Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy

Sahin, Onur; Ashokkumar, Meiyazhagan; Ajayan, Pulickel M.; Krishnan, Sunil

doi:10.3390/cancers12123559

Cited by 8 publications

(8 citation statements)

References 55 publications

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“…There are several physical approaches for inducing hyperthermia, including electromagnetic radiation, ultrasound, hyperthermic perfusion, and conductive heating [ 10 ]. Nanoparticles with appropriate external energy sources are being used for local treatment [ 45 , 46 , 47 ]. Strategies to enhance the therapeutic efficacy of hyperthermia are also under investigation; in this context cytotoxic properties of hyperthermia on leukemia, melanoma, lung carcinoma, and colon cancer cells, among others, have been improved by the use of compounds that sensitize to the cells [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

Quintana

Saavedra

Rosario

et al. 2021

IJMS

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Ethanol has been shown to exhibit therapeutic properties as an ablative agent alone and in combination with thermal ablation. Ethanol may also increase sensitivity of cancer cells to certain physical and chemical antitumoral agents. The aim of our study was to assess the potential influence of nontoxic concentrations of ethanol on hyperthermia therapy, an antitumoral modality that is continuously growing and that can be combined with classical chemotherapy and radiotherapy to improve their efficiency. Human leukemia cells were included as a model in the study. The results indicated that ethanol augments the cytotoxicity of hyperthermia against U937 and HL60 cells. The therapeutic benefit of the hyperthermia/ethanol combination was associated with an increase in the percentage of apoptotic cells and activation of caspases -3, -8 and -9. Apoptosis triggered either by hyperthermia or hyperthermia/ethanol was almost completely abolished by a caspase-8 specific inhibitor, indicating that this caspase plays a main role in both conditions. The role of caspase-9 in hyperthermia treated cells acquired significance whether ethanol was present during hyperthermia since the alcohol enhanced Bid cleavage, translocation of Bax from cytosol to mitochondria, release of mitochondrial apoptogenic factors, and decreased of the levels of the anti-apoptotic factor myeloid cell leukemia-1 (Mcl-1). The enhancement effect of ethanol on hyperthermia-activated cell death was associated with a reduction in the expression of HSP70, a protein known to interfere in the activation of apoptosis at different stages. Collectively, our findings suggest that ethanol could be useful as an adjuvant in hyperthermia therapy for cancer.

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Section: Discussionmentioning

confidence: 99%

Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

Quintana

Saavedra

Rosario

et al. 2021

IJMS

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“…The next limitation is that the physiological response of nano-carriers is yet not very well understood. For example, studies showed that the crystalline silver nanoparticles might cause cytotoxicity in the human fibroblasts, keratinocytes, lesioned skin [31]. Liposomal vesicles can be arrested by the immune system [32].…”

Section: Limitations Of Nanoparticles In Drug-delivery Systemmentioning

confidence: 99%

Nanoparticles in Cancer Treatment: A Narrative Review

Hassan

Huang

Zhou

et al. 2022

PPASB

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Nanoparticles have revolutionized the world with their enormous blessings specifically in cancer treatment. In past, conventional chemotherapy was the primary choice of treatment for patients. However, chemotherapeutics also had several pharmaceutical limitations such as stability, drug-drug interaction, drug resistance, and aqueous solubility. Reciprocally, dose curbing toxicity is significant with non-specific toxicity to healthy cells, loss of appetite, hair loss, peripheral neuropathy, vomiting, muscular fatigue, and diarrhea being the typical adverse effects. The introduction of multi-drug resistance (MDR) also posed a great threat for successful cancer treatment, whereby the tumor cells became resistant to many of the chemotherapeutic agents used. Nanotechnology-based novel chemotherapy opened a new horizon for the treatment of cancer. Particularly, nanoparticle-related medication is a highly potential newcomer for curtailing systemic toxicity via producing functionalized particles for specific treatment. It is also an alternative to circumvent multidrug resistance for possessing an ability to bypass the efflux mechanism correlated with this phenotype. Besides having various advantages in treatment, nanoparticles are also playing a key role in diagnostic entities. This paper aims to specifically outline the role of nanotechnology which it is playing in today’s era in the diagnosis and treatment of cancer with contemporary knowledge. To assess the role of nanoparticles in cancer treatment, this review analyzed all articles published from 2002 to 2021 in both Local and foreign journals. The article’s inclusion criteria were based on the article which contained relevant data regarding applications of nanoparticles in cancer treatment. Articles with copyright, irrelevant information, and lacking the full text were excluded. This paper will highlight the breakthrough, impediments, and prospects of nanoparticles in cancer treatment with an updated review.

