Immunogenicity trial of inactivated hepatitis A virus vaccine in human volunteers

Kusov, Yu. Yu.; Elbert, L. B.; Nelga, I.V.; Grishina, G.K.; Dunaevski, O.A.; Kharin, N.V.; Maslov, Yu.N.; Drozdov, S. G.; Balayan, M. S.

doi:10.1016/0264-410x(91)90238-2

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…If administered within 2 wk after exposure, either development of the disease is prevented or the severity of the disease is attenuated as well as virus shedding is reduced [95,96,103] . Since 1992, inactivated vaccines are available [104][105][106] , which protect against both infection and disease caused by all strains of HAV with 100% efficacy for at last 10 years. Live, attenuated vaccines have been developed using virus adapted to growth in cell culture [107] , but were poorly immunogenic [108] .…”

Section: Havmentioning

confidence: 99%

Innate and adaptive immune responses against picornaviruses and their counteractions: An overview

Dotzauer

Kraemer

2012

WJV

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Picornaviruses, small positive-stranded RNA viruses, cause a wide range of diseases which is based on their differential tissue and cell type tropisms. This diversity is reflected by the immune responses, both innate and adaptive, induced after infection, and the subsequent interactions of the viruses with the immune system. The defense mechanisms of the host and the countermeasures of the virus significantly contribute to the pathogenesis of the infections. Important human pathogens are poliovirus, coxsackievirus, human rhinovirus and hepatitis A virus. These viruses are the beststudied members of the family, and in this review we want to present the major aspects of the reciprocal effects between the immune system and these viruses.

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Section: Havmentioning

confidence: 99%

Innate and adaptive immune responses against picornaviruses and their counteractions: An overview

Dotzauer

Kraemer

2012

WJV

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“…In case of SARS-CoV-2, the viruses are cultured in Vero cells and chemically inactivated [121]. Successful inactivated human pathogens as vaccines include Influenza, Hepatitis A and poliomyelitis [123][124][125]. The inactivated vaccines are safer to use and relatively easy to produce [126]; they express surface antigens that retain their epitope conformations to induce strong preventative humoral responses [127].…”

Section: Current Progresses In Prophylactic and Therapeutic Treatment...mentioning

confidence: 99%

Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome

Shin

Kim

Jeeva

et al. 2021

Cells

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease 2019 (COVID-19) pandemic. A strong correlation has been demonstrated between worse COVID-19 outcomes, aging, and metabolic syndrome (MetS), which is primarily derived from obesity-induced systemic chronic low-grade inflammation with numerous complications, including type 2 diabetes mellitus (T2DM). The majority of COVID-19 deaths occurs in people over the age of 65. Individuals with MetS are inclined to manifest adverse disease consequences and mortality from COVID-19. In this review, we examine the prevalence and molecular mechanisms underlying enhanced risk of COVID-19 in elderly people and individuals with MetS. Subsequently, we discuss current progresses in treating COVID-19, including the development of new COVID-19 vaccines and antivirals, towards goals to elaborate prophylactic and therapeutic treatment options in this vulnerable population.

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“…Dieser Nachweis der Wirksamkeit wird von allen Arzneimitteln (mit Ausnahme der Homöopathika) als Zulassungsbedingung verlangt und im Detail in der zuständigen Bundesbehörde überprüft.Alle modernen Impfstoffe sind entsprechend in umfangreichen klinischen Prüfungen untersucht, ihre Wirksamkeit ist bewiesen worden [1,8,15,17]. Wie alle Arzneimittel werden sie von der zuständigen Bundesbehörde für den Verkehr zugelassen.…”

Section: Schlüsselwörterunclassified

Zum richtigen Umgang mit Impfstoffen und Tuberkulin

Quast

2001

Monatsschrift Kinderheilkunde

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Immunogenicity trial of inactivated hepatitis A virus vaccine in human volunteers

Cited by 11 publications

References 3 publications

Innate and adaptive immune responses against picornaviruses and their counteractions: An overview

Innate and adaptive immune responses against picornaviruses and their counteractions: An overview

Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome

Zum richtigen Umgang mit Impfstoffen und Tuberkulin

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