Immunocytochemical localisation of parietal cells and G cells in the developing human stomach.

Kelly, Eric J.; Lagopoulos, M.; Primrose, John

doi:10.1136/gut.34.8.1057

Cited by 38 publications

(20 citation statements)

References 9 publications

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“…Thus while the inbred rodent strains used in most research may have more uniform patterns of gland geography, humans seem to possess a range of gland derivation patterns in the antrum. It is possible that these differences are related to genetic backgrounds, as examination of human fetal stomachs showed considerable heterogeneity in the distribution of parietal cells in the antrum 41. In our own work, we have found no evidence for age related effects on patterns of parietal cell distribution in the antrum.…”

Section: Discussioncontrasting

confidence: 64%

Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum

Choi

Roland

Barlow

et al. 2014

Gut

114

101

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Objective The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages within the human stomach. Design We determined the distribution of gastric gland cell lineages with specific immunocytochemical markers in entire stomach specimens from three non-obese organ donors. Results The anatomical body and antrum of the human stomach were defined by the presence of ghrelin and gastrin cells, respectively. Concentrations of somatostatin cells were observed in the proximal stomach. Parietal cells were seen in all glands of the body of stomach as well as in over 50% of antral glands. MIST1-expressing chief cells were predominantly observed in the body, although individual glands of the antrum also showed MIST1-expressing chief cells. While classically-described antral glands were observed with gastrin cells and deep antral mucous cells without any parietal cells, we also observed a substantial population of mixed-type glands containing both parietal cells and G cells throughout the antrum. Conclusions Enteroendocrine cells show distinct patterns of localization in the human stomach. The existence of antral glands with mixed cell lineages indicates that human antral glands may be functionally chimeric with glands assembled from multiple distinct stem cell populations.

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Section: Discussioncontrasting

confidence: 64%

Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum

Choi

Roland

Barlow

et al. 2014

Gut

114

101

View full text Add to dashboard Cite

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“…Secretory surface of highly located cells is by 40 % larger that that of basal cells. So, we can make a conclusion about adverse relationship with the level of basal secretion: in case with dogs it is low and in case with humans and rats it is comparatively high [28].…”

Section: Tissue Components Of Stomach Wall Coatsmentioning

confidence: 99%

“…When studying gastric parietal cells it was determined that they appear starting from the 13 th week and are localized in the fundic part as well as in the pyloric part and by the start of the third trimester they usually disappear from the pyloric part. But this process does not occur in case with each fifth fetus [24,28].…”

Section: Tissue Components Of Stomach Wall Coatsmentioning

confidence: 99%

Morphogenesis of Gastric Tissular Components and Immune Structures in Piglets

Gavrilina¹,

Gavrilin²

2018

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The monograph analyzes the problem of postnatal morphogenesis of tissue components, immune structures and lymphatic vessels of the stomach of piglets. It is established that the degree of differentiation and specialization of the main structures of the stomach wall in newborn piglets depends on their body weight (conformity of newborn piglets body weight to the breed standard). The results of analysis of the age-related changes of the main components of the porcine stomach wall in early postnatal ontogenesis are presented. The features of growth and development of immune structures of piglets gastric mucosa, lymphatic vessels and gastric lymph nodes during postnatal adaptation are interpretated.For scientists, lecturers and post-graduate students in the field of veterinary medicine, biotechnology and biology.

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“…[5][6][7] It is known that the capacity of the stomach to secrete hydrochloric acid is almost linearily related to parietal cell numbers. 8,9 From the end of the first trimester, parietal cells are present in a mature, functional form in the gastric mucosa with the potential to secrete gastric acid. 10 A normal human stomach contains approximately one billion parietal cells, which are capable of producing and concentrating hydrochloric acid 8 .…”

Section: Introductionmentioning

confidence: 99%

“…8,9 From the end of the first trimester, parietal cells are present in a mature, functional form in the gastric mucosa with the potential to secrete gastric acid. 10 A normal human stomach contains approximately one billion parietal cells, which are capable of producing and concentrating hydrochloric acid 8 . The quantity of acid produced by the stomach correlates with the functional capability and number of parietal cell mass.…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric Changes of The Parietal Cell of The Stomach with Age - A Postmortem Study

Begum

Nurunnabi

Shahriah

et al. 2014

J Bangladesh Soc Physiol

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Background: The quantity of acid produced by the stomach correlates with the functional capability and number of parietal cell mass. Researchers have found that the number of parietal cells tends to increase with advancing age in different population-based studies. Objective: A cross-sectional descriptive type of study was designed to see the variation in the number and diameter of the parietal cells of the stomach with advancing age in Bangladeshi people. Methods: The present study was done in the

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Immunocytochemical localisation of parietal cells and G cells in the developing human stomach.

Cited by 38 publications

References 9 publications

Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum

Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum

Morphogenesis of Gastric Tissular Components and Immune Structures in Piglets

Histomorphometric Changes of The Parietal Cell of The Stomach with Age - A Postmortem Study

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