2013
DOI: 10.1002/jemt.22271
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Immunoelectron microscopic observation of connexin43 in rat odontoblasts

Abstract: Gap junctions play an important role in differentiation of odontoblasts. Gap junction protein, connexin 43 is expressed in odontoblast. However, the detailed localization in odontoblasts has yet to be fully investigated. We investigated the localization of connexin43 in rat odontoblasts immuno-electron microscopically. The rats were transcardially fixed with 1% paraformaldehyde in 0.1M phosphate buffer, and mandibles were decalcified with 10% ethylenediamine tetraacetic acid. Pre-embedding method was carried o… Show more

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Cited by 5 publications
(3 citation statements)
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“…Odontoblasts express connexin (Cx) hemi-channels, forming a gap junction and establishing cell–cell communication (Goldberg et al, 1981 ; Sasaki et al, 1982 ; Callé, 1985 ; Goldberg and Sasaki, 1985 ; About et al, 2001 ; Muramatsu et al, 2004 ; Ikeda and Suda, 2013 ). Connexin 43, a gap junction protein, is expressed in odontoblasts (Ikeda and Suda, 2013 ; Muramatsu et al, 2013 ), and seems to play a role in electrical communication between odontoblasts. It has been reported that connexin 43 also releases ATP extracellularly in the pathological setting, such as low (almost 0 mM) extracellular Ca 2+ circumstance or high (c.a.…”
Section: Discussionmentioning
confidence: 99%
“…Odontoblasts express connexin (Cx) hemi-channels, forming a gap junction and establishing cell–cell communication (Goldberg et al, 1981 ; Sasaki et al, 1982 ; Callé, 1985 ; Goldberg and Sasaki, 1985 ; About et al, 2001 ; Muramatsu et al, 2004 ; Ikeda and Suda, 2013 ). Connexin 43, a gap junction protein, is expressed in odontoblasts (Ikeda and Suda, 2013 ; Muramatsu et al, 2013 ), and seems to play a role in electrical communication between odontoblasts. It has been reported that connexin 43 also releases ATP extracellularly in the pathological setting, such as low (almost 0 mM) extracellular Ca 2+ circumstance or high (c.a.…”
Section: Discussionmentioning
confidence: 99%
“…While bordering columnar cells and central stellate-reticulum-like cells show significant staining, ameloblast-like cells show no-to-weak expression. Because Cnx43 is downregulated, one could be inclined to speculate that ameloblastoma and odontogenic keratocyst have the potential to become malignant ( Muramatsu et al, 2013 ).…”
Section: Discussionmentioning
confidence: 99%
“…112 Microscopic observations indicate the localization of gap junctions between the bodies of odontoblasts and between the bodies and processes of odontoblasts. 113 Similarly, Cx26 is expressed at low levels in the odontoblast layer, while Cx32 is not detected in odontoblasts. 90 In carious teeth, Cx43 expression is upregulated in mature odontoblasts in the vicinity of carious lesions, combined with the prominent expression of Cx43 in the interodontoblastic cells.…”
Section: Connexins In Oral Diseasesmentioning
confidence: 99%