2017
DOI: 10.4172/jpb.1000454
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Immunogenicity Prediction by VaxiJen: A Ten Year Overview

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Cited by 32 publications
(20 citation statements)
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References 114 publications
(129 reference statements)
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“…The four viral proteins (Supplementary File 1) of COVID-19, HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, MERS-CoV, HKU4, HKU5 and BufCoV-HKU26 were employed to determine the most antigenic sites by using B cell epitope prediction tool of IEDB and VaxiJen scoring. VaxiJen server which was well above the threshold value (0.40), usually reveal the immunogenic potential to stimulate protective response in the host organisms [17]. From the analysis, a total of 17 epitopes from S proteins, 1 epitopes from M proteins, 1 epitopes from E proteins and 5 epitopes from N proteins were found mostly immunogenic in COVID-19 with almost 100% peptides carrying more than threshold value of antigenic score of VaxiJen server (Table 2).…”
Section: Immunogenicity Prediction and Epitope Conservancy Analysismentioning
confidence: 95%
“…The four viral proteins (Supplementary File 1) of COVID-19, HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, MERS-CoV, HKU4, HKU5 and BufCoV-HKU26 were employed to determine the most antigenic sites by using B cell epitope prediction tool of IEDB and VaxiJen scoring. VaxiJen server which was well above the threshold value (0.40), usually reveal the immunogenic potential to stimulate protective response in the host organisms [17]. From the analysis, a total of 17 epitopes from S proteins, 1 epitopes from M proteins, 1 epitopes from E proteins and 5 epitopes from N proteins were found mostly immunogenic in COVID-19 with almost 100% peptides carrying more than threshold value of antigenic score of VaxiJen server (Table 2).…”
Section: Immunogenicity Prediction and Epitope Conservancy Analysismentioning
confidence: 95%
“…In addition, use of this approach is not feasible with peptides that bind to MHC‐II molecules as the peptide binding sequence motifs are generally more degenerate than those binding to MHC‐I molecules. Predicted motifs may contain an equal number of false positives, predicted peptide epitopes may not be actual epitopes, and there may be an equal number of false negatives (i.e., peptides not predicted to be epitopes but which are in fact epitopes) . Anchor residues play an integral part in making an effective vaccine by altering their positions …”
Section: T‐cell Epitope Prediction Methodsmentioning
confidence: 99%
“…This method solves numerically the time‐dependent behavior of a molecular system on a microscopic scale and provides detailed information on the structure and conformational changes in proteins and their associated thermodynamic properties . The use of MD simulations does not rely on the availability of binding data (IC50) to make predictions, as it requires only the experimentally determined structure of the proteins involved . MD simulations have enabled the search of epitopes by the direct assessment of the free energy of binding between two peptides .…”
Section: T‐cell Epitope Prediction Methodsmentioning
confidence: 99%
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