2020
DOI: 10.1016/j.ccell.2020.08.019
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Immunogenomic Landscape of Hematological Malignancies

Abstract: We report the immunogenomic landscape of >10,000 hematological malignancies by integrating large-scale genomic, epigenomic, and transcriptomic datasets in this article. During its preparation, we submitted an incorrect version of Figure 1A, in which the numbers of the cases in the Hemap dataset were incorrect (1,288 and 4,293 lymphoma and leukemia samples, respectively; the correct numbers are 1,300 and 4,281). Similarly, in Figure S1A, the number of cell lines in CCLE dataset was incorrect (CHL n = 9 changed … Show more

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Cited by 57 publications
(80 citation statements)
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“…Of note, a close association between the immunological TME and cancer-intrinsic genomic alterations has been recently highlighted 42 and correlated to the response to chemotherapy. In AML, a specific TME-related immunogenomic profile correlates with increased chemoresistance and with response to immunotherapy 43 and a correlation between TP53 mutations and an immunosuppressive TME has been recently established 44,45 .…”
Section: Discussionmentioning
confidence: 99%
“…Of note, a close association between the immunological TME and cancer-intrinsic genomic alterations has been recently highlighted 42 and correlated to the response to chemotherapy. In AML, a specific TME-related immunogenomic profile correlates with increased chemoresistance and with response to immunotherapy 43 and a correlation between TP53 mutations and an immunosuppressive TME has been recently established 44,45 .…”
Section: Discussionmentioning
confidence: 99%
“…Tumors without such genetic evasion strategies are likely immunogenic and must escape from T cell pressure in other ways-their frequent development in extranodal (and immune-privileged) sites is well established (Bruno et al, 2014;Kraan et al, 2013;Shi et al, 2019). These findings also help explain the weak clinical outcomes in single-agent checkpoint blockade trials (Ansell et al, 2019;Lesokhin et al, 2016), even though ABC tumors display inflamed phenotypes and can express checkpoint inhibitors (Dufva et al, 2020). Ultimately, NK-mediated or CAR-T therapies could be better suited for ABC DLBCL.…”
Section: Discussionmentioning
confidence: 99%
“…This includes variability in the presence of cytotoxic lymphocytes, HLA II expression, activating and inhibitory signals produced by tumor cells and antigen presenting cells (APCs), as well as cancer neoantigens. In a broad analysis of patients with hematological malignancies, those with acute leukemias had the lowest cytolytic scores, reflecting lower T and NK cell fractions in the bone marrow ( 18 ). Certain AML subgroups appear to have distinct immunological phenotypes.…”
Section: Immunotherapy In Amlmentioning
confidence: 99%