Immunodiagnosis of Mycobacterial Infection

Bothamley, Graham; Catty, D.; Clifton-Hadley, R. S.; Griffin, Frank; Hewinson, R. Glyn; Pollock, J.M.

doi:10.1002/9781444311433.ch10

Search citation statements

Order By: Relevance

Paper Sections

Select...

Past and Present Use Of Ppd1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2012

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One TU is defined as 0.02 μg of PPD‐S (Edwards & Edwads, ). Five TU is the standard dose for intradermal diagnostic use, as determined from epidemiological studies (Bothamley et al ., ).…”

Section: Past and Present Use Of Ppdmentioning

confidence: 97%

Purified protein derivatives of tuberculin — past, present, and future

Yang

Kruh-Garcia

Dobos

2012

FEMS Immunol Med Microbiol

View full text Add to dashboard Cite

The tuberculin skin test, which involves monitoring the immune reaction to an injection of purified protein derivative (PPD), has been the most widely used method for detecting infection with Mycobacterium tuberculosis since its development in 1930s. Until recently, the molecular composition of PPD was unknown. This thwarted the discovery of improved skin testing reagents and drastically hindered efforts to define the mechanism of action. Proteomic evaluation of PPD combined with a detailed analysis in the guinea pig model of tuberculosis led to further definition of the molecular composition of PPD. This communication reviews the history and current status of PPD, in addition to describing candidate next‐generation PPD reagents, based on the use of an individual protein or protein cocktails.

show abstract

Section: Past and Present Use Of Ppdmentioning

confidence: 97%