Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages

Rosa, Michelino Di; Malaguarnera, Giulia; Gregorio, Corinne De; Palumbo, Maria Concetta; Nunnari, Giuseppe; Malaguarnera, Mariano

doi:10.1016/j.cellimm.2012.10.009

Cited by 137 publications

(102 citation statements)

References 35 publications

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“…Crucially, calcitriol has long been shown to possess immune-regulatory properties and may inhibit key steps in this inflammatory process. [31][32][33] In present study 25-hyroxyvitamin D level is significantly lower in patient group compared with control group (18.2±10.9 vs 28.8±21ng/mL). Vitamin D deficiency was present in 81.4% patient in case group whereas 57.7% in control group.…”

Section: Resultssupporting

confidence: 43%

A study of association of vitamin D deficiency and coronary artery disease

Kumar

Verma

et al. 2017

Int J Res Med Sci

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Background: Recently vitamin D has received great interests for its multiple effects on inflammatory system and potential role in atherothrombosis. Coronary artery disease (CAD) is one of the common causes of death and disability in developed countries. Experimental evidence points to the involvement of multiple factors in coronary plaque formation, including vitamin D. The study aimed to examine the association of coronary artery disease with vitamin D level.Methods: 140 patients of CAD (coronary artery disease) and 101 age and sex matched control were enrolled in the study and 25-hyroxyvitamin D (25(OH)D) concentration was measured. All participants were evaluated for presence of conventional risk factors for coronary artery disease. Association of vitamin D level was established after adjusting other risk factors using logistic regression analysis.Results: In our study vitamin D level is significantly lower in patient group (CAD patients) compared with control group (18.2±10.9 vs 28.8±21ng/mL). Vitamin D deficiency was present in 81.4% patient in CAD patients whereas 57.7% in control group. Vitamin D deficiency was found to be an independent predictor of CAD after adjusting effect of other risk factors like hypertension, diabetes, smoking, obesity, high blood cholesterol and level of physical activity with adjusted odds ratio (95% confidence interval) 2.695 (1.148-6.330).Conclusions: In present study patients of coronary artery disease had significantly low level of vitamin D as compared to individual without coronary artery disease. Vitamin D deficiency was found to be an independent predictor of CAD after adjusting other risk factors emphasizing that vitamin D can be a potential risk factor for development of coronary artery disease.

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Section: Resultssupporting

confidence: 43%

A study of association of vitamin D deficiency and coronary artery disease

Kumar

Verma

et al. 2017

Int J Res Med Sci

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“…Di Rosa M et al found that 1,25-dihydroxyvitamin-D(3) influences macrophages chemotaxis and differently modulates the expression of Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and TLRs in the two different stages of monocytes/macrophage maturation [56]. Campbell GR et al report that TLR8 activation in human macrophages induces the expression of the human cathelicidin microbial peptide (CAMP), the VDR and cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27b1), which 1α-hydroxylates the inactive form of vitamin D, 25-hydroxycholecalciferol, into its biologically active metabolite.…”

Section: Vitamin D and Inflammationmentioning

confidence: 99%

New Insights on the Role of Vitamin D in the Progression of Renal Damage

Lucisano

Buemi

Passantino

et al. 2013

Kidney Blood Press Res

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Several studies indicate a relationship between hypovitaminosis D, survival, vascular calcification and inflammation. In addition to its central role in the regulation of bone mineral metabolism, vitamin D also contributes to other systems, including the immune, cardiovascular and endocrine systems. Vitamin D analogs reduces proteinuria, in particular through suppression of the renin-angiotensin-aldosterone system (RAAS) and exerts anti-inflammatory and immunomodulatory effects. In particular vitamin D deficiency contribute to an inappropriately activated RAAS, as a mechanism for progression of chronic kidney disease (CKD) and/or cardiovascular disease. Human and sperimental models of CKD showed that vitamin D may interact with B and T lymphocytes and influence the phenotype and function of the antigen presenting cells and dendritic cells, promoting properties that favor the induction of tolerogenic T regulators rather than T effectory. Interstitial fibrosis may be prevented through vitamin D supplementation. Renal myofibroblast, an activated fibroblast with expression of a molecular hallmark α-smooth muscle actin (α-SMA), is generally considered the principal matrix-producing effector cells that are responsible for the excess production of extracellular matrix (ECM) components in the fibrotic tissues. It turns out that calcitriol effectively blocks myofibroblast activation from interstitial fibroblasts, as evidenced by suppression of TGF-β1-mediated α-SMA expression.

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“…The mechanism behind the down-regulation of pro-inflammatory cytokine expression by 1,25D3 is suggested to involve a VDR-associated reduction of pattern recognition receptor TLR2, TLR4, dectin-1 and mannose receptor expression [27]. Lipopolysaccharide-stimulated production of IL-1β, IL-6 and TNFα is suppressed by 1,25D3 in human and murine monocytes/macrophages [28][29][30]. Interestingly, the down-regulation of pro-inflammatory cytokines upon stimulation with 1,25D3 seems to vary with the stage of monocyte/macrophage maturation, and, moreover, this effect seems to be dependent on MAPK phosphatase-1 [29,30].…”

Section: 25d3 Differentially Attenuates Cytokine/chemokine Productimentioning

confidence: 99%

“…Lipopolysaccharide-stimulated production of IL-1β, IL-6 and TNFα is suppressed by 1,25D3 in human and murine monocytes/macrophages [28][29][30]. Interestingly, the down-regulation of pro-inflammatory cytokines upon stimulation with 1,25D3 seems to vary with the stage of monocyte/macrophage maturation, and, moreover, this effect seems to be dependent on MAPK phosphatase-1 [29,30]. Importantly, 1,25D3 enhances glucocorticoid-induced inhibition of lipolysaccharide-stimulated IL-6 in human monocytes, suggesting that 1,25D3 and glucocorticoids may act in synergy [31].…”

Section: 25d3 Differentially Attenuates Cytokine/chemokine Productimentioning

confidence: 99%

Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production

2015

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The steroid hormone metabolite of vitamin D 3 , 1α,25-dihydroxyvitamin D 3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/proinflammatory attacks. Low serum levels of vitamin D 3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system. Experimental studies in various experimental systems show that 1,25D3 differentially regulates the production of pro-inflammatory cytokines and chemokines depending on cell type. Importantly, many reports show that 1,25D3 up-regulates expression of the human antimicrobial peptide hCAP-18/LL-37 gene. The hCAP-18/LL-37 gene seems indeed to be an important transcriptional target for 1,25D3. However, only weak evidence is presented showing that 1,25D3 consistently increases the amount of biologically active LL-37 peptide.In the present review, we discuss 1,25D3-induced down-regulation of cytokine/chemokine production and stimulation of hCAP-18/LL-37 gene expression which represent two very important pathways for 1,25D3-evoked regulation of the innate immune response.

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Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages

Cited by 137 publications

References 35 publications

A study of association of vitamin D deficiency and coronary artery disease

A study of association of vitamin D deficiency and coronary artery disease

New Insights on the Role of Vitamin D in the Progression of Renal Damage

Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production

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