Immunogenetic features of juvenile rheumatoid arthritis

Zolobova, E S; Yasdovsky, V V; Voronin, A. V.; Boldyreva, M P

doi:10.14412/1995-4484-2007-24

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…(1)(2)(3) Characteristics associated with these conditions are familial susceptibility, existence of the pathogenetic or associated markers of the disease predisposition, the variability of clinical implications depending on gender and age, lower level of coincidence on a disease at monochorial twins, and others. (4) The human leukocyte antigen (HLA) class I molecule HLAB27 was the first genetic risk factor identified as associating with JAS and remains the most important risk locus for this archetypal spondyloarthropathy. (5) The important role of HLA-B27 in JA pathogenesis has been known for a long time.…”

Section: Introductionmentioning

confidence: 99%

The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia

Kurtanov¹,

Vinokurova²,

Pavlova³

et al. 2019

IJBM

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The research objective was to conduct a retrospective study of patients with Juvenile arthritis (JA) in association with the carriage of the HLA-B27 allele. Materials and Methods: A total of 73 patients (39 boys and 34 girls aged from 1 to 16 years, mean age of 10.28±4.24 years) living in Yakutia with Juvenile Chronic Arthritis (JCA), Juvenile Ankylosing Spondylitis (JAS), Juvenile Psoriatic Arthritis (JPsA), and reactive arthritis (RA) were examined. Among them, 62(84.9%) children were of Yakut nationality, and 11(15.1%)the Russian nationality. The control group included 85 Yakuts without clinical diagnosis of arthritis. Testing for the HLA-B27 allele was performed according to Dominquez et al. (1992) as modified by Steffens-Nakken et al. (1995). Results: According to the genotyping results, in 30 of 73 examined samples an association was found between the HLA-B27 allele carriage and JA. The HLA-B27 allele was diagnosed in 24 (38.7%) Yakuts and 6 (54.5%) ethnic Russians. For further analysis, all patients (Yakuts, Russians) were divided into diagnosis-related groups. Diagnoses of JAS (n=10) and JCA (n=9) prevailed in Yakuts. In the Russian children, RA was more common (n=4). In population sampling of Yakuts, the frequency of the HLA-B27 allele was 32.9%. A comparison of the frequencies of the HLA-B27 allele among the Yakut patient groups and the control group found a statistically significant association with JAS. The carriage of the HLA-B27 allele in Yakut females did not increase the risk of JAS development, whereas in male Yakuts this risk increased by 5.6 times.

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Section: Introductionmentioning

confidence: 99%

The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia

Kurtanov¹,

Vinokurova²,

Pavlova³

et al. 2019

IJBM

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“…В последние годы большое внимание уделяется изучению клеточноопосредованных реакций и их роли в становлении и прогрессировании ювенильного ревматоидного артрита (ЮРА) [1,2]. На сегодня установлено, что эффективность Т-клеточной активации зависит от специфичности HLA-аллелей.…”

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Immunogenetic Indicators as Markers of Aggressive Flow and Efficiency of Basic Therapy in Rheumatoid Arthritis in Children

Saatova

Maimerova

Ganieva

2019

BSP

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The immunological and immunogenetic features of juvenile rheumatoid arthritis in the Kyrgyz population are studied for the first time. The study was conducted in 30 healthy children and 67 patients aged 3 to 16 years. The method of rosette formation was used. Associative links were established in the systemic form of juvenile rheumatoid arthritis with histocompatibility antigens in the HLA Cw5, B12 system, and the B15, A2, A9 antigens with high activity of the process, early development of bone and cartilage destruction and functional impairments. In the first 6 months of disease, it recommended the appointment of an aggressive baseline therapy.

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Immunogenetic features of juvenile rheumatoid arthritis

Cited by 2 publications

References 22 publications

The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia

The Molecular Genetic Features of Patients with Juvenile Arthritis in Yakutia

Immunogenetic Indicators as Markers of Aggressive Flow and Efficiency of Basic Therapy in Rheumatoid Arthritis in Children

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