolerance and limit transplant rejection in a variety of organ grafting experiments, including tooth [7], renal [8], corneal [9], and skin allografts [10]; however, these effects were modest and required a large number of cells, stemming from their weak lymph-node homing ability.…”
Section: Introductionmentioning
confidence: 99%