Immunoglobulin G4-related spinal pachymeningitis

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is rare disease entity and has recently been recognized as an inflammatory disorder with the tendency to affect multiple organs. Pachymeningitis of spine caused by IgG4-related disease is extremely rare. Neck pain and spinal cord compression symptoms consist of usual presentation of IgG4-related spinal pachymeningitis; however, polyarthritis is an unusual presentation of this disease, and it was reported in only one case that mimicked psoriatic arthritis. In this report, we describe a case of IgG4-related spinal pachymeningitis in a middle-age male who presented initially with neck pain and rheumatoid arthritis-like symptoms and later on developed both right upper and lower limb weakness. He was found to had pachymeningeal thickening on a cervical magnetic resonance image (MRI) and elevated serum IgG4 levels. He was treated with glucocorticoids and rituximab, which led to a significantly positive radiological response.

Differential diagnosis of IgG4-related pancreatitis and pancreatic cancer by MRI features and its correlation with serum IgG4 level

“…Pancreatitis and PC are diseases that occur in the pancreas of the human body, but their nature and degree of harm are different. Clinically, many patients with PC experience early symptoms and are mistaken for pancreatitis and miss the best time for treatment (20). In addition, pancreatitis is divided into acute and chronic pancreatitis, acute pancreatitis will easily develop into chronic pancrea-titis, and inflammation for a long time is easy to deteriorate into PC.…”

Spectre de manifestations de la maladie liée à l’IgG4 : une revue de la littérature

“…La recherche dans les bases de données mentionnées s'est faite par la combinaison ou l'utilisation isolée de ces descripteurs. Hypophysite liée aux DR-IgG4 Alrashdi, 2020;Al-Mujaini et al, 2018;Bong et al, 2021;Boban, Ardal e Thurnher, 2018;Gersey et al, 2021;Ota et al ,2020;Levraut et al, 2019.…”

Espectro de manifestaciones de la enfermedad relacionada con IgG4: una revisión de la literatura

“…Paquimeningitis espinal por DR-IgG4 Paquimeningitis hipertrófica con higroma subdural poliquístico y hematoma en DR-IgG4 Hipofisitis relacionada con DR-IgG4 Alrashdi, 2020;Al-Mujaini et al, 2018;Bong et al, 2021;Boban, Ardal y Thurnher, 2018;Gersey et al, 2021;Ota et al, 2020;Levraut et al, 2019.…”