Immuno-inflammatory responses in the tissue adjacent to titanium miniplates used in the treatment of mandibular fractures

Katou, Fuminori; Andoh, Noriaki; Motegi, Katsutoshi; Nagura, Hideaki

doi:10.1016/s1010-5182(96)80049-7

Cited by 102 publications

(61 citation statements)

References 36 publications

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“…However, as mentioned above, no metal or alloy is completely inert in vivo. In this regard, some authors claim that titanium miniplates should be removed to allow for physiologic bony adaptation and avoidance of a foreign body reaction (Ferguson, 1960;Katou et al, 1996;Moran et al, 1991;Rosenberg et al, 1993;Young-Kyun et al, 1997).…”

Section: Tissue Response At the Metal-tissue Interfacementioning

confidence: 99%

Systemic and Local Tissue Response to Titanium Corrosion

Olmedo¹,

Tasat²,

Duffó³

et al. 2012

Pitting Corrosion

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Section: Tissue Response At the Metal-tissue Interfacementioning

confidence: 99%

Systemic and Local Tissue Response to Titanium Corrosion

Olmedo¹,

Tasat²,

Duffó³

et al. 2012

Pitting Corrosion

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“…8,21,22) Ryhänen et al found no qualitative differences in histology between stainless steel, Ti-6Al-4V, and Ti-Ni alloy 26 weeks after implantation in rats. 8) Macrophages are the main inflammatory cell types in a short-term implantation.…”

Section: Discussionmentioning

confidence: 99%

“…20) The appearance of increased wear debris from Ti has been associated with inflammation, bone resorption, and pain. 18,19,[21][22][23][24] To improve mechanical strength and wear resistance, various elements have been added to create new Ti alloys. Ti-6Al-4V alloy is a high-strength Ti alloy, but its biocompatibility is considered lower than that of commercially pure Ti.…”

Section: Introductionmentioning

confidence: 99%

Improved Biocompatibility of Titanium–Zirconium (Ti–Zr) Alloy: Tissue Reaction and Sensitization to Ti–Zr Alloy Compared with Pure Ti and Zr in Rat Implantation Study

Ikarashi¹,

Toyoda

Kobayashi

et al. 2005

Mater. Trans.

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Titanium-zirconium (Ti-Zr) binary alloy has better corrosion resistance and mechanical properties than commercially pure Ti. The present study was designed to determine the biocompatibility of Ti-Zr alloy by an implantation test in animal bodies in comparison with pure Ti, Zr, and chromium (Cr) implants as positive controls. Sample specimens were placed in a subcutaneous position in rats for 8 months. No significant decreases in body weight, the weight of any organ, or the weight of any organ relative to body weight were found in the implant groups compared to a no-implant control group. On hematological examination, small differences in several parameters were found in some groups, but these changes were not attributable to the materials implanted. Mitogen-induced blastogenesis was observed in similar degrees among all implant groups. These results suggest that the implantation of test samples did not cause systemic toxicity or a decrease in immune activity. The fibrous capsule membranes around the Ti and Ti-Zr alloy implants were thinner than those around Cr implants. The numbers of macrophages, inflammatory cells, and other cells involved in immune responses in and around the fibrous capsules of the Cr-and Ti-implant groups were higher than those of the Ti-Zr alloy-and Zr-implant groups. The Ti-Zr alloy had the lowest total score of tissue responses among the materials tested. None of the animals from the Ti-, Zr-, and Ti-Zr alloy-implant groups exhibited a skin reaction following exposure to Ti or Zr salt solutions. These results indicate the Ti-Zr alloy has better biocompatibility than Ti for use as an artificial surgical implant.

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“…Data are averages of ten or fifteen experiments with tan-dard deviation of less than 10% -30%. s hypersensitivity in the vicinity of titanium based on observation of CD-4-and CD-8-positive T-lymphocytes [18,19]. Smith et al [20] reported metal ions (titanium, aluminum, vanadium) in the blood of patients following insertion of titanium alloy (Ti-6Al-4V) implants.…”

Section: Discussionmentioning

confidence: 99%

Plasma cytokine profiles following subcutaneous implantation of titanium in mice

Oda¹,

Sasaki²,

Ito³

et al. 2013

JBiSE

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Aims and Objectives: The purpose of this study was to investigate the influence of a titanium implant on immune response in mouse by monitoring change in plasma cytokine profiles. Materials and Methods: C57BL/6 (type 1 T helper cell-predominant) and BALB/c (type 2 T helper cell-predominant) mice were used. Each type was divided into an experimental and a control group: in the former, pure titanium implants (Φ 1 mm × 1 mm) were inserted into the back of the mice subcutaneously; in the latter, the wound was sutured closed with no insertion of an implant. Blood samples were collected before implantation and at 3 hr, 24 hr, 3 d, 1 mo, and 3 mo after implantation. Levels of IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17A, IL-23, IFN-γ, TNF-α, and TGF-β1 were measured by multi-analyte enzyme-linked immunosorbent assay. Results: Baseline cytokine levels were generally higher in the BALB/c mice than in their C57BL/6 counterparts. Cytokine levels showed only slight variation after implantation of titanium in either strain. No statistically significant differences in cytokine levels were detected, except for those of IL-6 and IL-10. Conclusion: The results showed that titanium implantation induced no clear Th1-, Th2-, or Th17-mediated immune response in either Th1-or Th2-predominant mice.

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Immuno-inflammatory responses in the tissue adjacent to titanium miniplates used in the treatment of mandibular fractures

Cited by 102 publications

References 36 publications

Systemic and Local Tissue Response to Titanium Corrosion

Systemic and Local Tissue Response to Titanium Corrosion

Improved Biocompatibility of Titanium–Zirconium (Ti–Zr) Alloy: Tissue Reaction and Sensitization to Ti–Zr Alloy Compared with Pure Ti and Zr in Rat Implantation Study

Plasma cytokine profiles following subcutaneous implantation of titanium in mice

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Immuno-inflammatory responses in the tissue adjacent to titanium miniplates used in the treatment of mandibular fractures

Cited by 102 publications

References 36 publications

Systemic and Local Tissue Response to Titanium Corrosion

Systemic and Local Tissue Response to Titanium Corrosion

Improved Biocompatibility of Titanium&ndash;Zirconium (Ti&ndash;Zr) Alloy: Tissue Reaction and Sensitization to Ti&ndash;Zr Alloy Compared with Pure Ti and Zr in Rat Implantation Study

Plasma cytokine profiles following subcutaneous implantation of titanium in mice

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Improved Biocompatibility of Titanium–Zirconium (Ti–Zr) Alloy: Tissue Reaction and Sensitization to Ti–Zr Alloy Compared with Pure Ti and Zr in Rat Implantation Study