2016
DOI: 10.1007/s00011-016-0957-7
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Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation

Abstract: This work demonstrates the reduction of TLR3-mediated intestinal tissue injury by immunobiotic lactobacilli through the modulation of intraepithelial lymphocytes response. It is a step forward in the understanding of the cellular mechanisms involved in the antiviral capabilities of immunobiotic strains.

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Cited by 37 publications
(65 citation statements)
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“…Recently, we confirmed in vivo the differential antiviral immunomodulatory activities triggered by L. rhamnosus CRL1505 and L. plantarum CRL1506 (65). Both strains increased the production of IFNs, the CRL1505 treatment being the most effective for increasing the levels of IFN-γ.…”
Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionssupporting
confidence: 56%
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“…Recently, we confirmed in vivo the differential antiviral immunomodulatory activities triggered by L. rhamnosus CRL1505 and L. plantarum CRL1506 (65). Both strains increased the production of IFNs, the CRL1505 treatment being the most effective for increasing the levels of IFN-γ.…”
Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionssupporting
confidence: 56%
“…Therefore, TLR3 signaling stimulates IECs to express IL-15 and RAE1 and induces CD3 + NK1.1 + CD8αα + IELs to express NKG2D through IEC-derived IL-15. In our hands, poly(I:C) treatment of mice increased intestinal injury in a IL-15- and CD8αα + NKG2D + -dependent manner (65). Poly(I:C) induced inflammatory-mediated intestinal tissue damage through the increase of CD3 + NK1.1 + and CD8αα + NKG2D + cells as well as proinflammatory mediators (TNF-α, IL-1β, IFN-γ, IL-15, RAE1, IL-8).…”
Section: Cellular and Molecular Mechanisms Of Immunobiotics Actionsmentioning
confidence: 77%
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“…Exposure to two different strains of Lactobacillus reduced epithelial expression of IL-15 and the NKG2D ligand Rae1 (retinoic acid early inducible-1) to alleviate TLR3-mediated increases in CD8αα IEL number and NKG2D expression. [61] Further, prophylactic administration of a probiotic mixture containing Lactobacillus acidophilus and Bifidobacterium longum conferred protection against TNBS colitis, which was associated with reduced CD4 + T cells and increased γδ T cells in the intraepithelial compartment. Interestingly, the inverse distribution of these cells was observed in the lamina propria in response to TNBS in probiotic-treated mice.…”
Section: Commensal Bacteria Influence Iel Development and Functionmentioning
confidence: 99%