Immunocastration of goats using anti-gonadotrophin releasing hormone vaccine

Lents, Maicon Pereira; Barbosa, Larissa Pires; Santana, Ana Lúcia Almeida; Pinheiro, Emmanuel Emydio Gomes; Mugabe, Lopes César; Biscarde, Carmo Emanuel Almeida; Kiya, Cláudia Kazumi; Machado, William Morais; Souza, Rosiléia Silva

doi:10.1016/j.theriogenology.2018.03.013

Cited by 23 publications

(16 citation statements)

References 23 publications

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“…The successful development and use of vaccines has saved thousands of lives and large amounts of money. In the future, vaccines have the potential to be used not only against infectious diseases but also for cancer as a prophylactic and treatment tool, and for elimination of allergens (1–3). Prior to the 1980s, vaccines were developed for protection against disease-causing microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Advances in mRNA Vaccines for Infectious Diseases

et al. 2019

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During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.

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Section: Introductionmentioning

confidence: 99%

Advances in mRNA Vaccines for Infectious Diseases

et al. 2019

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“…Thus, the larger the diameter of the seminiferous tubules, the smaller the LST value. The goats in G1 and G2 showed values higher than those of the crossbred goats studied by Lents et al (2018), which presented LST of 1,769.48 m and LGT of 13.06 m/g. This difference occurred because of the greater tubular diameter and volume values used to obtain these results.…”

Section: Discussionmentioning

confidence: 65%

Testicular and seminal evaluation of goats fed hay Cenostigma pyramidale

et al. 2020

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This study aimed to assess the possible occurrence of reproductive changes in male goats associated with ingestion of Cenostigma pyramidale hay. Sixteen animals divided into two experimental groups, G1 and G2 (control group) were used. Animals in G1 received 2% of forage, based on live weight (LW), composed of 100% of C. pyramidale, and animals in G2 received 2% of Panicum maximum “Massai’ grass hay, based on LW. Both groups received 1% of concentrated feed supplementation based on LW, along with mineralized salt and water ad libitum. The goats were subjected to weighing, testicular biometry, and semen and blood collection every 30 days. After 120 days, the animals were castrated and their testes were collected. Testicular measurements were performed and fragments were collected for histological processing to determine the gonadosomatic index (GSI), diameter of the seminiferous tubules, height of the germinal epithelium (HGE), volumetric proportion and volume of the testicular parenchyma components, total length of the seminiferous tubules, length of the seminiferous tubules per gram of testis, and leydigosomatic and tubulosomatic indexes. The data were evaluated for normality using the Student’s t-test. Data with normal distribution were assessed using analysis of variance (ANOVA) and the non-parametric data were evaluated using the Kruskal-Wallis test, both at 5% probability. Statistically significant differences (p<0.05) were observed for GSI (G1=0.48 ±0.08 and G2=0.34 ±0.09) and HGE (G1=52.95 ±2.99 and G2=.47.63 ±2.67) between treatments. Consumption of C. pyramidale hay increased LW and, consequently, testicular weight, contributing to high GSI. In conclusion, ingestion of C. pyramidale has no toxic effect on the testicular, seminal and histological parameters of goat testis. Due to its nutritional characteristics, consumption of this plant improves animal body development. Because C. pyramidale is adapted to semi-arid regions, it can be an alternative source of feed for goats during periods of shortage.

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“…Immunological castration is commercially available for cattle and swine. A recent study demonstrated that the vaccine used to castrate cattle is also effective in goats (LENTS et al, 2018). Most studies on immunological castration investigated the effects of this method on fertility, zootechnical performance, and carcass characteristics.…”

Section: Methods To Sterilize Male Animalsmentioning

confidence: 99%

Systemic inflammatory and stress markers in cattle and sheep submitted to different reproductive procedures

et al. 2018

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Previous studies have evaluated the effects of different reproductive procedures on discomfort markers in sheep and cattle. Such studies may help stimulate the adoption of techniques that are more beneficial for animal welfare. However, markers that are commonly used to evaluate discomfort are highly influenced by external factors. To overcome this, several systemic markers can be evaluated to more precisely identify stress, pain, and inflammation. Such markers include cortisol, acute phase proteins, bradykinin, and substance P. We aimed to review the potential markers of stress, pain, and inflammation, and discuss how and when they are regulated after different stimuli related to reproductive procedures in cattle and sheep. Furthermore, we aimed to review how reproductive procedures with different degrees of invasiveness cause stress and provide information that may help develop strategies to limit animal discomfort.

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Immunocastration of goats using anti-gonadotrophin releasing hormone vaccine

Cited by 23 publications

References 23 publications

Advances in mRNA Vaccines for Infectious Diseases

Advances in mRNA Vaccines for Infectious Diseases

Testicular and seminal evaluation of goats fed hay Cenostigma pyramidale

Systemic inflammatory and stress markers in cattle and sheep submitted to different reproductive procedures

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