Immunochemical Identification of Melanocortin and Leptin Receptors on Serotoninergic Neurons in the Rat Midbrain

Романова, И. В.; Mikhailova, Elena V.; Шпаков, А. О.

doi:10.1007/s11055-019-00809-w

Cited by 3 publications

(2 citation statements)

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“…6,11 Leptin-mediated regulation of appetite and energy expenditure takes place by inhibiting 5-HT synthesis and release in the brain stem neurons. 12,13 The study was designed to determine which feeding schedule can produce behavioral, hormonal, and serotonergic deficits in rats. We assessed 2 rat models of food restriction to determine the effects of diet restriction, particularly on, hyperactivity, circulating leptin and corticosterone, and 5-HT metabolism in the striatum.…”

Section: Introductionmentioning

confidence: 99%

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Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats

Saeed

Mahmood

Ali

et al. 2022

Int J�Tryptophan�Res

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To determine the effect of long-term restricted feeding schedules on behavior, serotonergic responses, and neuro-endocrine functions, metabolism of serotonin (5-HT) in the striatum, expression of serotonin-1A (5-HT1A) auto-receptor in the raphe nuclei and circulating levels of leptin and corticosterone were determined in female Wistar rats kept on excessive food restriction schedule. Due to a role of dietary deficiency of tryptophan (Trp) in influencing serotonergic neurotransmission, circulating levels of Trp were also determined. Estimations were done in 2 different restricted feeding models: time-restricted feeding (TRF) and diet restricted (DR). TRF animals were given access to food ad libitum only for 2 hours/day. The DR animals were given a small calculated amount of food each day. We found that chronic food restriction for 5 weeks cause a significant decrease in the body weight and produced hyperactivity in both, TRF and DR animals. Levels of Trp were declined in circulation and in the striatum. Similarly, the levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were decreased in the striatum. Also, the expression of 5-HT1A auto-receptor was declined in the raphe nuclei. These changes in 5-HT metabolism and 5-HT1A auto-receptor expression were more profound in DR animals as compare to TRF animals. Similarly, hypoleptinemia and increased corticosterone found in both models was higher in DR animals. Effect of dietary deficiency of Trp in the modulation of striatal 5-HT metabolism and its consequences on circulating leptin and corticosterone are discussed.

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Section: Introductionmentioning

confidence: 99%

“…6,11 Leptin-mediated regulation of appetite and energy expenditure takes place by inhibiting 5-HT synthesis and release in the brain stem neurons. 12,13…”

Section: Introductionmentioning

confidence: 99%