Immunogenicity of a Haemophilus influenzae type b–tetanus conjugate vaccine when administered separately or in combined vaccines for primary immunization in two consecutive national schedules in Turkey

Yüksel, Nurullah; Beyazova, Ufuk; Balci, I.; Aksakal, Fatma Nur; Çamurdan, Aysu Duyan; Sahın, Figen; Rota, Seyyal

doi:10.1016/j.ijid.2012.01.005

Cited by 4 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in line with previous observations suggesting that lower antibody responses to Hib are induced by combined vaccines containing acellular pertussis compared to separate injections. 6,7,[16][17][18] Previous studies have shown that lower anti-PRP antibody levels were induced in infants who received 3 primary doses of the combined vaccine as compared to separate injections of DTPa-IPV and Hib, or separate injections of DTPa, oral polio vaccine and Hib. 6,7,18 In another study conducted in infants primed with a single dose of DTPa vaccine, lower levels of anti-PRP, anti-T, and anti-poliovirus type 1 antibodies were also observed in the infants who received 2 subsequent doses of the combined DTPa-IPV/Hib vaccine compared with separate injections.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,[16][17][18] Previous studies have shown that lower anti-PRP antibody levels were induced in infants who received 3 primary doses of the combined vaccine as compared to separate injections of DTPa-IPV and Hib, or separate injections of DTPa, oral polio vaccine and Hib. 6,7,18 In another study conducted in infants primed with a single dose of DTPa vaccine, lower levels of anti-PRP, anti-T, and anti-poliovirus type 1 antibodies were also observed in the infants who received 2 subsequent doses of the combined DTPa-IPV/Hib vaccine compared with separate injections. 16 Nevertheless, it was also previously suggested that the lower immune responses to the combined vaccine were not associated with an impaired function of the induced antibodies, nor with induction of immune memory against Hib.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunogenicity and safety of a combined DTPa-IPV/Hib vaccine administered as a three-dose primary vaccination course in healthy Korean infants: phase III, randomized study

Kim

et al. 2018

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

We assessed the immunogenicity and safety of a three-dose primary vaccination schedule with the combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus/Haemophilus influenzae type b vaccine (DTPa-IPV/Hib) in Korean infants. In this phase III open-label, multicenter study (NCT01309646), healthy infants aged 42–69 days (randomized 1:1) received three doses of either pentavalent DTPa-IPV/Hib (DTPa-IPV/Hib group) or DTPa-IPV and Hib vaccines administered separately (DTPa-IPV+Hib group) at 2, 4, 6 months of age. The primary objective was to demonstrate non-inferiority of DTPa-IPV/Hib compared to DTPa-IPV+Hib vaccines in terms of immune responses to all vaccine antigens, 1 month post-dose 3. Solicited symptoms (local and general) were recorded during 4 days, and unsolicited adverse events (AEs) during 31 days, after each vaccination. Serious AEs (SAEs) were recorded throughout the study duration. The immunogenicity of the pentavalent DTPa-IPV/Hib vaccine was non-inferior compared to concomitant administration of DTPa-IPV+Hib vaccines. One month post-dose 3, nearly all infants had antibody levels above the seroprotective thresholds for anti-diphtheria toxoid, anti-tetanus toxoid, anti-polyribosyl-ribitol phosphate, and anti-poliovirus type 1, 2 and 3, and had antibody levels above the seropositive thresholds for anti-pertussis toxoid (PT), anti-filamentous hemagglutinin (FHA) and anti-pertactin (PRN) antibodies. A vaccine response for PT, FHA and PRN was observed in at least 96.7% of study participants. Anti-PRP geometric mean concentrations appeared lower for the DTPa-IPV/Hib group (8.456 µg/mL) than for the DTPa-IPV+Hib group (18.700 µg/mL). In both groups, the most common solicited symptoms were injection site redness and irritability. Fifty-seven SAEs were reported throughout the study; none were considered to be vaccination related.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immunogenicity and safety of a combined DTPa-IPV/Hib vaccine administered as a three-dose primary vaccination course in healthy Korean infants: phase III, randomized study

Kim

et al. 2018

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…We read with interest the article by Yü ksel et al 1 on the immunogenicity of the Haemophilus influenzae type b-tetanus conjugate vaccine when administered separately or in combined form in Turkey, and congratulate them on their study.…”

mentioning

confidence: 99%