Immunocytochemical and Ultrastructural Evidence Supporting That Andes Hantavirus (ANDV) Is Transmitted Person-to-Person Through the Respiratory and/or Salivary Pathways

Pizarro, E.; Mendez, C. A.; Zaror, Luis; Mansilla, Carlos; Tapia, Mauricio; Carrasco, Cristián; Salazar, Paula; Murúa, Roberto; Padula, Paula; Otth, Carola; Rodríguez, Estéban M.

doi:10.3389/fmicb.2019.02992

Cited by 17 publications

(17 citation statements)

References 50 publications

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“…Despite the severity of these diseases, no efficient treatment is available. Inhalation of aerosols contaminated with infected rodent excreta is the major route of transmission, although person-to-person transmission of a pulmonary syndrome caused by Andes hantavirus (ANDV) has also been reported (Martinez et al, 2005;Padula et al, 1998;Pizarro et al, 2019). NWHs therefore have the potential to adapt to humanto-human air-borne transmission routes, increasing their epidemic potential.…”

Section: Introductionmentioning

confidence: 99%

The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism

Serris

Stass

Bignon

et al. 2020

Cell

123

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Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for which no treatment is available. The hantavirus particles are pleomorphic and display a characteristic square surface lattice. The envelope glycoproteins Gn and Gc form heterodimers that further associate into tetrameric spikes, the lattice building blocks. The glycoproteins, which are the sole targets of neutralizing antibodies, drive virus entry via receptor-mediated endocytosis and endosomal membrane fusion. Here we describe the high-resolution X-ray structures of the heterodimer of Gc and the Gn head, and of the homotetrameric Gn base. Docking them into an 11.4 Å resolution cryo-electron tomography map of the hantavirus surface accounted for the complete extramembrane portion of the viral glycoprotein shell and provided unprecedented detail on the surface organization of these pleomorphic virions. Our results, which further revealed an in-built mechanism controlling Gc membrane-insertion for fusion, pave the way for immunogen design to protect against pathogenic hantaviruses Man scrip

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Section: Introductionmentioning

confidence: 99%

The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism

Serris

Stass

Bignon

et al. 2020

Cell

123

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“…Other hantavirus species, such as the Sin Nombre virus (SNV) and Andes virus (ANDV), that are prevalent in North and South America, respectively, can cause human hantavirus cardiopulmonary syndrome (HCPS) 8,9 . In addition, ANDV is known to be transmitted from person to person through the respiratory tract and saliva 10 . Infection with these viruses may cause various clinical presentations, from asymptomatic to acute fever and hemorrhage, acute kidney or lung injury, and even hypotensive shock 11 .…”

mentioning

confidence: 99%

HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients

Liu

et al. 2021

Commun Biol

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Hantaan viruses (HTNVs) are zoonotic pathogens transmitted mainly by rodents and capable of infecting humans. Increasing knowledge of the human response to HTNV infection can guide the development of new preventative vaccines and therapeutic strategies. Here, we show that HTNV can infect CD8+ T cells in vivo in patients diagnosed with hemorrhagic fever with renal syndrome (HFRS). Electron microscopy-mediated tracking of the life cycle and ultrastructure of HTNV-infected CD8+ T cells in vitro showed an association between notable increases in cytoplasmic multivesicular bodies and virus production. Notably, based on a clinical cohort of 280 patients, we found that circulating HTNV-infected CD8+ T cell numbers in blood were proportional to disease severity. These results demonstrate that viral infected CD8+ T cells may be used as an adjunct marker for monitoring HFRS disease progression and that modulating T cell functions may be explored for new treatment strategies.

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“…The presence of ANDV in the alveolar epithelium and salivary glands of Sigmondontine rodents reinforces intraspecies transmission from saliva and biting (Padula et al, 2004). ANDV infected patients have shown the virus to be present in pneumocytes and pulmonary macrophages, with ultrastructural and immunocytochemical studies revealing viral replication occurring in the alveolar epithelial cells with virus-like particles being released into the alveolar lumen (Pizarro et al, 2019). ANDV is likely secreted into human saliva and transmitted through close, intimate encounters or by exposure to respiratory droplets released through coughing or sneezing.…”

Section: Transmissionmentioning

confidence: 74%

Biodefense Implications of New-World Hantaviruses

D’Souza

Patel

2020

Front. Bioeng. Biotechnol.

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Hantaviruses, part of the Bunyaviridae family, are a genus of negative-sense, single-stranded RNA viruses that cause two major diseases: New-World Hantavirus Cardiopulmonary Syndrome and Old-World Hemorrhagic Fever with Renal Syndrome. Hantaviruses generally are found worldwide with each disease corresponding to their respective hemispheres. New-World Hantaviruses spread by specific rodent-host reservoirs and are categorized as emerging viruses that pose a threat to global health and security due to their high mortality rate and ease of transmission. Incidentally, reports of Hantavirus categorization as a bioweapon are often contradicted as both US National Institute of Allergy and Infectious Diseases and the Centers for Disease Control and Prevention refer to them as Category A and C bioagents respectively, each retaining qualitative levels of importance and severity. Concerns of Hantavirus being engineered into a novel bioagent has been thwarted by Hantaviruses being difficult to culture, isolate, and purify limiting its ability to be weaponized. However, the natural properties of Hantaviruses pose a threat that can be exploited by conventional and unconventional forces. This review seeks to clarify the categorization of Hantaviruses as a bioweapon, whilst defining the practicality of employing New-World Hantaviruses and their effect on armies, infrastructure, and civilian targets.

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Immunocytochemical and Ultrastructural Evidence Supporting That Andes Hantavirus (ANDV) Is Transmitted Person-to-Person Through the Respiratory and/or Salivary Pathways

Cited by 17 publications

References 50 publications

The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism

The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism

HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients

Biodefense Implications of New-World Hantaviruses

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