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“…where (ηC, ηS) and (ρC, ρS) are the corresponding fractions of diminished mass and densities of the core Fe3O4 and shell GA, respectively. Using the parameters ηC = 0.75 and ηS = 0.25 obtained from Figure 4) for MNP-GA1, as well as ρC = 5.18 g/cm 3 and ρS = 1.4 g/cm 3 as the densities of Fe3O4 and GA, respectively, it is estimated that ΔMNP-GA1 = 1.7 nm. In the same way, using ηC = 0.84 and ηS = 0.16, the thickness for MNP-GA2 is ΔMNP-GA2 = 1.1 nm.…”

Section: Physicochemical Characterization Of the Ga-coated Mnpsmentioning

confidence: 99%

“…The corresponding values are depicted in Figure 7b. Due to the small value of η, the parameter P involves ρ FF = 1.0 g/cm 3 and c v = 4.18 J/(kg × K) which are the same as water. Additionally, Figure 7b shows the regression of the experimental measurements, fitting the mathematical expression P = B × H 2 and getting B = 0.2 W/(cm 3 Am −1 ) 2 as the proportionality constant (with R 2 = 0.999 of correlation).…”

Section: Physicochemical Characterization Of the Ga-coated Mnpsmentioning

confidence: 99%

“…For example, NPs have a high surface-to-volume ratio that provides extremely reactive and versatile properties. Magnetic nanoparticles (MNPs) have found numerous applications in biomedicine fields, such as magnetophoresis, drug delivery, nuclear magnetic resonance imaging (NMRI), and hyperthermia [2,3]. Additionally, MNPs can be manipulated by high gradients of magnetic fields [1].…”

Section: Introductionmentioning

confidence: 99%

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A Ferrofluid with High Specific Absorption Rate Prepared in a Single Step Using a Biopolymer

et al. 2022

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An exhaustive characterization of the physicochemical properties of gum arabic (GA)-coated Fe3O4 magnetic nanoparticles was conducted in this work. These nanoparticles were obtained via the in-situ coprecipitation method (a fast single-step method) in two GA:Fe ratios, 10:1 and 20:1, respectively. Several experimental techniques were applied in the characterization process, all of them described below. Using Transmission Electron Microcopy images, they were shown to have spherical-like morphology with 11 nm diameter. The Fourier Transform Infrared spectra confirmed the attachment of the GA on the surface of the magnetic nanoparticles (MNPs), providing good colloidal stability from pH 7 to 8. The thickness of the coatings (1.7 nm and 1.1 nm) was determined using thermogravimetric measurements. A high specific absorption rate and superparamagnetic properties were determined using alternant and static magnetic fields, respectively. The GA-coated MNPs were non-cytotoxic, according to tests on HT-29 human intestine cells. Additionally, HT-29 cells were exposed to magnetic fluid hyperthermia at 530 kHz, and the induction of cell death by the magnetic field, due to the heating of GA-coated MNP, was observed.

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Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy

Cited by 8 publications

References 55 publications

Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

Nanoparticles in Cancer Treatment: A Narrative Review

A Ferrofluid with High Specific Absorption Rate Prepared in a Single Step Using a Biopolymer

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