Immunity to Candida albicans.

Rogers, Thomas J.; Balish, Edward

doi:10.1128/mmbr.44.4.660-682.1980

Cited by 133 publications

(57 citation statements)

References 113 publications

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“…Problems involved in studies on the allergy of C. albicans include the ubiquity of this organism and the presence of some immunological responsiveness to it in nearly all individuals [9]. Furthermore, the exact properties of antigens recognized by human IgE antibodies still remain undefined.…”

Section: Introduetionmentioning

confidence: 99%

Allergenic components of Candida albicans identified by immunoblot analysis

Shen

Choo

Tang

et al. 1989

Clin Experimental Allergy

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Allergenic components of Candida albicans fractionated by SDS-polyacrylamide gel electrophoresis (PAGE) and transferred to nitrocellulose membranes were identified using sera from 30 asthmatic patients who showed positive skin test and RAST (radio-allergosorbent test) to C. albicans. The IgE-binding yeast components in the complex antigen preparation were then detected by reaction with enzyme-labelled anti-human IgE antibodies. They were confirmed by Coomassie blue R-250 staining of the membrane to visualize all protein bands after reaction with the enzyme substrate. The IgE-binding patterns of the sera tested were heterogeneous, displaying a total of 16 identifiable components with molecular weights ranging from 20 to 94 kD. A 40 kD component showed the highest IgE-binding frequency, being recognized by 23 (77%) of the 30 sera examined. The other 15 allergenic components identified were recognized by less than 25% of the sera tested. Only two of the 30 serum samples contained IgE antibodies reactive with seven to eight allergenic components. Ten of the 30 sera reacted with only one allergenic component, and the remaining serum samples recognized two to five of the 16 identified allergens. Results described in this study are applicable to allergen standardization work and provide a basis for further study on the role of C. albicans in clinical allergy.

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Section: Introduetionmentioning

confidence: 99%

Allergenic components of Candida albicans identified by immunoblot analysis

Shen

Choo

Tang

et al. 1989

Clin Experimental Allergy

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“…There is general agreement that granulocytes represent the first line of defence against Candida infection (3,13). However, in our hands, normal mice of all strains examined often failed to show a rapid accumulation of inflammatory cells around the invading organisms, even as long as 5 days after infection {Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of systemic human candidiasis occur in debilitated or immunosuppressed patients, so an intact immune system appears to be essential for resistance to infection by this organism. There is substantial clinical evidence implicating cell-mediated rather than humoral immunity as a central element in host defences (1,3,4) and this is reinforced by the observation that 50-70% of Category A AIDS patients, whose T cells have been destroyed by the virus, develop oral thrush (5). Nevertheless, only recently has firm evidence been obtained for the participation of T cells in recovery from primary infection in mice, and for the regulation of host responses by genes within the mouse major histocompatibility complex (MHC) (6.7).…”

Section: Introductionmentioning

confidence: 99%

Murine candidiasis: Strain dependence of host responses after immunization

Ashman

Papadimitriou

1988

Immunol Cell Biol

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Summary After recovery from acute infection with live Candida albicans, both CBA/H and BALB/c mice show increased resistance to colonization by the organism. However, the ‘susceptible’ CBA/H mice develop much stronger protective responses than do ‘resistant’ BALB/c mice. This is manifested particularly as a substantial amelioration of the severity of the lesions in the brain, and a very marked reduction in the number of fungal units therein. Analysis of granulocyte function in normal and immune mice of the two strains tended to exclude this as a basis for the different patterns of susceptibility and resistance.

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“…A 1980 review of the immune response to Candida albicans stressed the need to obtain more basic information on innate host defence mechanisms that control diseases caused by this opportunistic pathogen [1]. There were a number of observations that suggested non-secretion of blood group antigens might be associated with susceptibility to infection by the candida species.…”

Section: Introductionmentioning

confidence: 99%

Non-secretion of blood group antigens and susceptibility to infection by Candida species

Thom

1989

FEMS Microbiology Letters

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Immunity to Candida albicans.

Cited by 133 publications

References 113 publications

Allergenic components of Candida albicans identified by immunoblot analysis

Allergenic components of Candida albicans identified by immunoblot analysis

Murine candidiasis: Strain dependence of host responses after immunization

Non-secretion of blood group antigens and susceptibility to infection by Candida species

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