Immunoglobulin Binding in Cardiomyopathic Hearts

Das, Sunil K.; Callen, Jeffery P.; Dodson, Vernon N.; Cassidy, James T.

doi:10.1161/01.cir.44.4.612

Cited by 41 publications

(10 citation statements)

References 9 publications

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“…Moreover, although most studies have focused on ischemic disorders, deposition of complement has also been found in IDCM. 27 In the present study we found no difference in the degree of complement activation in patients with or without ischemic cardiomyopathy, indicating that a primary ischemic disorder is not a prerequisite for such activation.…”

Section: Aukrust Et Al Complement Activation In Chronic Heart Failurecontrasting

confidence: 54%

Complement Activation in Patients With Congestive Heart Failure

Aukrust¹,

Gullestad²,

Lappegård³

et al. 2001

Circulation

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Background-Increasing evidence implicates innate immunity in the pathogenesis of congestive heart failure (CHF). In the present study, we examined the possible role of complement, an important part of innate immunity, in CHF. Methods and Results-Complement activation was analyzed in systemic and coronary circulation in 39 patients with CHF and 20 healthy control subjects. In a double-blind, placebo-controlled study, we have recently reported that high-dose intravenous immunoglobulin (IVIG) improves left ventricular ejection fraction (LVEF) in these patients. To examine if this improvement was related to IVIG-induced effects on complement, we also examined complement activation during induction (first week) and maintenance therapy (6 months) with IVIG or placebo. Our main findings were: (1) We found enhanced systemic complement activation involving classic, alternative, as well as terminal pathway in patients with CHF compared with healthy control subjects.

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Section: Aukrust Et Al Complement Activation In Chronic Heart Failurecontrasting

confidence: 54%

Complement Activation in Patients With Congestive Heart Failure

Aukrust¹,

Gullestad²,

Lappegård³

et al. 2001

Circulation

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“…The high percentage of myocardium bound immunoglobulins are in agreement with the findings reported by Das et al (1971). These authors demonstrated bound y-globulin in the explanted hearts of patients with congestive cardiomyopathy who had undergone cardiac transplantation.…”

Section: Viral Heart Diseasesupporting

confidence: 91%

Immunological results in myocardial diseases

Bolte¹,

Schultheiss²

1978

Postgraduate Medical Journal

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Summary Immunological studies have shown new diagnostically important changes in alcoholic and viral myocarditis, as well as in congestive cardiomyopathy. Increased heart size correlated with the degree of congestive heart failure, as well as with negative immunofluorescence and an increased IgA concentration in the serum. These findings may serve as a diagnostic aid in patients with myocardial disease due to alcohol abuse. Viral heart disease is characterized by a variety of symptoms and nuclear antibodies (IgM) can be of help in the differential diagnosis. Heart muscle tissue of patients with congestive cardiomyopathy preferentially binds IgG and IgA. In addition to the other changes these findings are of diagnostic importance. It seems likely that results similar to those obtained for humoral antibodies in congestive cardiomyopathy will apply in the correlation of the haemodynamic status of the patients. The pathophysiological implication of these findings is not clear at present, but the evolution of congestive cardiomyopathy appears to be associated with binding of immunoglobulin to the myocardium, as well as with humoral antiheart antibodies.

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“…These findings confirm earlier work in our department13 and contrast with the results of other workers2 14 whose studies were not performed blind. We believe that binding of immunoglobulin is not specific to cardiomyopathy'5 and certainly cannot be incriminated as the primary site of damage, as suggested by Sanders and Ritts.14 Das et al 16 postulated that anti-heart antibodies are not present in the serum because they are bound by antigen in the heart: the findings of the present study and former workl3 do not support this view.…”

Section: Discussioncontrasting

confidence: 55%

Humoral immunity in cardiomyopathy.

Lowry¹,

Thompson²,

Littler³

1983

Heart

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SUMMARY Sera from patients with heart disease were examined by single sandwich indirect immunofluorescence for the presence of antibodies to human heart muscle. Endocardial biopsy specimens were also examined by direct inmunofluorescence for deposition of antibodies in vivo. No consistent or specific abnormality was found in the biopsy specimens or sera of patients with congestive cardiomyopathy. The presence of anti-heart antibodies in cardiac disease appears to reflect damage to cardiac muscle whatever the cause. Immunofluorescence is an insensitive test for anti-heart antibodies.It has been suggested that cardiac damage in congestive cardiomyopathy may be mediated by an autoimmine mechanism.I The role of humoral abnormalities, in particular type II hypersensitivity, has received considerable attention,2-4 but the results and their interpretation vary widely. Previous findings in our department (using baboon heart as substrate) suggested that the role of humoral autoimmunity as a primary cause of congestive cardiomyopathy is not proven5; we undertook a further study to confirm or refute the findings.Our aims were (a) to detect serum autoantibodies to human heart muscle, (b) to detect evidence of in vivo antibody fixation by cardiac antigens, and (c) to demonstrate immune complex deposition in and around myocardial vessels. Patients and methods SEROLOGICAL STUDYSera of 95 patients were examined for the presence of antiheart antibodies. Forty three had cardiomyopathy according to the classification of Goodwin and Oakley6: 28 had congestive cardiomyopathy diagnosed both clinically and by cardiac catheterisation and endomyocardial biopsy, with one exception in which the diagnosis was confirmed at necropsy and 15 had hypertrophic cardiomyopathy, in all but one of whom the diagnosis was confirmed at catheterisation. Nine of the 15 patients in the latter group had a left ventricular outflow tract obstruction detected at catheter-

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Immunoglobulin Binding in Cardiomyopathic Hearts

Cited by 41 publications

References 9 publications

Complement Activation in Patients With Congestive Heart Failure

Complement Activation in Patients With Congestive Heart Failure

Immunological results in myocardial diseases

Humoral immunity in cardiomyopathy.

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