Immunodominant T Cell Peptides from Four Candidate Malarial Antigens as Biomarkers of Protective Immunity Against Malaria

Belmonte, María; Ganeshan, Harini; Huang, Jun; Belmonte, Arnel; Inoue, Sandra; Velasco, Rachel; Acheampong, Neda; Ofori, Ebenezer Addo; Akyea-Mensah, Kwadwo; Frimpong, Augustina; Ennuson, Nana Aba; Frempong, Abena Fremaah; Kyei-Baafour, Eric; Amoah, Linda Eva; Edgel, Kimberly A.; Peters, Bjoern; Villasante, Eileen; Kusi, Kwadwo Asamoah

doi:10.2139/ssrn.4141057

Cited by 1 publication

(2 citation statements)

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“…Other cells, such as the Gamma Delta (gd) T cells also kill intrahepatic parasites through secretion of type I interferons and IFN-g (36)(37)(38)(39)(40). There is growing evidence of the effectiveness of CD8+ T cells that secrete IFN-and granzyme B at killing infected hepatocytes (20,41). The failure of these mechanisms leads sporozoites to undergo sporogony in the hepatocytes and develop into merozoites.…”

Section: Pre-erythrocytic Stagementioning

confidence: 99%

“…They act as messengers that help immune cells to communicate with one another in a concerted effort to clear infected Red Blood Cells (RBCs). Responses elicited by activated CD8+ T cells occur through the secretion of effector cytokines such as Interferon gamma (IFNg) (20). Memory CD8+ T cells are also maintained by cytokines such as IL-7 and IL-15 (21).…”

Section: Introductionmentioning

confidence: 99%

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Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome

Segbefia,

Asandem,

Amoah

et al. 2024

Front. Immunol.

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Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with Plasmodium parasites and immunization outcomes during routine administration of malaria vaccines. These polymorphisms can increase or reduce susceptibility to this deadly infection, and this may affect the physiologically needed balance between anti-inflammatory and pro-inflammatory cytokines. The purpose of this review is to present an overview of the effect of selected cytokine gene polymorphisms on immune responses against malaria.

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Section: Pre-erythrocytic Stagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%