Immunisering i svangerskapet

Heier, Hans Erik; Berge, Lillian Nordbø; Hervig, Tor; Kiserud, Torvid; Børset, Magne; Eik‐Nes, S. H.; Arsenovic, Mirjana Grujic; Acharya, Ganesh

doi:10.4045/tidsskr.09.0186

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…The use of approved anti‐D immunoglobulin at Mangochi District Hospital could possibly be a cost‐efficient preventive measure [58]. However, sustainable anti‐D prophylaxis programmes remain a challenge for blood transfusion services and clinicians, and may not be feasible at a basic adequate level [59, 60].…”

Section: Discussionmentioning

confidence: 99%

A study of blood transfusion services at a district hospital in Malawi

et al. 2012

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In contrast to the advanced transfusion medicine in developed nations, our findings highlight the persistent and urgent need for life-saving blood transfusions in especially young children and pregnant women in Africa. The results indicate that blood transfusion services adapted to local conditions may be a realistic solution for providing safe blood products in developing countries. Serious challenges, such as HIV transmission and sustainable organization of low-risk blood donations should be addressed to assure access to safe blood products.

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Section: Discussionmentioning

confidence: 99%

A study of blood transfusion services at a district hospital in Malawi

et al. 2012

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Determination of fetal RHD type in plasma of RhD negative pregnant women

Sørensen

Kjeldsen‐Kragh

Husby

et al. 2018

Scandinavian Journal of Clinical and Laboratory Investigation

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Alloimmunization against the RhD antigen is the most common cause of hemolytic disease of the fetus and newborn. Antenatal anti-D prophylaxis in addition to postnatal anti-D prophylaxis reduces the number of RhD-immunizations compared to only postnatal administration. Cell-free fetal DNA released from the apoptotic trophoblastic placental cells into the maternal circulation can be used to determine the fetal RHD type in a blood sample from an RhD negative mother. Based on this typing, antenatal anti-D prophylaxis can be recommended only to RhD negative women carrying an RhD positive fetus, since only these women are at risk of developing anti-D. The objective was to establish and validate a method for non-invasive fetal RHD typing. The fetal RHD genotype was studied in 373 samples from RhD negative pregnant women (median gestational week 24). DNA extracted from plasma was analyzed for the presence/absence of RHD exon 7 and 10 in a real-time PCR. The RHD genotype of the fetus was compared with the serological RhD type of the newborn. In 234 samples, the fetal RHD test was positive and in 127 samples negative. There was one false positive and no false negative results. In 12 samples, the fetal RHD type could not be determined, in all of them due to a maternal RHD gene. This method gives a reliable detection of fetal RHD positivity in plasma from RhD negative pregnant women. Antenatal anti-D prophylaxis based on the predicted fetal RhD type will avoid unnecessary treatment of pregnant women carrying an RhD negative fetus.

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Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities

Tiller

Husebekk

Ahlén

et al. 2017

IJWH

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Differences in platelet type between the fetus and the mother can lead to maternal immunization and destruction of the fetal platelets, a condition named fetal and neonatal alloimmune thrombocytopenia (FNAIT). FNAIT is reported to occur in ~1 per 1,000 live born neonates. The major risk is intracranial hemorrhage in the fetus or newborn, which is associated with severe neurological complications or death. Since no countries have yet implemented a screening program to detect pregnancies at risk, the diagnosis is typically established after the birth of a child with symptoms. Reports on broader clinical impact have increased clinical concern and awareness. Along with new treatment options for FNAIT, the debate around antenatal screening to detect pregnancies at risk of FNAIT has been revitalized.

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Immunisering i svangerskapet

Cited by 4 publications

References 5 publications

A study of blood transfusion services at a district hospital in Malawi

A study of blood transfusion services at a district hospital in Malawi

Determination of fetal RHD type in plasma of RhD negative pregnant women

Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities

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Immunisering i svangerskapet

Cited by 4 publications

References 5 publications

A study of blood transfusion services at a district hospital in Malawi

A study of blood transfusion services at a district hospital in Malawi

Determination of fetal RHD type in plasma of RhD negative pregnant women

Current perspectives on fetal and neonatal alloimmune thrombocytopenia &ndash; increasing clinical concerns and new treatment opportunities

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Current perspectives on fetal and neonatal alloimmune thrombocytopenia – increasing clinical concerns and new treatment opportunities