Immunogenetic factors in mycosis fungoides: can the <scp>HLA</scp> system influence the susceptibility and prognosis of the disease? Long‐term follow‐up study of 46 patients

Brazzelli, Valeria; Rivetti, Nicolò; Badulli, C.; Carugno, Andrea; Grasso, Vincenzo; Silvestri, Annalisa De; Martinetti, Miryam; Borroni, G.

doi:10.1111/jdv.12391

Cited by 12 publications

(21 citation statements)

References 22 publications

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“…One of the HLA class I alleles (ligands for KIR) that regulate antitumour NK toxicity interacting with KIRs is HLA‐A24. HLA‐A*24 allele frequency was higher, in a statistically significant manner, in MF than in controls, as previously reported in our study …”

Section: Discussionsupporting

confidence: 93%

“…The study includes 46 Caucasian patients already included in a recent work published by our group. 4 Patients were divided into two groups: the first one composed of 39 patients, defined as "long survivors" (31 have shown no clinical recurrence of disease after therapy; eight still have MF in patches resistant to skin directed therapy, or relapsing few months after the clinical remission); the second one composed of seven patients who died for the clinical worsening of the disease. 4 All patients were in stage IA or IB when they entered the study.…”

Section: Population Studymentioning

confidence: 99%

“…4 Patients were divided into two groups: the first one composed of 39 patients, defined as "long survivors" (31 have shown no clinical recurrence of disease after therapy; eight still have MF in patches resistant to skin directed therapy, or relapsing few months after the clinical remission); the second one composed of seven patients who died for the clinical worsening of the disease. 4 All patients were in stage IA or IB when they entered the study. Differently from patients of the first group ("long survivors"), who maintained the same stage over the follow-up time, the patients of the second group progressed to more advanced stages (stages IIB and IVA), and they died because of a clinical evolution of the disease, with the development of nodules and tumours, ulceration of lesions and lymph node involvement without visceral involvement.…”

Section: Population Studymentioning

confidence: 99%

“…However, skin tumour infiltrates contain a considerable proportion of CD8+ and natural killer (NK) cells that are under the control of HLA class I molecules. 3 In our recent study about the correlation between HLA polymorphisms and prognosis in MF, 4 HLA-A*24 allele was found to be involved in the susceptibility of MF, while HLA-B*35 allele was typical of dead patients. Both these alleles belong to HLA class I.…”

Section: Introductionmentioning

confidence: 98%

“…In our recent study about the correlation between HLA polymorphisms and prognosis in MF, HLA‐A*24 allele was found to be involved in the susceptibility of MF, while HLA‐B*35 allele was typical of dead patients. Both these alleles belong to HLA class I.…”

Section: Introductionmentioning

confidence: 99%

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Mycosis fungoides: association of KIR ligands and HLA‐DQB1*05 with bad prognosis of the disease

Brazzelli

Rivetti

Badulli³

et al. 2015

Acad Dermatol Venereol

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Section: Discussionsupporting

confidence: 93%

Section: Population Studymentioning

confidence: 99%

Section: Population Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mycosis fungoides: association of KIR ligands and HLA‐DQB1*05 with bad prognosis of the disease

Brazzelli

Rivetti

Badulli³

et al. 2015

Acad Dermatol Venereol

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High‐throughput RNA sequencing of the T cell receptor alpha and beta chains for simultaneous clonality and biological analyses in Sezary syndrome

Blanco,

López‐Aventín,

Pujol

et al. 2023

Clinical Laboratory Analysis

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BackgroundPrevious investigations pointed out a role for antigen stimulation in Sezary syndrome (SS). High‐throughput sequencing of the T cell receptor (TR) offers several applications beyond diagnostic purposes, including the study of T cell pathogenesis.MethodsWe performed high‐throughput RNA sequencing of the TR alpha (TRA) and beta (TRB) genes focusing on the complementarity‐determining region 3 (CDR3) in 11 SS and one erythrodermic mycosis fungoides (MF) patients. Five psoriasis patients were employed as controls. Peripheral blood CD4+ cells were isolated and RNA sequenced (HiSeq2500). High‐resolution HLA typing was performed in neoplastic patients.ResultsHighly expanded predominant TRA and TRB CDR3 were only found in SS patients (median frequency: 94.4% and 93.7%). No remarkable CDR3 expansions were observed in psoriasis patients (median frequency of predominant TRA and TRB CDR3: 0.87% and 0.69%, p < 0.001 compared to SS). CDR3 almost identical to the predominant were identified within each SS patient and were exponentially correlated with frequencies of the predominant CDR3 (R2 = 0.918, p < 0.001). Forty‐six different CDR3 were shared between SS patients displaying HLA similarities, including predominant TRA and TRB CDR3 in one patient that were found in other three patients. Additionally, 351 antigen matches were detected (Cytomegalovirus, Epstein–Barr, Influenza virus, and self‐antigens), and the predominant CDR3 of two different SS patients matched CDR3 with specificity for Influenza and Epstein–Barr viruses.ConclusionsBesides detecting clonality, these findings shed light on the nature of SS‐related antigens, pointing to RNA sequencing as a useful tool for simultaneous clonality and biological analysis in SS.

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Pediatric mycosis fungoides: a study of the human leukocyte antigen system among Israeli Jewish patients

et al. 2017

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Pediatric mycosis fungoides (MF) is a rare disease characterized by over-representation of atypical clinical variants, with a different prognosis from adult MF. Several human leukocyte antigen (HLA) alleles have been associated with MF in certain adult populations, including Israeli Jews. However, HLA data on pediatric MF as a group are lacking. To evaluate the possible association of the HLA system with pediatric MF, 59 Israeli Jewish patients diagnosed with MF at age ≤ 18 years underwent high- and intermediate-resolution genotyping for HLA class I (HLA-A*, HLA-B*) and class II (HLA-DRB1*, DQB1*) loci. The results were compared with data on 4169 umbilical cord blood units retrieved from a public cord blood bank in Jerusalem and samples from 252 healthy, unrelated Israeli Jewish volunteers. No statistically significant associations were found between pediatric MF and any of the alleles examined except HLA-B*73. However, given the extremely low frequency of B*73 in both the control group (0.1%) and the study group (2%), the biological significance of this finding is questionable. Further subgroup analyses by ethnicity (Ashkenazi and non-Ashkenazi) and clinicopathologic variant (follicular and non-follicular) yielded no significant between-group differences. These results suggest that the associations with the HLA system, reported previously in adult MF, do not hold true for pediatric MF. Thus, pediatric MF differs from its adult counterpart not only in clinical manifestations and course, but apparently also in the underlying immuno-pathogenetic mechanism.

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Immunogenetic factors in mycosis fungoides: can the HLA system influence the susceptibility and prognosis of the disease? Long‐term follow‐up study of 46 patients

Abstract: This study suggests that the prognosis of MF patients is not only correlated with clinical/pathological/serological/immunological variables but it also relies on specific HLA alleles.

Cited by 12 publications

References 22 publications

Mycosis fungoides: association of KIR ligands and HLA‐DQB1*05 with bad prognosis of the disease

Mycosis fungoides: association of KIR ligands and HLA‐DQB1*05 with bad prognosis of the disease

High‐throughput RNA sequencing of the T cell receptor alpha and beta chains for simultaneous clonality and biological analyses in Sezary syndrome

Pediatric mycosis fungoides: a study of the human leukocyte antigen system among Israeli Jewish patients

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