Immunoglobulin levels in rheumatoid arthritis: Comparison with rheumatoid factor titers, clinical stage and disease duration

Altered immunoglobulin metabolism in systemic lupus erythematosus and rheumatoid arthritis

“…Elevations in serum IgG levels, however, are not uniform and many values fall within the normal range. Elevation of serum IgM levels even in patients with high titers of rheumatoid factor were found to be inconstant (5).…”

“…Alterations in the type and quantity of serum immunoglobulins in rheumatic diseases have been well appreciated (1)(2)(3)(4)(5)(6). The participation of these globulins in the formation of immune complexes has given them a posReceived for publication 28 July 1969. sible pathogenetic role in diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) (1,2).…”

“…Gammaglobulin serum concentrations appear to have little diagnostic or prognostic significance in any single patient and do not differ significantly in these two diseases. Studies in patients with SLE (3) and RA (4)(5)(6) suggest that there is a significant mean increase of serum IgG levels in both these disorders. Elevations in serum IgG levels, however, are not uniform and many values fall within the normal range.…”

Reference distributions for immunoglobulins A, G, and M: A comparison of a large cohort to the world's literature

“…Thirty-two studies reported only an arithmetic mean and insufficient data to estimate a reliable central estimate (13,18,(21)(22)(23)25,27,29,33,37,39,40,44,45,49,54,55,57,58,62,63,65,67,70,80,86,87,92,93,108,115,117). Twenty-two studies did not state a reference material and/or an assay method and were also excluded (11,12,14 1B). Less than a third of these papers stratified their results by gender.…”

Renal involvement in rheumatoid arthritis: analysis of renal biopsy specimens from 100 patients

“…18 Mesangial proliferative GN was considered to be a proper renal lesion in RA in some reports, 2,19,20 but the frequency of mesangial proliferative GN in RA is not higher than that in non-RA patients. The combination of IgA nephropathy and RA has been a particular concern owing to common pathogenetic bases such as HLA-DR4, 21,22 increased serum levels IgA, 23 and IgA-rheumatoid factor. Nakano et al 24 failed to show any correlation between IgA nephropathy in RA and IgA-rheumatoid factor, and explained the difference in the frequency of IgA nephropathy in Japanese RA cases compared with frequencies reported by others workers (7.3% by Helin et al 11 ; 5% by Korpela et al 25 ) as being related to population bias.…”