Immunisation schedule of the Spanish Association of Paediatrics: 2016 recommendations

Effectiveness of a Meningococcal Group B Vaccine (4CMenB) in Children

“…Children who started the vaccination series at the age of 24 months or older were deemed to be fully immunized after receipt of the second dose. 2,17 To allow time for the immune response, vaccine doses that were administered within the 14 days preceding the first case date were considered separately. Vaccination status on the first case date was determined for the case patients; for the matched controls, vaccination status on the same calendar day as the first case date of their respective case patient was used.…”

“…13,14 In Spain, the publicly funded immunization schedule included the meningococcal C conjugate vaccine for all children since 2000 and 4CMenB for persons with high-risk conditions for invasive meningococcal disease (i.e., history of meningococcal disease, complement deficiency, eculizumab treatment, anatomical or functional asplenia, and hematopoietic stem-cell transplantation) since 2015. 15 In addition, 4CMenB was available for private purchase, and vaccination of all children 2 months of age or older was recommended by the Spanish Pediatrics Association, 16,17 which resulted in a progressive increase in vaccination coverage. Temporary shortage of 4CMenB might have delayed the vaccination schedule in some children.…”

Vacunación frente a la hepatitisB. Impacto de los programas de vacunación tras 20años de su utilización en España. ¿Es tiempo de cambios?

“…Por su parte, las vacunas combinadas ofrecen, con una sola administración, protección frente a un mayor número de enfermedades, lo que favorece el cumplimiento del calendario de vacunación, y además obtienen una mayor aceptación entre los padres por la disminución del número de pinchazos y la simplificación de la pauta 27,28 . Existen 2 vacunas hexavalentes combinadas comercializas en España (Infanrix Hexa ® y Hexyon ® ), y ambas ofrecen una buena inmunogenicidad, eficacia y tolerabilidad frente a los antígenos que contienen: difteria (D), tétanos (T), tos ferina acelular (Pa), HB, polio inactivada (VPI) y Haemophilus influenzae b (Hib) [29][30][31][32] .…”

“…Los resultados mostraron que aquellos sujetos en los que los valores antes de la dosis de refuerzo eran < 2 mUI/ml, la respuesta a dicha dosis fue inferior que en aquellos con valores superiores. Por tanto, los títu-los de anticuerpos anti-HBs superiores a 2 mUI/ml en los adultos podría ser un nuevo valor predictivo de respuesta a la vacunación de refuerzo y, por tanto, de la existencia de mayor memoria inmunológica 29 .…”

Impact of vaccination uptake on hospitalizations due to rotavirus acute gastroenteritis in 2 different socioeconomic areas of Spain

“…Since 2008, the Advisory Board of Vaccines of Spanish Association of Pediatrics is recommending vaccination against rotavirus in all infants. 22 However, rotavirus vaccine is not included in the national vaccination schedule and it is not financed by the public health system. As a result of this health policy, there are large differences in vaccine coverage in Spain.…”