Immuno-assay of Human Chorionic Gonadotropin in Normal and Pathologic Pregnancy

Brody, Samuel D.; Carlström, Gun

doi:10.1210/jcem-22-6-564

Cited by 61 publications

(19 citation statements)

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“…The similar findings of Brody and Carlstr6m, derived from studies of pathologic pregnancies by an immunologic assay for human chorionic gonadotropin, have been recently published (45).…”

Section: Acknowledgm Entsupporting

confidence: 76%

Evaluation of Vaginal Smear, Serum Gonadotropin, Protein-Bound Iodine, and Thyroxine-Binding as Measures of Placental Adequacy*

Nicoloff¹,

Nicoloff²,

Dowling³

1962

J. Clin. Invest.

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During pregnancy the characteristic increase in the thyroxine-binding capacity of the circulating globulin, TBG (1-3), is associated with a retarded rate of thyroxine turnover (4) and an increase in the concentration of hormonal iodine (PBI) in the plasma (1-4). These alterations in iodine metabolism have not been found in women with choriocarcinomas who excrete large quantities of chorionic gonadotropin (5), but do occur in nonpregnant individuals given large quantities of estrogens (6-8). It has been concluded, therefore, that during pregnancy these phenomena result from systemic effects of placental estrogens. Moreover, the sera of aborting women often fail to show the characteristic increase in serum PBI (9) and in thyroxine-binding by TBG (2).In the past, attempts have been made to use the concentration of PBI as an indicator of fetal viability (9, 10); however, as appears to be true of studies of urinary or plasma chorionic gonadotropin determinations, pregnandiol and estrogen levels, and vaginal smears (11-15), the PBI has not proved satisfactory for routine use. It appeared possible, however, that assessment of TBG might prove of value as an indicator of placental function. For that reason a technique was developed for rapidly estimating serum thyroxinebinding, and its value in predicting the outcome *

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“…The similar findings of Brody and Carlstr6m, derived from studies of pathologic pregnancies by an immunologic assay for human chorionic gonadotropin, have been recently published (45).…”

Section: Acknowledgm Entsupporting

confidence: 76%

Evaluation of Vaginal Smear, Serum Gonadotropin, Protein-Bound Iodine, and Thyroxine-Binding as Measures of Placental Adequacy*

Nicoloff¹,

Nicoloff²,

Dowling³

1962

J. Clin. Invest.

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show abstract

“…The number of contaminants shown to be present has been variable, depending on the preparations and characterization techniques used. Adsorption methods using serum or urine have been employed to increase the HCG specificity of the antiserum (1,3,6). A previous study from this laboratory questioned the validity of adsorption and the specificity of the antiserum after adsorption (7).…”

Section: Discussionmentioning

confidence: 99%

“…Immunological methods have been used to measure human chorionic gonadotropin (HCG) in normal and pathological pregnancies (1)(2)(3). Immunohistological methods with the fluorescent antibody technique have also been used to localize HCG in placenta and tumors (4,5).…”

mentioning

confidence: 99%

“…The antisera used in the above studies were produced with HCG preparations that contained contaminants and, therefore, contained antibodies to a multiplicity of extraneous antigens in addition to HCG. Antibodies to some contaminants can be removed from HCG antisera by adsorption with urine, serum, or their extracts (1,3,6). Previous studies, however, have demonstrated that absorption methods probably do not make such antisera HCG specific (7).…”

mentioning

confidence: 99%

“…Previous studies, however, have demonstrated that absorption methods probably do not make such antisera HCG specific (7). This investigation is concerned with the immunological characteristics of several commercial HCG preparations in an attempt to evaluate the reliability and validity of the HCG antisera previously employed (1)(2)(3)(4)(5).…”

mentioning

confidence: 99%

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