Immunization of a novel bivalent outer membrane protein simultaneously resisting Aeromonas hydrophila, Edwardsiella anguillarum and Vibrio vulnificus infection in European eels (Angullia angullia)

Guo, Songlin; He, Le; Wu, Liqun; Xiao, Yiqun; Zhai, Shaowei; Yan, Qingpi

doi:10.1016/j.fsi.2019.12.044

Cited by 24 publications

(7 citation statements)

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“…Other outer membrane proteins (Omp)‐based vaccines have been developed, the most used being OmpU, OmpA and OmpII from V. vulnificus , E. anguillarum and A. hydrophila , respectively (Table 5). After vaccination and challenge with a given pathogen, eels vaccinated with Omp generally had significantly higher relative survival than those vaccinated with control solution (Guo et al., 2019, 2020; He et al., 2020; Le et al., 2018; LiHua et al., 2019).…”

Section: Potential Treatmentmentioning

confidence: 99%

Anguilla sp. diseases diagnoses and treatments: The ideal methods at the crossroads of conservation and aquaculture purposes

Parchemin

Tapissier‐Bontemps

Sasal

et al. 2022

Journal of Fish Diseases

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Anguilla anguilla, A. japonica and A. rostrata are the most fished and consumed eel species. However, these species are Critically Endangered, Endangered and Endangered, respectively. A combination of factors is thought to be responsible for their decline including fisheries, climate change, habitat destruction, barriers to migration, pollution and pathogens. Among them, viruses, bacteria and parasites are causing weakening of wild eels and serious economic losses for fishermen and eel farmers. Early detection of pathogens is essential to provide appropriate responses both for conservation reasons and to limit economic losses. Classic diagnosis approaches are time consuming and invasive and usual treatments, for example, antipathogenic substances are becoming obsolete because of pathogen resistance and environmental impact problems. The need for early and non‐invasive diagnostic methods as well as effective and environmentally friendly treatments has increased. Vaccine development and diet supplementation have known a growing interest since their use could allow prevention of diseases. In this review, we summarize the main pathogens—viruses, bacteria and parasites—of the three northern temperate eel species, the methods used to detect these pathogens and the different treatments used. We discussed and highlighted the need for non‐invasive, rapid and efficient detection methods, as well as effective and environmentally friendly treatments for both conservation and aquaculture purposes.

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Section: Potential Treatmentmentioning

confidence: 99%

Anguilla sp. diseases diagnoses and treatments: The ideal methods at the crossroads of conservation and aquaculture purposes

Parchemin

Tapissier‐Bontemps

Sasal

et al. 2022

Journal of Fish Diseases

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“…Vibrio vulnificus, Aeromonas hydrophila, Edwardsiella anguillarum and Vibrio anguillarum. V. vulnificus is mainly located in the gills of the eel and invades the internal organs, resulting in septicaemia (Callol et al, 2013;He, Wu, Ling, et al, 2020); A. hydrophila causes ulcerative disease (Guo et al, 2020;He, Wu, Tang, et al, 2020); E. anguillarum infection results in severe liver injury and abdominal bleeding (Duan et al, 2019;He et al, 2021;Xiao et al, 2020;Zhai et al, 2021), and V. anguillarum and its extracellular product (ECP) cause serious damage to the eel's muscle tissue (Alicia et al, 2005). However, there is no report on V. harveyi infection of cultured freshwater fish so far.…”

Section: The Common Bacterial Pathogens Reported In Eel Farming Includementioning

confidence: 99%

First identification and pathogenicity study of Vibrio harveyi isolated from diseased American eel ( Anguilla rostrata ) cultivated in freshwater

Wan

Yang

et al. 2021

Aquaculture Research

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Vibrio harveyi is ubiquitous in warm seawater and sediments and has become a common bacterial pathogen isolated from aquatic animals and even humans (Brehm et al., 2020;Joana et al., 2019;Peeralil et al., 2020). It is also a member of intestinal microflora in the intestines of marine vertebrates and invertebrates (Rungrassamee et al., 2016). Vibrio harveyi mainly infects shrimp (Martin et al., 2004;Zhou et al., 2012) and causes intestinal tract (Rungrassamee et al., 2016) and hepatopancreatic necrosis (Sarmila et al., 2019). Under natural conditions, fish are generally more susceptible to V. harveyi than invertebrates (Owens & Busico-Salcedo, 2006). Vibrio harveyi generally infect commercially important fish such as orange-spotted grouper (Epinephelus coioides) (Bai et al., 2020) and Atlantic salmon (Salmo salar) (Zhang & Austin, 2000). It also causes muscular ulcer, tail erosion, eye infection, symptoms of tongue sole (Cynoglossus semilaevis) and gilthead bream (Sparus aurata) (Haldar et al., 2010;Li et al., 2019), and 'Scale Drop and Muscle Necrosis disease' (SDMND)

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“…In recent years, recombinant OMPs are widely tested as subunit vaccines for various pathogens in different fish species since they are highly immunogenic and they are considered safe because they only contain the antigen proteins and not the entire pathogen ( 59 , 65 , 71 , 77 – 80 , 90 – 105 ). Subunit vaccines either (i) are made of specific targeted epitopes identified from total OMPs using technologies such in silico analysis or mass spectrometry ( Table 2 ) or (ii) use total OMP expressed in recombinant expression vectors ( Table 3 ).…”

Section: Recombinant Antigen Delivery System For Outer Membrane Protementioning

confidence: 99%

Application of Outer Membrane Protein-Based Vaccines Against Major Bacterial Fish Pathogens in India

et al. 2020

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Aquaculture is one of the fastest-growing food-producing sectors in the world. However, its growth is hampered by various disease problems due to infectious microorganisms, including Gram-negative bacteria in finfish aquaculture. Disease control in aquaculture by use of antibiotics is not recommended as it leads to antibiotic residues in the final product, selection, and spread of antibiotic resistance in the environment. Therefore, focus is on disease prevention by vaccination. All Gram-negative bacteria possess surface-associated outer membrane proteins (OMPs), some of which have long been recognized as potential vaccine candidates. OMPs are essential for maintaining the integrity and selective permeability of the bacterial membrane and play a key role in adaptive responses of bacteria such as solute and ion uptake, iron acquisition, antimicrobial resistance, serum resistance, and bile salt resistance and some adhesins have virulence attributes. Antigenic diversity among bacterial strains even within the same bacterial species has constrained vaccine developments, but OMPs that are conserved across serotypes could be used as potential candidates in vaccine development, and several studies have demonstrated their efficacy and potential as vaccine candidates. In this review, we will look into the application of OMPs for the design of vaccines based on recombinant proteins, subunit vaccines, chimeric proteins, and DNA vaccines as new-generation vaccine candidates for major bacterial pathogens of fish for sustainable aquaculture.

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Immunization of a novel bivalent outer membrane protein simultaneously resisting Aeromonas hydrophila, Edwardsiella anguillarum and Vibrio vulnificus infection in European eels (Angullia angullia)

Cited by 24 publications

References 50 publications

Anguilla sp. diseases diagnoses and treatments: The ideal methods at the crossroads of conservation and aquaculture purposes

Anguilla sp. diseases diagnoses and treatments: The ideal methods at the crossroads of conservation and aquaculture purposes

First identification and pathogenicity study of Vibrio harveyi isolated from diseased American eel ( Anguilla rostrata ) cultivated in freshwater

Application of Outer Membrane Protein-Based Vaccines Against Major Bacterial Fish Pathogens in India

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