Immunity and other defenses in pea aphids, Acyrthosiphon pisum

Gerardo, Nicole M.; Altincicek, Boran; Anselme, Caroline; Atamian, Hagop S.; Barribeau, Seth M.; Vos, Marina De; Duncan, Elizabeth J.; Evans, Jay D.; Gabaldón, Toni; Ghanim, Murad; Heddi, Adelaziz; Kaloshian, Isgouhi; Latorre, Amparo; Moya, Andrés; Nakabachi, Atsushi; Parker, Benjamin J.; Pérez-Brocal, Vincente; Pignatelli, Miguel; Rahbé, Yvan; Ramsey, John S.; Spragg, Chelsea; Tamames, Javier; Tamarit, Daniel; Tamborindeguy, Cécilia; Vincent-Monegat, Caroline; Vilcinskas, Andreas

doi:10.1186/gb-2010-11-2-r21

Cited by 395 publications

(520 citation statements)

References 138 publications

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“…Aphids also lack known antimicrobial peptides that control endosymbionts in other insects (Gerardo et al. 2010), which may enable some endosymbionts to increase in abundance under stressful conditions.…”

Section: Introductionmentioning

confidence: 99%

Stress‐induced changes in abundance differ among obligate and facultative endosymbionts of the soybean aphid

Enders

Miller

2016

Ecology and Evolution

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Bacterial endosymbionts can drive evolutionary novelty by conferring adaptive benefits under adverse environmental conditions. Among aphid species there is growing evidence that symbionts influence tolerance to various forms of stress. However, the extent to which stress inflicted on the aphid host has cascading effects on symbiont community dynamics remains poorly understood. Here we simultaneously quantified the effect of host‐plant induced and xenobiotic stress on soybean aphid (Aphis glycines) fitness and relative abundance of its three bacterial symbionts. Exposure to soybean defensive stress (Rag1 gene) and a neurotoxic insecticide (thiamethoxam) substantially reduced aphid composite fitness (survival × reproduction) by 74 ± 10% and 92 ± 2%, respectively, which in turn induced distinctive changes in the endosymbiont microbiota. When challenged by host‐plant defenses a 1.4‐fold reduction in abundance of the obligate symbiont Buchnera was observed across four aphid clonal lines. Among facultative symbionts of Rag1‐stressed aphids, Wolbachia abundance increased twofold and Arsenophonus decreased 1.5‐fold. A similar pattern was observed under xenobiotic stress, with Buchnera and Arsenophonus titers decreasing (1.3‐fold) and Wolbachia increasing (1.5‐fold). Furthermore, variation in aphid virulence to Rag1 was positively correlated with changes in Arsenophonus titers, but not Wolbachia or Buchnera. A single Arsenophonus multi‐locus genotype was found among aphid clonal lines, indicating strain diversity is not primarily responsible for correlated host‐symbiont stress levels. Overall, our results demonstrate the nature of aphid symbioses can significantly affect the outcome of interactions under stress and suggests general changes in the microbiome can occur across multiple stress types.

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Section: Introductionmentioning

confidence: 99%

Stress‐induced changes in abundance differ among obligate and facultative endosymbionts of the soybean aphid

Enders

Miller

2016

Ecology and Evolution

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“…The study identified many D. noxia gut genes, including glutathione s-transferases and carboxypeptidases, involved in insect digestion and detoxification in insects (ffrench Constant et al 2000;Gerardo et al 2010). Glutathione s-transferases are known to detoxify reactive oxygen species related to plant stress in many arthropods (Ramsey et al 2010) whereas carboxypeptidases are basically involved in insect digestion (Bown and Gatehouse, 2004).…”

Section: Discussionmentioning

confidence: 99%

Comparative gut transcriptome analysis reveals differences between virulent and avirulent Russian wheat aphids, Diuraphis noxia

Anathakrishnan¹,

Sinha

Murugan

et al. 2014

Arthropod-Plant Interactions

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“…The recent sequencing of the pea aphid genome revealed an even more reduced immune gene repertoire than honeybees (Gerardo et al, 2010). Pea aphids lack a central immune pathway and all known antibacterial peptides (although they do have a relatively uncommon class of potentially antifungal peptides).…”

Section: Hypothesis-targeted Comparative Sequencingmentioning

confidence: 99%

“…Aphids can harbor several species of intracellular mutualistic bacteria. These mutualists can produce needed amino acids (Douglas, 1998) and can protect their hosts against parasites and other environmental stressors (reviewed in Gerardo et al, 2010). Researchers have hypothesized that aphids may lack these immune components because they are intimately dependent on bacterial symbionts for survival (Gerardo et al, 2010).…”

Section: Hypothesis-targeted Comparative Sequencingmentioning

confidence: 99%

An evolutionarily and ecologically focused strategy for genome sequencing efforts

Barribeau

2011

Heredity

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Immunity and other defenses in pea aphids, Acyrthosiphon pisum

Abstract: The genome of the pea aphid Acyrthosiphon pisum lacks genes thought to be crucial in other insects for recognition, signaling and killing of microbes.

Cited by 395 publications

References 138 publications

Stress‐induced changes in abundance differ among obligate and facultative endosymbionts of the soybean aphid

Stress‐induced changes in abundance differ among obligate and facultative endosymbionts of the soybean aphid

Comparative gut transcriptome analysis reveals differences between virulent and avirulent Russian wheat aphids, Diuraphis noxia

An evolutionarily and ecologically focused strategy for genome sequencing efforts

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