Immunoglobulin Crystal-Storing Histiocytosis in a Pleural Effusion from a Woman with Iga EEMultiple Myeloma

Bone marrow imprints of crystal‐storing histiocytosis

“…They may stain faintly blue‐gray, as in our case, or stain dark blue or brilliant red with various Romanowsky type stains. They are described as cyanophilic with the Papanicolaou stain, but may be difficult to identify since they stain similar to the cytoplasm of the histiocytes . The exact pathogenesis of CSH is incompletely understood.…”

“…They may not stain at all, and be identified as “negatively‐staining” crystals against the proteinaceous smear background or against the cytoplasm or nuclei of the histiocytes . They may stain faintly blue‐gray, as in our case, or stain dark blue or brilliant red with various Romanowsky type stains. They are described as cyanophilic with the Papanicolaou stain, but may be difficult to identify since they stain similar to the cytoplasm of the histiocytes .…”

Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration

“…The histiocytes are consistently positive for CD68. 1,3,8,20,21 CD43 and lysozyme have also been reported to be positive, and S100 protein, CD20, CD3, keratin (AE1/AE3), desmin, and smooth muscle actin negative. 3 The crystals have shown some heterogeneity in their immunohistochemical profile.…”

“…Its cytologic features are not well described. Although isolated case reports have been published illustrating its diagnosis by cytologic examination of pleural fluid, 1 and in a fine-needle aspirate of the parotid gland, 2 to our knowledge this represents the first published report of its diagnosis in a fine-needle aspiration biopsy of the lung. In our case, the fine-needle aspiration biopsy interpretation led to the detection of a monoclonal gammopathy that was clinically unsuspected before the biopsy procedure.…”

Benign Tumors and Tumor-like Lesions of the Lung

“…Regardless of the material accumulated, the basic histopathologic process is similar and includes a histiocytic proliferation. [130][131][132][133][134][135][136][137][138][139][140][141][142][143][144][145][146] …”