Immunoexpression of glucocorticoid receptor alpha (<scp>GR</scp>α) isoform and apoptotic proteins (Bcl‐2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma

Sena, Luana Samara Balduino de; Silveira, Éricka Janine Dantas da; Batista, Aline Carvalho; Mendonça, Elismauro Francisco; Alves, Pollianna Muniz; Nonaka, Cassiano Francisco Weege

doi:10.1111/jop.12757

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…30 However, the participation of GR-α in lip carcinogenesis does not involve modulation of the expression of Bax or Bcl-2. 31 Thus, the direct and indirect interaction between GR-α and Bax or Bcl-2 in L-OHP-induced peripheral neuropathy needs further investigation. Throughout the years, many different mechanisms have been proposed explaining how GR inhibits pro-inflammatory gene expression, including direct mechanisms as well as feedback loop mecha-nisms by GC-induced anti-inflammatory proteins.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

Shan-shan¹,

Yang²,

Sun

et al. 2020

Eur J Inflamm

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Oxaliplatin (L-OHP) has been widely used in the treatment of various tumors, especially in colorectal cancer. The mechanism of peripheral neurotoxicity induced by L-OHP (OIPN) is unclear and current therapeutic options only serve to alleviate the symptoms rather than prevent OIPN. To observe the effects of electroacupuncture (EA) stimulation on OIPN in rats, rats were randomly divided into the control group, OIPN model group, and OIPN + EA group. To establish OIPN rat models, a single intraperitoneal injection with 10 mg/kg L-OHP in the OIPN model rats. Rats in the control group received a single intraperitoneal injection with 0.9% lactose. From the third day after establishing OIPN models, the rats were treated with EA. Cold allodynia and heat sensitivity were assessed using the acetone drop and the Hargreaves method, respectively. Pathological changes in nerves were detected using hematoxylin and eosin (H&E) staining and transmission electron microscopy. Related mRNA and protein expression levels were measured by real-time polymerase chain reaction (PCR) and western blotting from 14 days after establishing OIPN models. Our results showed that L-OHP significantly increased the sensitivity to cold allodynia and nervous injury, which were ameliorated after EA treatment. The expression of glucocorticoid receptor alpha (GR-α) and B-cell lymphoma 2 (Bcl-2) was significantly decreased and that of Bax was significantly increased in sciatic nerve of OIPN model rats compared with control rats. However, EA treatment significantly inhibited L-OHP-induced protein expressions in rats. Moreover, compared with the control rats, the nucleus NF-κBp65 levels were significantly increased, while the cytoplasm NF-κBp65 levels were significantly decreased, which were reversed by EA treatment. In conclusion, EA treatment may reduce peripheral neurotoxicity induced by L-OHP through regulating related protein expression.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

Shan-shan¹,

Yang²,

Sun

et al. 2020

Eur J Inflamm

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“…Together, these findings suggest that GR may contribute to the malignant phenotypes of solid tumors as a component of the cancer-associated GC (CAG) system. Reinforcing our hypothesis, previous studies have reported that GR acts as an oncoprotein and regulates the malignant phenotypes in stem-like cells and lip cancer (de Sena et al, 2018;Wang et al, 2015).…”

Section: Discussionsupporting

confidence: 90%

Glucocorticoid reduces the efficacy of afatinib on the head and neck squamous cell carcinoma

WANG¹,

Chen²,

Huang³

et al. 2023

Biocell

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Glucocorticoids (GC) are widely used to counter the adverse events during cancer therapy; nonetheless, previous studies pointed out that GC may reduce the efficacy of chemotherapy on cancer cells, especially in epidermal growth factor receptor (EGFR)-targeted therapy of head and neck squamous cell carcinoma (HNSCC) remaining to be elucidated. The primary aim of the present study was to probe into the GC-induced resistance of EGFR-targeted drug afatinib and the underlying mechanism. HNSCC cell lines (HSC-3, SCC-25, SCC-9, and H-400) and the human oral keratinocyte (HOK) cell lines were assessed for GC receptor (GR) expression. The promoting tumor growth effect of GC was evaluated by the CCK-8 assay and flow cytometry. Levels of signaling pathways participants GR, mTOR, and EGFR were determined by quantitative polymerase chain reaction and western blotting. GC increased the proliferation of HNSCC cells in a GR-dependent manner and promoted AKT/mTOR signaling. But GC failed in counteracting the inhibition of rapamycin in the mTOR signaling pathway. Besides, GC also induced resistance to EGFR-targeted drug afatinib through AKT/mTOR instead of the EGFR/ERK signaling pathway. Thus, GCs reduce the efficacy of afatinib on HNSCC, implicating a cautious use of glucocorticoids in clinical practice.

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Effects of photobiomodulation with blue Light Emitting Diode (LED) on the healing of skin burns

de Alencar Fernandes Neto,

Simões,

de Oliveira

et al. 2023

Lasers Med Sci

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Immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl‐2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma

Cited by 7 publications

References 27 publications

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

Glucocorticoid reduces the efficacy of afatinib on the head and neck squamous cell carcinoma

Effects of photobiomodulation with blue Light Emitting Diode (LED) on the healing of skin burns

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